TRANSGENIC SOYBEAN FORMULA TO ENHANCE RESECTION-INDUCED INTESTINAL ADAPTATION

转基因大豆配方可增强切除引起的肠道适应

• 批准号: 8475594
• 负责人: BRAD Wayne WARNER
• 金额: $ 21.98万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8475594
• 关键词: Address; Ally; Animal Model; Animal Testing; Area; Bacteria; Biological Products; Biotechnology; Catheters; Cessation of life; Coagulation Process; Collaborations; Development; Digestion; Drug Compounding; Drug Formulations; EGFR inhibition; Enteral; Enteral Feeding; Enterocytes; Epidermal Growth Factor; Epidermal Growth Factor Receptor; Excision; Foundations; Genetic Engineering; Goals; Human; Infection; Intestines; Intravenous; Kilogram; Laboratories; Length; Liver; Liver Failure; Medical; Milk; Modeling; Morbidity - disease rate; Mus; Nutrient; Operative Surgical Procedures; Oral; Patients; Pediatric Hospitals; Peptides; Pharmacologic Substance; Physicians; Plants; Postoperative Period; Process; Production; Proteins; Research Personnel; Resources; Risk; Rodent Model; Safety; Science; Scientist; Short Bowel Syndrome; Signal Transduction; Small Intestines; Solutions; Soy Milk; Soybeans; Surface; System; Testing; Time; Total Parenteral Nutrition; Toxic effect; Transgenic Organisms; Transplantation; Universities; Veins; Villus; Washington; Weaning; Yeasts; absorption; base; cost; cost effective; experience; forging; improved; liver injury; medical schools; minimal risk; novel; novel strategies; nutrition; prevent; receptor; research study; response; soy; tube feeding

DESCRIPTION (provided by applicant): Short gut syndrome (SGS) results from the massive intestinal resection that is often necessary in a broad array of medical and surgical treatments. Following a massive small bowel resection (SBR), a compensatory process occurs in the remnant bowel termed adaptation. This response is largely a mitogenic signal culminating in taller villi, deeper crypts, and an expanded mucosal absorptive and digestive surface area. The significance of adaptation is underscored by the requirement in SGS patients of nutrition by vein for the duration of the patient's lifetime if this response is inadequate. It has been demonstrated that exogenous EGF enhances several morphologic parameters of adaptation and its use has been proposed as a treatment for SGS. A unique collaboration between researchers at the Donald Danforth Plant Science Center and physician scientists at the St. Louis Children's Hospital and Washington University School of Medicine will develop and do animal testing of a soy-milk formula produced from soybeans genetically engineered to synthesize EGF. This novel transgenic EGF soy-based formula may provide a low-cost, minimal-risk therapy for SBR patients as a means to reduce SGS. Plant-based production would have many advantages in terms of production costs, world-wide distribution, and stability. This approach may provide a simple means of reducing SGS, and the associated high-cost most often borne by public resources.

描述（由申请人提供）：短肠综合征（SGS）是由大量肠道切除术引起的，这在广泛的医学和外科治疗中经常是必要的。在大量小肠切除（SBR）后，残肠中发生一种称为适应的代偿过程。这种反应主要是一个有丝分裂的信号，最终导致绒毛变高，隐窝变深，粘膜吸收和消化表面积扩大。如果这种反应不充分，SGS患者一生中需要静脉营养，这就强调了适应的重要性。已经证明了