The Use of Novel Technologies to Investigate Bone Health in Diabetes Mellitus

使用新技术研究糖尿病患者的骨骼健康

• 批准号: 8290321
• 负责人: Laura Anne Graeff Armas
• 金额: $ 13.06万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8290321
• 关键词: Affect; Age; Alkaline Phosphatase; American; Anabolic Agents; Antibodies; Biochemical; Biometry; Biopsy; Biopsy Specimen; Blood Glucose; Bone Density; Bone Diseases; Bone Mineral Contents; Bone Resorption; Bone remodeling; Calcium; Cardiovascular system; Case-Control Studies; Celiac Disease; Clinical; Clinical Endocrinology; Clinical Research; Creatinine; Cyclophosphamide; Data; Diabetes Mellitus; Diabetic mouse; Dietary Factors; Disease; Dual-Energy X-Ray Absorptiometry; Electrolytes; Endocrinology; Enrollment; Enzymes; Epidemiology; Estradiol; Family; Fellowship; Female; Fluorochrome; Fracture; Frequencies; General Population; Glucose; Glycosylated Hemoglobin; Goals; Health; Hip region structure; Human; Instruction; Insulin-Dependent Diabetes Mellitus; Insulin-Like Growth Factor I; Internal Medicine; K-Series Research Career Programs; Kidney; Knowledge; Label; Laboratories; Lead; Life Expectancy; Liver; Master of Public Health; Measures; Mentors; Metabolism; Methods; Modeling; Nervous system structure; Osteocalcin; Osteogenesis; Osteoporosis; Outcome; Patients; Peripheral; Phosphorus; Physicians; Population; Prevalence; Prevention; Procedures; Publishing; Rattus; Recording of previous events; Recruitment Activity; Research; Research Design; Research Personnel; Research Project Grants; Risk; Scientist; Serum; Structure; Techniques; Testosterone; Tetracyclines; Thyroid Function Tests; Time; Training; Translational Research; Trauma; Treatment Factor; United States; Universities; Urea Nitrogen; Vertebral column; Work; X-Ray Computed Tomography; bone; bone health; bone mass; bone strength; bone turnover; career; density; design; diabetes control; diabetic; diabetic patient; experience; human study; lifestyle factors; male; new technology; programs; prospective; repaired; sex; skeletal; skills; type I diabetic; urinary

Dr, Armas has spent considerable time developing her research and professional career by completing a clinical endocrinology fellowship, becoming American Board of Internal Medicine certified in Endocrinology, Diabetes and Metabolism, and completing, presenting and publishing clinical research projects. Her long- term goals are to be an academic physician-scientist conducting clinical translational research in the field of bone disease and to be expert in state-of-the-art methods of bone analysis. This mentored K award includes a Masters of Public Health with a concentration in biostatistics and epidemiology. It is also focused on the technological skills needed in the bone research field, including training in transilial bone biopsy procedure, histomorphometry, micro-computed tomography (micro-CT), and peripheral quantitative computed tomography (pQCT). Creighton University Osteoporosis Research Center is a unique place to study bone with over 45 years of clinical research experience. Dr. Robert R. Recker has been instrumental in furthering research in the bone field. The skills and and knowledge needed to build an academic career in research are being used every day by dozens of people in and affiliated with the research center. This mentored research project is designed to use the technological skills and knowledge of statistical design and research and apply them to the problem of bone disease in patients with diabetes. This is a prospective, case-control study of diabetic subjects using DXA, bone markers, pQCT, histomorphometry, and micro-CT of transilial bone biopsies. This human study is designed to elucidate the effect of Type 1 diabetes on 1) bone remodeling, including histomorphometric and biochemical measures of bone formation and resorption, and 2) on structure, including micro-architectural arrangement of trabeculae and bone mineral density. RELEVANCE (See Instructions): Diabetics have higher rates of fracture than the general population. The mechanism is uncertain. Studies of human bone mass and rat. models of diabetes point to reduced bone turnover that leads to fragility and fractures. This has not been shown in humans. This will be the first study in humans of diabetic bone disease using histomorphometry, micro-CT and pQCT to elucidate the mechanisms of bone fragility. This will lead to further research in prevention and treatment of bone disease in patients with diabetes.

阿马斯博士花了相当长的时间发展她的研究和职业生涯，完成了一项 临床内分泌学奖学金，成为美国内科委员会认证的内分泌学， 糖尿病和代谢，并完成，提出和出版临床研究项目。她的长- 长期目标是成为一名学术医生，科学家在该领域进行临床转化研究 骨骼疾病，并成为最先进的骨骼分析方法的专家。这一指导K奖包括 公共卫生硕士，主修生物统计学和流行病学。它还侧重于 骨研究领域所需的技术技能，包括经髂骨骨活检程序的培训， 组织形态计量学、显微计算机断层扫描（micro-CT）和外周定量计算机 断层扫描（pQCT）。 Creighton大学骨质疏松症研究中心是一个独特的研究骨骼的地方，拥有超过45年的 临床研究经验。Robert R. Recker一直致力于进一步研究骨骼 领域在研究中建立学术生涯所需的技能和知识正在被使用， 每天都有几十个人在研究中心工作。 这个指导研究项目的目的是使用统计设计的技术技能和知识 研究并应用于糖尿病患者的骨病问题。这是一个前瞻性的， 使用DXA、骨标记物、pQCT、组织形态计量学和显微CT对糖尿病受试者进行的病例对照研究 髂骨活检这项人体研究旨在阐明1型糖尿病对1） 骨重建，包括骨形成和再吸收的组织形态学和生物化学测量， 2）结构方面，包括骨小梁的微结构排列和骨密度。 相关性（见说明）： 糖尿病患者的骨折率高于普通人群。机制不确定。研究 人骨质量和大鼠。糖尿病模型指出，骨转换减少，导致脆弱性， 骨折这在人类身上还没有表现出来。这将是第一个在人类糖尿病骨骼疾病的研究 采用组织形态计量学、micro-CT和pQCT等方法，探讨骨脆性的发生机制。这将导致 进一步研究糖尿病患者骨病的预防和治疗。