Analysis of gene amplification-loss and methylation associated with progression to metastatic colorectal cancer

与转移性结直肠癌进展相关的基因扩增缺失和甲基化分析

• 批准号: nhmrc : 489418
• 负责人: A/Pr Lara Lipton
• 金额: $ 41.35万
• 依托单位: Ludwig Institute for Cancer Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/analysis-gene-amplification-colorectal-cancer/97029
• 关键词: Analysis; gene; amplification; loss; methylation

Many bowel cancers can be removed by surgery, but in many cases the cancer reoccurs. While chemotherapy can reduce the chance of recurrence, it can produce significant side effects. Currently there are few markers to indicate change of recurrence, therefore deciding who should, or should not receive chemotherapy is difficult to decide. This study will analyse differences in DNA from patients that do and do not relapse, to guide future decisions on patients who will benefit from chemotherapy.

许多肠癌可以通过手术切除，但在许多情况下，癌症会复发。虽然化疗可以减少复发的机会，但它会产生显著的副作用。目前，很少有标志物表明复发的变化，因此很难决定谁应该或不应该接受化疗。这项研究将分析复发和不复发患者的DNA差异，以指导未来对将从化疗中受益的患者的决定。