Mechanistic mixture models of mechanics of morphogenesis with murine measurement

小鼠测量形态发生力学的机械混合模型

• 批准号: 8284300
• 负责人: SHARON R LUBKIN
• 金额: $ 32.67万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8284300
• 关键词: Area; Cells; Collaborations; Development; Diffusion; Duct (organ) structure; Embryo; Epithelium; Health; Kidney; Life; Lung; Malignant Neoplasms; Mammary gland; Measurement; Mechanics; Methods; Modeling; Morphogenesis; Mus; Organ; Organism; Rest; System; Testing; Time; Tissues; Work; Wound Healing; angiogenesis; insight; lung development; reconstruction

DESCRIPTION (provided by applicant): Objectives: The living world is embedded in the physical world. Small organisms live in a world of diffusion. The rest of us require a system of ducts for transport of all the materials we need to live. Systems of branched ducts are found in lung, kidney, mammary gland, and many other organs. This project's primary objective is to understand the mechanisms of tissue dynamics that create branched systems. It also aims to clarify the best ways to work with continuum mechanical models of morphogenesis to realistically describe mechanics and transport in developing tissues. Additionally, the project will develop new numerical methods for mixture models with interfaces. We will then test these models in a real time living branching system, the early embryonic lung. Aim 1: Develop accurate, stable, efficient methods for solving mixture problems with sharp interfaces. Aim 2: Develop a suite of models of the mechanical aspects of branching epithelia.

描述（申请人提供）：目标：生活世界嵌入了物理世界中。小生物生活在一个扩散世界中。我们其余的人需要一个管道系统，以运输我们需要使用的所有材料。在肺，肾脏，乳腺和许多其他器官中发现了分支导管的系统。该项目的主要目标是了解创建分支系统的组织动力学机制。它还旨在阐明与形态发生的连续机械模型合作的最佳方法，以实际描述发展组织中的力学和运输。此外，该项目将开发与界面混合模型的新数值方法。然后，我们将在实时生存的分支系统（早期胚胎肺）中测试这些模型。 目标1：开发准确，稳定，有效的方法来解决与尖锐界面的混合问题。 目标2：开发一组分支上皮的机械方面的模型。