Building Implementation Science Capacity in HIV at Makerere University

麦克雷雷大学艾滋病毒实施科学能力建设

• 批准号: 8710370
• 负责人: MOSES Robert KAMYA
• 金额: $ 3.02万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8710370
• 关键词: AIDS/HIV problem; Africa; Anti-Retroviral Agents; Caring; Collaborations; Epidemic; Evidence based intervention; Exercise; Foundations; Funding; Goals; Grant; HIV; Health system; Individual; Intervention; Malaria; Medical; Patients; Pharmaceutical Preparations; Public Health; Recruitment Activity; Research; Research Activity; Research Personnel; Research Training; Resources; Science; Series; Surveys; Training; Training Programs; Tuberculosis; Uganda; United States National Institutes of Health; Universities; Ursidae Family; antiretroviral therapy; college; implementation science; medical schools; meetings; prevent; programs; response; routine care; success; tool; treatment adherence

DESCRIPTION (provided by applicant): Although significant resources have been invested in HIV programs, Uganda is still far from the universal access target of 80%. While the potential to turn the tide on the global epidemic has never been greater, success will require that evidence-based interventions become part of routine care. We believe that the most urgent question in HIV/AIDS today is how to implement and disseminate proven public health interventions. Engagement in care is the interface between patients and the public health system. Research on how to engage patients is required to optimally deliver care. Since the late 1980s, a number of large collaborations were developed in Uganda for research in HIV, tuberculosis, and malaria, and many of these have been highly successful. However, there has been insufficient focus on implementation science research to strengthen the response to the HIV epidemic. The tools to prevent HIV and to optimally provide HIV care and treatment are available and proven, and successful public health now depends on efficient and effective delivery- through patient engagement- across the cascade of care. We propose to use the implementation science framework to bring multi-disciplinary perspectives to bear on timely identification of HIV-infected individuals, accelerated linkage to care, appropriate initiation of antiretroviral therapy, and retention of HIV-infected patients in care. Medical care engagement and treatment adherence among HIV-infected individuals will allow antiretroviral medications to reach their optimal public health impact. Makerere University is the highest ranked university in East Africa and the medical school has been at the center of the response to HIV/AIDS for two decades. Makerere University College of Sciences (MakCHS) has collaborated with UCSF for over three decades on a range of scientific studies and is currently collaborating on a number of NIH funded research and training grants. We plan to leverage this foundation to create a world-class platform for implementation science to study the cascade of care. The goal of this planning grant is to develop an application for a comprehensive research training program in Implementation Science Research (ISR) focused on engagement in care at MakCHS. The training program will build on established HIV research and care programs to impact upon public health. The specific objectives of this planning grant are to: (1) formalize a planning committee to develop and submit a full application, (2) solidify ongoing collaborative research activities between MakCHS and UCSF and form new linkages, (3) conduct a systematic survey to assess existing research and training capacity in ISR at MakCHS, (4) define a pool of potential trainees that could be recruited for ISR training, and (5) develop a training plan tailord to identified needs. These objectives will be met through a series of planning exercises between investigators at MakCHS, UCSF, the Uganda MOH and other collaborating groups.

描述（由申请人提供）：尽管乌干达已在艾滋病毒方案中投入了大量资源，但距离80%的普及目标仍有很大差距。虽然扭转这一全球流行病趋势的潜力从未如此之大，但要取得成功，就需要将循证干预措施纳入日常护理。我们认为，今天在艾滋病毒/艾滋病方面最紧迫的问题是如何执行和传播已证明有效的公共卫生干预措施。参与护理是病人和公共卫生系统之间的接口。需要研究如何让患者参与进来，以最佳方式提供护理。 自20世纪80年代末以来，乌干达在艾滋病毒、结核病和疟疾研究方面开展了许多大型合作，其中许多都非常成功。然而，对加强艾滋病毒流行对策的执行科学研究重视不够。预防艾滋病毒和提供最佳艾滋病毒护理和治疗的工具已经存在并得到证实，成功的公共卫生现在取决于通过患者参与在整个护理级联中高效和有效地提供服务。我们建议使用实施科学框架，将多学科观点用于及时识别艾滋病毒感染者， 艾滋病毒/艾滋病的预防和治疗，包括对艾滋病毒感染者的治疗、加速与护理的联系、适当启动抗逆转录病毒疗法以及继续对艾滋病毒感染者进行护理。艾滋病毒感染者的医疗保健参与和治疗坚持将使抗逆转录病毒药物发挥最佳的公共卫生影响。 马凯雷雷大学是东非排名最高的大学，医学院二十年来一直是应对艾滋病毒/艾滋病的中心。Makerere University College of Sciences（MakCHS）与UCSF合作了三十多年，进行了一系列科学研究，目前正在合作一些NIH资助的研究和培训赠款。我们计划利用这个基础来创建一个世界级的实施科学平台，以研究护理的级联。 该计划补助金的目标是开发一个应用程序，用于实施科学研究（ISR）的综合研究培训计划，重点关注MakCHS的护理参与。培训计划将建立在既定的艾滋病毒研究和护理计划的基础上，以影响公共卫生。这项规划补助金的具体目标是：（1）正式成立一个规划委员会，以制定和提交一份完整的申请，（2）巩固MakCHS和UCSF之间正在进行的合作研究活动，并形成新的联系，（3）进行系统调查，以评估MakCHS ISR的现有研究和培训能力，（4）确定一个可以招募ISR培训的潜在学员库，及（5）制订切合所确定需要的培训计划。这些目标将通过MakCHS、加州大学旧金山分校、乌干达卫生部和其他合作小组的调查人员之间的一系列规划活动来实现。