Midcareer Investigator Award

职业生涯中期研究员奖

• 批准号: 8531887
• 负责人: Stephen Jay Freedland
• 金额: $ 17.55万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-16 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531887
• 关键词: Adverse effects; Affect; Aftercare; Androgens; Award; Biological Markers; Body Weight; Body Weight decreased; C-reactive protein; Cancer Biology; Cancer Patient; Carbohydrates; Clinical; Clinical Trials; Cohort Studies; Diet; Disease; Disease Progression; Exercise; Faculty; Fatty acid glycerol esters; Funding; Future; Generations; Goals; Growth; Human; In Vitro; Insulin; Intake; Intervention; Intervention Studies; Leptin; Life Style; Link; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mediator of activation protein; Medical Oncology; Medical Students; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Morbidity - disease rate; Mus; Natural History; Obesity; Outcome; Patients; Phase; Pilot Projects; Pomegranate; Population; Process; Prostate Cancer therapy; Prostatic; Public Health; Radical Prostatectomy; Recurrence; Research; Research Personnel; Research Training; Risk; Role; Scientist; Serum; Source; Surgeon; Testing; Time; Toxic effect; Training; Urologist; Urology; Weight; adiponectin; arm; cancer therapy; career; clinical care; deprivation; diet and exercise; dietary restriction; dietary supplements; glycemic control; improved; insulin signaling; lifestyle intervention; meetings; men; next generation; oxidative damage; patient oriented research; prevent; primary outcome; programs; prospective; randomized trial; secondary outcome; trial comparing; tumor progression; urologic

DESCRIPTION (provided by applicant): This Midcareer Investigator Award application seeks support to provide Dr. Freedland with protected time for patient-oriented research (POR) and to act as research mentor for junior faculty and 1 research fellow per year. Dr. Freedland's POR focuses on retrospective cohort studies with a transitioning emphasis on prospective clinical trials aimed at developing new and less toxic treatments to minimize prostate cancer treatment side effects and slow prostate cancer progression. Herein, he proposes a new trial comparing a carbohydrate-restricted diet vs. control for men with PSA recurrence after prostate cancer therapy aiming to slow the rate of PSA rise (lengthen the PSA doubling time), as an indirect measure of slowed prostate cancer growth. Secondary outcomes include weight loss and important prostate cancer biomarkers. Successful completion of this award will advance our understanding of lifestyle and other low toxicity interventions for prostate cancer as well as help educate the next generation of POR investigators.

描述（由申请人提供）：这项职业中期研究者奖申请旨在为弗里兰德博士提供受保护的时间进行面向患者的研究（POR），并担任初级教师的研究导师和每年一名研究员。Freedland博士的POR专注于回顾性队列研究，过渡强调前瞻性临床试验，旨在开发新的毒性较小的治疗方法，以最大限度地减少前列腺癌治疗的副作用并减缓前列腺癌的进展。在此，他提出了一项新的试验，比较碳水化合物限制饮食与对照组在前列腺癌治疗后PSA复发的男性，旨在减缓PSA上升速度（延长PSA倍增时间），作为减缓前列腺癌生长的间接措施。次要结果包括体重减轻和重要的前列腺癌生物标志物。这个奖项的成功完成将促进我们对生活方式和其他低毒性干预前列腺癌的理解和帮助