Building Implementation Science Capacity at Makerere University to Strengthen the Response to the HIV/AIDS Epidemic in Uganda

项目摘要 虽然乌干达接近实现90-90-90的目标，但超过27%的乌干达艾滋病毒感染者仍然处于艾滋病病毒感染状态。 可检测的病毒载量和潜在的实质上有助于新的感染。乌干达面临挑战， 艾滋病毒的护理和预防，特别是对男子、青年和在地域上移动的亚群的护理和预防，这些亚群继续 达不到病毒抑制目标，使他们面临艾滋病毒并发症、死亡率和进一步感染艾滋病毒的风险 传输随着艾滋病毒感染人群的老龄化，合并症的负担越来越大，如非- 艾滋病毒/艾滋病防治是防治非传染性疾病的一项重要措施，而非传染性疾病和艾滋病毒护理的一体化对于改善艾滋病毒防治成果至关重要。 需要实施科学（ImS）研究能力，以优化有效的公共卫生影响。 对符合条件的人群进行检测和治疗以及暴露前预防（PrEP）等干预措施。 在马凯雷雷大学（MU）及其附属艾滋病毒方案与 加州大学旧金山弗朗西斯科（UCSF），我们已经建立了一个先驱ImS研究培训 MU的方案侧重于加强艾滋病毒护理的级联。我们为ImS建立了坚实的基础， 乌干达通过培训，将ImS作为MU的一个研究领域，并影响艾滋病毒的做法。我们提出 继续该计划，并将下一阶段的重点放在创造ImS研究的持续增长上 环境在MU和ImS的应用，以承担艾滋病毒的研究和服务提供在更大的规模， 乌干达我们的研究培训计划更新申请的具体目标是：1）加强 科学研究所需的科学领导和专门知识， 在MU的博士培训; 2）扩大在MU的ImS实施科学研究培训的广度; 3） 通过利用乌干达的额外可用资源，优化培训资源的利用 （包括由NIH、欧洲和发展中国家临床试验伙伴关系（EDCTP）资助的项目， 总统艾滋病紧急救援计划（PEPFAR）等; 4）加强受训人员对以下方面的贡献： * 通过定期的艾滋病毒预防、护理和治疗服务， 与政策制定者和艾滋病毒方案执行者的互动;以及5）支持ImS受训人员的融合 乌干达的学术、研究、政策和艾滋病毒执行机构：a）进行独立的科学研究， B）加强在艾滋病毒服务提供中使用ImS。拟议的ImS培训计划将 建立我们与UCSF教师的关系，提供基于每月的纵向导师计划， 正在进行的工作会议（通过在线平台虚拟举行）。在我们的五年计划中，我们预计 培训乌干达受训人员如下：4名博士候选人和10名硕士学位候选人， MU，40名候选人在实施科学研究和质量改进研究生文凭 和6名候选人在UCSF在线证书ImS程序。 1|页面

Project Summary While Uganda is close to achieving the 90-90-90 targets, more than 27% of Ugandans with HIV remain with a detectable viral load and the potential to substantially contribute to new infections. Uganda faces challenges with HIV care and prevention, in particular for men, youth and geographically mobile subpopulations that continue to fall short of viral suppression targets, putting them at risk for HIV complications, mortality, and onward HIV transmission. With the aging HIV population there is increasing burden of comorbidities such as non- communicable diseases (NCDs), and integration of NCD-HIV care is paramount to improve HIV outcomes. Implementation science (ImS) research capacity is needed to optimize the public health impact of efficacious interventions such as test-and-treat and pre-exposure prophylaxis (PrEP) for eligible populations. Building on existing partnerships between Makerere University (MU) and its affiliated HIV programs and the University of California, San Francisco (UCSF), we have established a pioneer ImS Research Training Program at MU focused on enhancing the cascade of HIV care. We have built a strong foundation for ImS in Uganda through training, integrating ImS as a field of study at MU and influencing HIV practices. We propose to continue the Program and focus the next period on creation of sustained growth of ImS research environment at MU and the application of ImS to bear on HIV research and service delivery on a larger scale in Uganda. The specific objectives of our research training program renewal application are to: 1) strengthen the scientific leadership and expertise needed for implementation science research by having increased focus on PHD training at MU; 2) expand the breadth of training in ImS implementation science research at MU; 3) optimize utilization of resources for training by leveraging the additional available resources in Uganda (including projects funded by the NIH, European and Developing Country Clinical Trials Partnership (EDCTP), President’s Emergency Plan for AIDS Relief (PEPFAR), and others; 4) strengthen trainee contributions to evidence-based decision-making related to HIV prevention, care and treatment services through regular interactions with policy makers and HIV program implementers; and 5) support the integration of ImS trainees into Ugandan academic, research, policy and HIV implementing institutions to: a) pursue independent scientific careers in ImS and b) strengthen use of ImS in HIV service delivery. The proposed ImS training program will build on our relationships with UCSF faculty to provide a longitudinal mentorship program based on monthly works-in-progress meetings (held virtually via online platforms). During our five-year program, we anticipate training Ugandan trainees as follows: 4 candidates in PhD and 10 candidates in master’s degree programs at MU, 40 candidates in a Post Graduate Diploma in Implementation science research and quality Improvement and 6 candidates in the UCSF Online Certificate in ImS program. 1|Page