Central mechanisms of color vision

视觉系统已经成为理解的首要模型 神经元的信息处理在视觉中，颜色的次模态 提供了一个特别有吸引力的实验平台：我们知道一个巨大的 关于颜色感知的现象学，可以解释一些 颜色感知方面，定量和高精度，通过良好的- 了解生理过程。由于这一进展，我们可以很快 准确诊断多种不同形式的色盲， 能准确呈现颜色的设备。另一方面，我们对 色觉的神经生理学主要限于视网膜。中央 颜色视觉的机制在很大程度上是未知的，颜色的许多方面 感知不能用视网膜机制来解释。拟议研究 是衡量信号的质量和行为相关性， 调节色觉的视网膜。具体目标有两个：1）单神经元 记录在初级视觉皮层，以确定最有可能 是色觉的基础2)初级视皮层的单神经元记录 研究影响颜色外观的操作如何影响神经元反应。 所提出的实验扩展了我们对色觉的认识， 理解引起感知的神经科学原理， 它的失调。这样一种理解有望提供促进 创伤或神经系统疾病后视觉功能的恢复。

The visual system has emerged as a premier model for understanding information processing by neurons. Within vision, the submodality of color provides a particularly attractive experimental platform: we know a tremendous amount about the phenomenology of color perception and can explain some aspects of color perception, quantitatively and with high precision, by well- understood physiological processes. As a result of this progress, we can quickly and accurately diagnose many distinct forms of color blindness and can build devices that render colors accurately. On the other hand, our understanding of the neurophysiology of color vision is largely restricted to the retina. The central mechanisms of color vision are largely unknown, and many aspects of color perception cannot be explained by retinal mechanisms. The proposed research is to measure the quality and behavioral relevance of the signals beyond the retina that mediate color vision. Two specific aims are planned: 1) Single neuron recording in the primary visual cortex to identify the neurons most likely to underlie color vision. 2) Single neuron recording in the primary visual cortex to study how manipulations that affect color appearance affect neuronal responses. The proposed experiments extend our knowledge of color vision toward an understanding of the principles of neuroscience that give rise to perception and its disorders. Such an understanding promises to provide the means to promote recovery of visual function following trauma or neurological disease.