Whole Body Vibration Training for Healthy Body Composition in Young Adults

描述（由申请人提供）：年轻人（18-24岁）特别容易出现身体组成的不健康变化（平均体重增加30磅），使他们容易患上与肥胖有关的疾病。该研究旨在验证积极参与全身振动（WBV）训练将导致抑制脂肪积累，维持瘦肌肉质量和降低与肥胖相关的风险因素水平的新假设。WBV是一种独特的方法，通过被动应用高频、低幅度的机械信号来刺激肌肉骨骼系统。根据我们的初步数据和已发表的研究结果，我们假设，在6个月结束时，与对照组相比，接受20分钟每周3天的WBV训练的年轻人不会体重增加，反而会保持瘦肌肉量。这一假设是基于我们强有力的初步研究，在这些研究中，我们已经表明，反复接触WBV可以减少成年大鼠与年龄相关的脂肪量增加，同时保持瘦肌肉量。在老年人中的其他初步发现表明，在保持瘦体重的同时，WBV干预在减少体重、脂肪质量和体脂百分比方面是有效的。在本研究中，将进行为期6个月的随机对照试验，分为两组：1)全身振动组和2)注意控制放松组，通过以下目的来验证这一假设：评估实施全身振动（WBV）运动训练计划作为预防18-24岁无运动的年轻人体重增加和脂肪量增加的治疗效果和可行性。主要结局指标包括：通过双能x线吸收仪（DXA）测量的总体重、体脂百分比、脂肪量、内脏脂肪组织和无脂肪量。这项拟议的研究具有潜在的创新性，因为它利用了一种新的治疗技术- WBV，通过被动应用高频，低振幅机械信号刺激肌肉骨骼系统来改善身体成分。该研究的成功完成将确立WBV训练作为一种安全可行的方案，具有高度的依从性和可接受性，可预防年轻人体重增加。在6个月结束时，接受20分钟WBV 3d/周的年轻人将保持他们的体重，并将拥有更健康的身体组成（瘦脂肪质量）。该申请旨在满足美国国立卫生研究院的战略目标，即鼓励探索性/发展性临床研究，这将加速有效干预措施的发展，以预防或治疗成人和/或儿童的超重和/或肥胖，PA-09-124肥胖症探索性/发展性临床研究资助（R21）。这种新的、实质上不同的方法有望克服招募、留住和激励年轻人保持体重稳定的困难，通常与其他长期减肥计划有关，从而形成一种有效的预防体重增加的方法。！

DESCRIPTION (provided by applicant): Young adults (18-24 years) are particularly prone to unhealthy changes in body composition (average weight gain 30 pounds) that predispose them to development of obesity-related diseases. The proposed research is designed to test the novel hypothesis that active participation in whole-body vibration (WBV) training will result in suppression of accumulation of fat, maintenance of lean muscle mass and reduced levels of risk factors as- sociated with obesity. WBV involves a unique method of stimulating the musculoskeletal system through pas- sive application of high frequency, low amplitude mechanical signals. Based upon our preliminary data and published findings, it is hypothesized that, at the end of 6-months, young adults receiving a 20-minute of WBV 3 d/wk, will not experience weight gain but will instead maintain lean muscle mass compared to those assigned to the control group. This hypothesis is based on our strong preliminary studies, in which we have shown that repeated exposure to WBV reduced age-related increases in fat mass in mature rats while maintaining lean muscle mass. Additional preliminary findings in older adults suggest a WBV intervention to be effective in re- ducing body mass, fat mass and percent body fat while maintaining lean mass. In the proposed study, a 6- month randomized controlled trial will be carried out with two groups: 1) WBV and 2) attention control relaxa- tion group, to test th hypothesis by through the following Aim: To evaluate the therapeutic benefits and feasi- bility of implementing a whole-body vibration (WBV) exercise training program as a method of preventing weight gain and increases in fat mass in physically inactive young adults (18-24 yrs.). Primary outcome meas- ures include: Total body weight, % body fat, fat mass, visceral adipose tissue, and fat free mass, measured by dual energy X-ray absorptiometry (DXA). The proposed study is potentially innovative because it capitalizes on a new therapeutic technique - WBV to improve body composition by stimulating the musculoskeletal system through the passive application of high frequency, low amplitude mechanical signals. Successful completion of the proposed research would establish WBV training as a safe and feasible program with high compliance and acceptability for preventing weight gain in young adults. At the end of 6-months, young adults receiving a 20- min. of WBV 3d/wk will have maintained their body weight and will have a healthier body composition (lean-fat mass). This application addresses the NIH strategic goal to encourage exploratory/developmental clinical re- search that will accelerate development of effective interventions for prevention or treatment of overweight and/or obesity in adults and/or children and, PA-09-124 Exploratory/Developmental Clinical Research Grants in Obesity (R21). This new and substantively different approach is expected to overcome difficulties of recruiting, retaining, and motivating young adults to remain weight stable, often associated with other long term weight programs, thereby resulting in an efficacious approach to weight gain prevention. !