TLR9 And The Response To Foreign DNA

TLR9 和对外来 DNA 的反应

• 批准号: nhmrc : 301211
• 负责人: A/Pr Katryn Stacey
• 金额: $ 31.06万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tlr9-response-foreign-dna/81981
• 关键词: TLR9; Response; Foreign; DNA

This project is based upon the observation that the mammalian immune system can distinguish between its own genetic material (DNA) and the DNA of infectious agents such as bacteria. This has implications for understanding how the immune system copes with infection, and also for design of new therapies and vaccines. Our central aim is to define how the recognition system for foreign DNA works. The cells that respond most vigorously to foreign DNA are large white blood cells called macrophages. We are investigating how a key protein that is required for these responses functions and what genes it turns on. The type of immune responses initiated by foreign DNA may be useful in treatment of allergies and cancer, and for improving vaccinations.

该项目基于这样的观察：哺乳动物免疫系统可以区分其自身的遗传物质 (DNA) 和细菌等传染源的 DNA。这对于了解免疫系统如何应对感染以及新疗法和疫苗的设计具有重要意义。我们的中心目标是定义外来 D​​NA 识别系统的工作原理。对外源 DNA 反应最强烈的细胞是称为巨噬细胞的大型白细胞。我们正在研究这些反应所需的关键蛋白质如何发挥作用以及它打开哪些基因。由外来 DNA 引发的免疫反应类型可能有助于治疗过敏和癌症，以及改善疫苗接种。