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中文摘要
翻译
描述(由申请人提供):良性泌尿系统疾病是一个主要的公共卫生问题。不幸的是,没有足够数量的训练有素的跨学科研究人员专注于这些疾病。为了克服这一限制,我们建议发展杜克大学Kure(K12多学科泌尿外科研究)学者计划。该计划将建立在对良性泌尿系统研究的重要机构支持的基础上,并利用现有的培训计划,同时允许我们向一批非常有前途的年轻研究人员提供深入的研究培训,专注于良性泌尿系统疾病。Kure学者将在不少于3名导师/学者的指导下接受针对其个人需求和目标的强化培训经验-一名具有临床疾病相关专业知识,一名具有研究方法专业知识,一名具有生物统计学专业知识。每个团队由一名学者和三名导师组成,将从导师库中分配一名二级导师。二级导师的作用是为学者提供额外的帮助,但也向初级导师提供“独立”的反馈,以确保协调和改进导师的辅导(“教老师”)。一旦集合,这些指导团队将作为一个完整的团队,至少每季度与学者会面一次。每名奖学金获得者还将至少每月与每位导师单独会面。学者将从事由学者设计的研究项目,但在指导团队的监督和指导下进行。这种团队方法旨在为学者提供最大限度地发展和提高他们的研究技能(临床、研究和生物统计学)的机会,这将在研究设计、同行评议的出版物和未来的资助机会方面最大限度地提高学者教育。此外,所有学者都将参加专门为泌尿科研究人员设计的为期一年的教学课程。这门课程在杜克大学已经存在,由Kure学者项目的PI/PD Stephen Freedland博士指导。除了标准的为期一年的课程,学员将有机会进入整个杜克大学的课程,以进一步提高他们的教育需求。事实上,我们预计所有Kure学者都将参与这些额外的培训机会,其中许多人获得了研究生学位(例如临床研究硕士学位)。 Kure学者计划的具体目标是: *招募和培养下一代良性泌尿外科研究人员 *2.培养下一代导师,培养未来良性的泌尿外科研究人员 *3.提升研究导师的整体辅导水平 *4.与全国其他机构分享我们Kure学者计划的成功之处 我们实现这些目标的方法在应用程序中有详细的概述。虽然Kure资助的学者的确切数量每年都会根据学者的可获得性而有所不同,但我们预计,在理想的情况下,我们将有4名Kure资助的学者:2名初级教员(MD或MD/PhD),1名住院医师(MD或MD/PhD),以及1名高级博士后研究员(PhD)。杜克大学Kure项目通过提供一个庞大和多样化的辅导池,建立在机构优势的基础上。事实上,杜克大学是培养下一代良性泌尿科研究领域领导者的理想人选。虽然杜克大学Kure奖学金项目的初始资助期为5年,但我们希望通过成功培训泌尿科研究学者并帮助他们取得未来的学术成功,我们将能够无限期地继续提供Kure资助。
英文摘要
DESCRIPTION (provided by applicant): Benign urological diseases are a major public health concern. Unfortunately, there are insufficient numbers of well-trained cross-disciplinary researchers focused on these conditions. To overcome this limitation, we propose the development of the Duke KURe (K12 Multidisciplinary Urologic Research) Scholars Program. This program would build upon significant institutional support for benign urological research as well as leverage a pre-existing training program while allowing us to provide in-depth research training to a select group of very promising young investigators focused on benign urological diseases. KURe Scholars will undergo an intensive training experience tailored to their individual needs and goals under the guidance of no less than 3 mentors/scholar - one with clinical disease-related expertise, one with research approach-based expertise, and one with biostatistical expertise. Each team of one scholar and three mentors will be assigned a secondary mentor from the mentor pool. The role of the secondary mentor is to provide additional assistance to the scholar, but also to provide "independent" feedback to the primary mentors to ensure coordination and improve the mentoring of the mentors ("teaching the teachers"). Once assembled, these mentoring teams will meet with the scholar no less than quarterly as an entire team. Each scholar will also meet individually with each mentor at least monthly. Scholars will work on research projects designed by the scholar, but under the supervision and guidance of the mentoring team. This team approach is designed to maximize opportunities for the scholars to develop and improve their research skills (clinical, research, and biostatistical), which will maximize scholar education in terms of research design, peer-reviewed publications and future grant opportunities. In addition, all scholars will participate ina year-long course of didactic classes designed specifically for urological researchers. This course already exists at Duke, under the guidance of Dr. Stephen Freedland, PI/PD of the KURe Scholars Program. Beyond the standard year-long course, trainees will have access to classes throughout Duke University to further enhance their educational needs. Indeed, we anticipate all KURe scholars will partake of these extra training opportunities, with many obtaining graduate degrees (e.g. Masters of Clinical Research). The specific goals of the KURe Scholars Program are to: * To recruit and train the next generation of benign urological researchers * 2. Train the next generation of mentors to future benign urological researchers * 3. Improve the overall level of mentoring among research mentors * 4. Share the successful aspects of our KURe Scholars Program with other institutions across the country Our approach to accomplish these goals is outlined in detail in the application. Though the exact number of KURe funded scholars will vary year-to-year based upon availability of scholars, we anticipate that in an idealized setting, we would have 4 KURe funded scholars: 2 junior faculty (MD or MD/PhD), one post- residency fellow (MD or MD/PhD), and one senior post-doctoral researcher (PhD). The Duke KURe program builds on institutional strengths by providing a large and diverse mentoring pool. Indeed, Duke is ideally positioned to train the next generation of leaders in the field of benign urological research. While the initial funding period for the Duke KURe Scholar Program is for 5 years, we are hopeful that through successfully training urological research scholars and helping they achieve future academic success that we will be able to continue our KURe funding indefinitely.
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会议论文
A randomized controlled phase 2 study of the ketogenic diet for patients with newly diagnosed glioblastoma in combination with standard-of-care treatment
  • 批准号:
    10568656
  • 项目类别:
  • 资助金额:
    $73.91万
  • 财政年份:
    2023
  • 负责人:
    Stephen Jay Freedland
  • 依托单位:
KUH-ART: Advanced Research Training in Kidney disease, Urology and Hematology
Racial Differences in Prostate Cancer Molecular Subtyping
  • 批准号:
    10381279
  • 项目类别:
  • 资助金额:
    $8.5万
  • 财政年份:
    2021
  • 负责人:
    Stephen Jay Freedland
  • 依托单位:
Racial Differences in Prostate Cancer Molecular Subtyping
  • 批准号:
    9889065
  • 项目类别:
  • 资助金额:
    $55.03万
  • 财政年份:
    2018
  • 负责人:
    Stephen Jay Freedland
  • 依托单位:
国内基金
海外基金
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data