Building Implementation Science Capacity at Makerere University to Strengthen the Response to the HIV/AIDS Epidemic in Uganda

项目摘要 虽然乌干达接近实现90-90-90的目标，但超过27%的乌干达艾滋病毒携带者仍然患有 可检测到的病毒载量和极大地促进新感染的可能性。乌干达面临着挑战， 艾滋病毒护理和预防，特别是针对男子、青年和继续在地理上流动的亚群 达不到病毒抑制目标，使他们面临艾滋病毒并发症、死亡和后续艾滋病毒的风险 变速箱。随着艾滋病毒人口的老龄化，共病的负担越来越大，如非 预防和控制非传染性疾病以及整合非传染性疾病--艾滋病毒护理对于改善艾滋病毒的结果至关重要。 需要实施科学(IMS)的研究能力来优化有效的公共健康影响 对符合条件的人群进行检测和治疗和暴露前预防等干预措施。 建立在Makerere大学(MU)及其附属艾滋病毒项目和 加州大学旧金山分校(UCSF)，我们已经建立了一个先驱的IMS研究培训 密歇根州立大学的计划侧重于加强艾滋病毒护理的级联。我们为IMS奠定了坚实的基础 通过培训，将免疫管理系统纳入MU的一个研究领域，并影响艾滋病毒的做法。我们建议 继续该计划，并在下一阶段专注于创造IMS研究的持续增长 年，密歇根大学的环境和IMS应用于更大规模的艾滋病毒研究和服务提供 乌干达。我们的研究培训计划续签申请的具体目标是：1)加强 科学领导能力和实施科学研究所需的专业知识，重点放在 MU博士培训；2)扩大MU IMS实施科学研究的培训广度；3) 通过利用乌干达的额外可用资源，优化培训资源的利用 (包括由NIH、欧洲和发展中国家临床试验伙伴关系(EDCTP)资助的项目， 总统艾滋病紧急救援计划(PEPFAR)等；4)加强实习生对 通过定期提供与艾滋病毒预防、护理和治疗服务有关的循证决策 与政策制定者和艾滋病毒方案实施者的互动；以及5)支持免疫管理系统受训人员的融合 进入乌干达的学术、研究、政策和艾滋病毒执行机构：a)追求独立的科学 (B)加强在艾滋病毒服务提供中使用免疫管理系统。拟议的IMS培训方案将 在我们与加州大学旧金山分校教职员工关系的基础上，提供基于每月 正在进行的工作会议(通过在线平台虚拟举行)。在我们的五年计划中，我们预计 培训乌干达学员如下：4名博士生和10名硕士生 MU，40名研究生文凭，实施科学研究和质量改进 加州大学旧金山分校IMS项目在线证书的6名考生。 1|页码

Project Summary While Uganda is close to achieving the 90-90-90 targets, more than 27% of Ugandans with HIV remain with a detectable viral load and the potential to substantially contribute to new infections. Uganda faces challenges with HIV care and prevention, in particular for men, youth and geographically mobile subpopulations that continue to fall short of viral suppression targets, putting them at risk for HIV complications, mortality, and onward HIV transmission. With the aging HIV population there is increasing burden of comorbidities such as non- communicable diseases (NCDs), and integration of NCD-HIV care is paramount to improve HIV outcomes. Implementation science (ImS) research capacity is needed to optimize the public health impact of efficacious interventions such as test-and-treat and pre-exposure prophylaxis (PrEP) for eligible populations. Building on existing partnerships between Makerere University (MU) and its affiliated HIV programs and the University of California, San Francisco (UCSF), we have established a pioneer ImS Research Training Program at MU focused on enhancing the cascade of HIV care. We have built a strong foundation for ImS in Uganda through training, integrating ImS as a field of study at MU and influencing HIV practices. We propose to continue the Program and focus the next period on creation of sustained growth of ImS research environment at MU and the application of ImS to bear on HIV research and service delivery on a larger scale in Uganda. The specific objectives of our research training program renewal application are to: 1) strengthen the scientific leadership and expertise needed for implementation science research by having increased focus on PHD training at MU; 2) expand the breadth of training in ImS implementation science research at MU; 3) optimize utilization of resources for training by leveraging the additional available resources in Uganda (including projects funded by the NIH, European and Developing Country Clinical Trials Partnership (EDCTP), President’s Emergency Plan for AIDS Relief (PEPFAR), and others; 4) strengthen trainee contributions to evidence-based decision-making related to HIV prevention, care and treatment services through regular interactions with policy makers and HIV program implementers; and 5) support the integration of ImS trainees into Ugandan academic, research, policy and HIV implementing institutions to: a) pursue independent scientific careers in ImS and b) strengthen use of ImS in HIV service delivery. The proposed ImS training program will build on our relationships with UCSF faculty to provide a longitudinal mentorship program based on monthly works-in-progress meetings (held virtually via online platforms). During our five-year program, we anticipate training Ugandan trainees as follows: 4 candidates in PhD and 10 candidates in master’s degree programs at MU, 40 candidates in a Post Graduate Diploma in Implementation science research and quality Improvement and 6 candidates in the UCSF Online Certificate in ImS program. 1|Page