Building Implementation Science Capacity in HIV at Makerere University

项目摘要 尽管乌干达已在艾滋病毒项目上投入了大量资源， 实现80%的普及目标。虽然扭转全球局势的潜力 流行病从未如此严重，成功将需要基于证据的干预措施， 成为日常护理的一部分。我们认为，当今艾滋病毒/艾滋病方面最紧迫的问题是 如何实施和传播经证实的公共卫生干预措施。参与护理是 病人和公共卫生系统之间的接口。研究如何参与 患者需要以最佳方式提供护理。 自1980年代后期以来，乌干达开展了一些大型合作， 艾滋病、结核病和疟疾的研究，其中许多都非常成功。 然而，对执行科学研究的重视不够， 应对艾滋病疫情。预防艾滋病毒和提供最佳艾滋病毒护理的工具 和治疗是可用的，并得到证明，成功的公共卫生现在取决于有效的 和有效的服务-通过患者的参与-在整个护理级联中。我们建议 使用实施科学框架，使多学科的观点承担 及时识别艾滋病毒感染者，加速与护理的联系，适当启动 抗逆转录病毒疗法和继续护理艾滋病毒感染者。医疗 艾滋病毒感染者的参与和治疗依从性将使抗逆转录病毒药物 药物，以达到最佳的公共卫生影响。 马凯雷雷大学是东非排名最高的大学， 二十年来，学校一直是应对艾滋病毒/艾滋病的中心。Makerere 大学科学学院（MakCHS）与UCSF合作了三十多年 一系列科学研究，目前正在合作进行一些NIH资助的 研究和培训赠款。我们计划利用这一基础， 实施科学的平台，以研究护理的级联。 这项规划补助金的目标是开发一个全面的应用程序， 实施科学研究（ISR）的研究培训计划，重点是参与 在Makchs照顾。培训计划将建立在现有的艾滋病毒研究和护理基础上 影响公共卫生的项目。这项规划补助金的具体目标是：（1） 正式成立一个规划委员会，以制定和提交一份完整的申请，（2）巩固正在进行的 MakCHS和UCSF之间的合作研究活动，并形成新的联系，（3） 进行系统的调查，以评估现有的研究和训练能力，在ISR MakCHS，（4）确定可招募参加ISR培训的潜在受训人员库，以及（5） 根据确定的需求制定培训计划。这些目标将通过一系列 MakCHS，UCSF，乌干达卫生部和其他研究人员之间的规划演习 合作团体。

Project Summary Although significant resources have been invested in HIV programs, Uganda is still far from the universal access target of 80%. While the potential to turn the tide on the global epidemic has never been greater, success will require that evidence-based interventions become part of routine care. We believe that the most urgent question in HIV/AIDS today is how to implement and disseminate proven public health interventions. Engagement in care is the interface between patients and the public health system. Research on how to engage patients is required to optimally deliver care. Since the late 1980s, a number of large collaborations were developed in Uganda for research in HIV, tuberculosis, and malaria, and many of these have been highly successful. However, there has been insufficient focus on implementation science research to strengthen the response to the HIV epidemic. The tools to prevent HIV and to optimally provide HIV care and treatment are available and proven, and successful public health now depends on efficient and effective delivery- through patient engagement- across the cascade of care. We propose to use the implementation science framework to bring multi-disciplinary perspectives to bear on timely identification of HIV-infected individuals, accelerated linkage to care, appropriate initiation of antiretroviral therapy, and retention of HIV-infected patients in care. Medical care engagement and treatment adherence among HIV-infected individuals will allow antiretroviral medications to reach their optimal public health impact. Makerere University is the highest ranked university in East Africa and the medical school has been at the center of the response to HIV/AIDS for two decades. Makerere University College of Sciences (MakCHS) has collaborated with UCSF for over three decades on a range of scientific studies and is currently collaborating on a number of NIH funded research and training grants. We plan to leverage this foundation to create a world-class platform for implementation science to study the cascade of care. The goal of this planning grant is to develop an application for a comprehensive research training program in Implementation Science Research (ISR) focused on engagement in care at MakCHS. The training program will build on established HIV research and care programs to impact upon public health. The specific objectives of this planning grant are to: (1) formalize a planning committee to develop and submit a full application, (2) solidify ongoing collaborative research activities between MakCHS and UCSF and form new linkages, (3) conduct a systematic survey to assess existing research and training capacity in ISR at MakCHS, (4) define a pool of potential trainees that could be recruited for ISR training, and (5) develop a training plan tailored to identified needs. These objectives will be met through a series of planning exercises between investigators at MakCHS, UCSF, the Uganda MOH and other collaborating groups.