Midcareer Investigator Award

描述（由申请人提供）：此中期职业研究者奖申请寻求支持，为Freedland博士提供受保护的时间进行以患者为导向的研究（POR），并担任初级教师和每年1名研究员的研究导师。Freedland博士的POR专注于回顾性队列研究，过渡强调前瞻性临床试验，旨在开发新的毒性较小的治疗方法，以最大限度地减少前列腺癌治疗副作用并减缓前列腺癌进展。在此，他提出了一项新的试验，比较了限制碳水化合物饮食与控制前列腺癌治疗后PSA复发的男性，旨在减缓PSA上升的速度（延长PSA倍增时间），作为减缓前列腺癌生长的间接措施。次要结果包括体重减轻和重要的前列腺癌生物标志物。该奖项的成功完成将促进我们对生活方式和其他前列腺癌低毒性干预措施的理解， 教育下一代POR研究人员。

DESCRIPTION (provided by applicant): This Midcareer Investigator Award application seeks support to provide Dr. Freedland with protected time for patient-oriented research (POR) and to act as research mentor for junior faculty and 1 research fellow per year. Dr. Freedland's POR focuses on retrospective cohort studies with a transitioning emphasis on prospective clinical trials aimed at developing new and less toxic treatments to minimize prostate cancer treatment side effects and slow prostate cancer progression. Herein, he proposes a new trial comparing a carbohydrate-restricted diet vs. control for men with PSA recurrence after prostate cancer therapy aiming to slow the rate of PSA rise (lengthen the PSA doubling time), as an indirect measure of slowed prostate cancer growth. Secondary outcomes include weight loss and important prostate cancer biomarkers. Successful completion of this award will advance our understanding of lifestyle and other low toxicity interventions for prostate cancer as well as help educate the next generation of POR investigators.