6th International Workshop on Seizure Prediction

第六届癫痫发作预测国际研讨会

• 批准号: 8597679
• 负责人: BRUCE J GLUCKMAN
• 金额: $ 2.3万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597679
• 关键词: Address; Advertising; Area; Attention; Biological; Brain; Clinical; Collaborations; Communities; Development; Devices; Educational workshop; Electroencephalography; Electrophysiology (science); Engineering; Epilepsy; Equipment; Funding; Generations; Goals; International; Intervention; Lead; Measures; Metric; Modeling; Neocortex; Neurons; Neurosciences; Neurosciences Research; Neurosurgeon; Organism; Participant; Physiological; Research Personnel; Seizures; Site; Societies; Syndrome; System; Time; Travel; base; cost; interdisciplinary approach; meetings; neurophysiology; novel; novel strategies; public health relevance; symposium; theories; therapy development

DESCRIPTION (provided by applicant): The overall objective of this effort is to convene the Sixth International Workshop on Seizure Prediction, a forum that brings together an international interdisciplinary group involving epileptologists, engineers, physicists, mathematicians, neurosurgeons and neuroscientists focused on the development of treatments for epilepsy especially based on closed loop prediction and interventions. While this goal has not changed, the group has recognized that the focus of attention needs to shift away from a biological mechanism-free algorithmic approach to EEG and related electrophysiology recordings, and toward a better understanding of underlying physiological mechanisms as they specifically relate to clinical recordings. At a fundamental level, the goal of seizure prediction is to identif the underlying mechanisms of seizure generation and to engineer systems that will detect those dynamics and provide for intervention. This meeting will focus attention on basic questions at the intersection of engineering, computational and epilepsy neuroscience necessary for predicting and intervening with seizures: how seizures arise in the neocortex, how to identify sites of seizure origination, how seizures spread, and how they terminate. We have identified these topics as key roadblocks to further advances in treatment of pharmacoresistant epilepsy syndromes. Through these questions we will focus attention on bridging clinical and physiological metrics to arrive at new approaches to understand epileptic seizure generation mechanisms across all scales of brain from neuron to organism, and especially close the loop between models of seizure generation and physiological observations.

描述（由申请人提供）：这项工作的总体目标是召开第六届癫痫发作预测国际研讨会，该论坛汇集了一个国际跨学科小组，涉及癫痫学家，工程师，物理学家，数学家，神经外科医生和神经科学家，专注于开发癫痫治疗方法，特别是基于闭环预测和干预。虽然这一目标没有改变，但该小组已经认识到，注意力的焦点需要从EEG和相关电生理记录的无生物机制算法方法转移到更好地理解潜在的生理机制，因为它们与临床记录特别相关。在基本层面上，癫痫发作预测的目标是识别癫痫发作产生的潜在机制，并设计能够检测这些动态并提供干预的系统。本次会议将重点关注预测和干预癫痫发作所需的工程，计算和癫痫神经科学交叉的基本问题：癫痫发作如何在新皮层中出现，如何识别癫痫发作起源的部位，癫痫发作如何传播以及如何终止。我们已经确定这些主题为进一步发展耐药性癫痫综合征治疗的关键障碍。通过这些问题，我们将把注意力集中在桥接临床和生理指标上，以找到新的方法来理解从神经元到生物体的所有大脑尺度的癫痫发作产生机制，特别是闭合癫痫发作产生模型和生理观察之间的循环。