Symphony Automated 12 Channel Solid Phase Bio-Organic Synthesizer

描述（由申请人提供）：波士顿生物医学研究所（BBRI）的研究人员从事各种各样的研究兴趣，其统一目标是阐明在人类疾病中出错的正常细胞和分子机制。癌症生物学，再生生物学，心血管生物学和综合蛋白质生物学的研究方向是为了实现生物医学和医学疗法的新进展。为了提高生物医学研究项目的质量和范围，BBRI的研究人员正在申请资金购买由Protein Technologies，Inc.制造的Symphony自动化12通道固相生物有机合成仪。该仪器是最先进的肽合成仪，能够同时合成多达12种肽。每个合成都可以定制设计，以允许分配独特的偶联时间，重复偶联等，以提高最终产品的质量。该仪器的另一个特点是，它允许肽合成的规模从5 μ M到3 mM。交响乐仪器将被安置在实验室的监督P. I。他目前领导着研究所的肽核心。他 他的技术助理将负责该仪器的日常运行和维护;将在肽设计和合成战略方面提供持续的咨询和援助;并向其他潜在用户提供适当的培训。BBRI的研究委员会（COR）将提供额外的一般监督和使用审查，该委员会是一个内部科学咨询委员会，由代表BBRI全方位研究兴趣和专业知识的教师组成。BBRI一贯支持肽合成，并致力于提供空间，服务合同和运营成本，以支持新仪器。11个BBRI研究项目将在收购交响乐乐器后实现立即和持续的加速进展。其中包括7名R 01级受资助的高级和初级研究者的研究项目，他们将成为主要用户，以及4名次要用户，包括3名新研究者的新兴研究项目。该仪器还将加强总部设在BBRI的Wellstone合作肌肉营养不良研究中心的研究。

DESCRIPTION (provided by applicant): Investigators at Boston Biomedical Research Institute (BBRI) pursue a diverse range of research interests that have the unifying goal of elucidating normal cellular and molecular mechanisms that go awry in human disease. Institute-wide, programmatic research thrusts in Cancer Biology, Regenerative Biology, Cardiovascular Biology, and Integrative Protein Biology are motivated by the intent to enable new advances in biomedicine and medical therapies. To enhance the quality and scope of their biomedical research programs, investigators at BBRI are applying for funds to purchase a Symphony Automated 12-Channel Solid Phase Bio-Organic Synthesizer manufactured by Protein Technologies, Inc. This instrument is a state-of-the-art peptide synthesizer that has the capability to synthesize up to 12 peptides simultaneously. Each synthesis can be custom designed to allow assigning unique coupling times, repeat couplings, etc, to enhance the quality of the final products. Another feature of the instrument is that it allows peptides to be synthesized at scales ranging from 5 uM to 3 mM. The Symphony instrument will be housed within the laboratory of the overseeing P.I. who currently directs the Institute's Peptide Core. He and his technical associate would be responsible for the day-to-day operation and maintenance of the instrument; would provide ongoing consultation and assistance in peptide design and synthesis strategies; and provide proper training to other potential users. Additional general oversight and usage review will be provided by BBRI's Committee on Research (COR), which is an internal scientific advisory committee composed of faculty who represent the full range of research interests and expertise at BBRI. BBRI has consistently supported peptide synthesis and is committed to providing space, service contracts, and operational costs for support of the new instrument. Eleven BBRI research programs will realize an immediate and sustained acceleration of progress upon acquisition of the Symphony Instrument. These include the research programs of 7 R01-level, funded senior and junior investigators, who will be major users, and 4 minor users, including the emerging research programs of 3 new investigators. The instrument will also enhance research in a Wellstone Cooperative Muscular Dystrophy Research Center headquartered at BBRI.