Translational and Clinical Research

转化和临床研究项目的目标是从基础科学中带来新的见解 Siteman癌症中心的创新临床试验计划将对 改善患者的肿瘤护理。我们特别强调的是利用来自信号的信息 途径，（例如子宫内膜癌中的FGFR 2，胶质母细胞瘤中的NF 1和甲状腺癌中的RET）。Genomics (lung癌症、胶质母细胞瘤、前列腺癌和直肠癌）和肿瘤成像（前列腺癌、肺癌、 食管癌和甲状腺癌）用于临床研究的设计、分析和解释 试验和研究。该方案还促进了与预防和控制方案的合作 并在前列腺癌筛查等领域获得了赠款、出版物和临床项目 和共病研究。转化和临床研究计划提供了支持网络， 一个不断扩大的发展治疗学项目，重点是机构0、1和II期研究。的 该计划还支持基于疾病的工作组开发、审查、优先考虑和进行临床试验 研究，特别强调肺癌、子宫内膜癌、前列腺癌和胃肠道癌的工作组， 神经肿瘤科此外，转化和临床研究计划将提供以下培训： 各级经验的调查员，并促进教育机会，包括研讨会，课程， 务虚会、期刊俱乐部、研讨会和工作进展会议。 转化和临床研究计划有来自15个部门和2所学校的74名成员。的 该计划获得24，979，138美元的资金支持，其中NCI资金11，438，989美元，NCI资金10，835，323美元 其他同行评审资金。在上一个资助期内，转化和临床研究的成员 方案出版了1，157份手稿，其中24.90%是方案间的，23.43%是结果性的。 从项目内部合作中。

The goal ofthe Translational & Clinical Research Program is to bring new insights from Basic Sciences Programs ofthe Siteman Cancer Center into innovative clinical trials that will have an important impact on improving oncologic care for patients. Our particular emphasis is on utilizing information from Signaling Pathways, (eg FGFR2 in endometrial cancer, NF1 in glioblastoma, and RET in thyroid cancer). Genomics (lung cancer, glioblastoma, prostate cancer and rectal cancer), and Oncologic Imaging (prostate cancer, lung and esophageal cancers, and thyroid cancer) for the design, analysis, and interpretation of clinical research trials and studies. Collaborations with the Prevention and Control Program are also fostered by this program and have resulted in grants, publications and clinical projects from areas including prostate cancer screening and co-morbidity studies. The Translational & Clinical Research Program provides the supporting network for an expanding Developmental Therapeutics Program focused on institutional phase 0,1, and II studies. The program also supports disease-based working groups to develop, review, prioritize, and conduct clinical trials research, with special emphasis on working groups in lung, endometrial, prostate, and Gl cancer, and Neuro-Oncology. Furthermore, the Translational & Clinical Research Program will provide training of investigators at all levels of experience and foster educational opportunities including seminars, courses, retreats, journal clubs, workshops, and work-in-progress meetings. The Translational & Clinical Research Program has 74 members from 15 Departments and 2 Schools. The Program is supported by $24,979,138 in funding of which $11,438,989 in NCI funding and $10,835,323 in other peer reviewed funding. In the last grant period, members of the Translational & Clinical Research Program published 1,157 manuscripts, of which 24.90% represent inter-programmatic and 23.43% resulted from intra-programmatic collaborations.