The mechanism of cell death in response to cytoplasmic DNA, and its role in tumour suppression

细胞质 DNA 导致细胞死亡的机制及其在肿瘤抑制中的作用

• 批准号: nhmrc : 1010887
• 负责人: A/Pr Katryn Stacey
• 金额: $ 34.53万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanism-cell-death-tumour-suppression/109537
• 关键词: mechanism; cell; death; response; cytoplasmic

DNA in mammalian cells is in a structure known as the nucleus. Retroviruses such as HIV generate DNA outside the nucleus in the cytoplasm, and detection of DNA in the cytoplasm can lead to cell death, as a defence. All cells carry the remnants of ancient retroviruses in their nuclear DNA. These are normally inactive but may contribute to cancer when activated. This project investigates how normal cells die with cytoplasmic DNA, and whether a defect in this process promotes development of cancer.

哺乳动物细胞中的 DNA 位于称为细胞核的结构中。 HIV等逆转录病毒在细胞核外的细胞质中产生DNA，作为一种防御，检测到细胞质中的DNA会导致细胞死亡。所有细胞的核 DNA 中都携带着古代逆转录病毒的残余物。这些通常不活跃，但激活后可能会导致癌症。该项目研究正常细胞如何随细胞质 DNA 一起死亡，以及该过程中的缺陷是否会促进癌症的发展。