Inherited genetic variants as prognostic markers for colorectal cancer

遗传性基因变异作为结直肠癌的预后标志物

• 批准号: nhmrc : 1011850
• 负责人: A/Pr Lara Lipton
• 金额: $ 41.61万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inherited-genetic-variants-colorectal-cancer/109619
• 关键词: Inherited; genetic; variants; prognostic; markers

Bowel cancer is a major health burden. Surgical resection of the primary cancer is often possible at diagnosis, yet in many patients the cancer will recur. Together with mutations, inherited genetic variants influence the rate of bowel cancer growth. This study aims to identify inherited variants predictive of cancer recurrence. Improved prediction of recurrence will permit more targeted use of clinical interventions, tailored to the individual patient, ultimately improving patient survival.

肠癌是一个主要的健康负担。原发癌的手术切除通常在诊断时是可能的，但在许多患者中，癌症会复发。遗传性遗传变异与突变一起影响肠癌的生长速度。这项研究的目的是确定预测癌症复发的遗传变异。改进的复发预测将允许更有针对性地使用针对个体患者的临床干预措施，最终提高患者的生存率。