The Use of Novel Technologies to Investigate Bone Health in Diabetes Mellitus

简介(申请人提供)：阿尔马斯博士花了相当长的时间发展她的研究和职业生涯，完成了临床内分泌学奖学金，成为美国内科委员会内分泌学、糖尿病和新陈代谢方面的认证，并完成、提交和发表临床研究项目。她的长期目标是成为一名学术内科医生兼科学家，在骨骼疾病领域进行临床转化研究，并成为最先进的骨骼分析方法专家。这个辅导性K奖包括公共卫生硕士，专业是生物统计学和流行病学。它还侧重于骨研究领域所需的技术技能，包括过渡性骨活组织检查程序、组织形态计量学、微型计算机断层扫描(Micro-CT)和外周定量计算机断层扫描(PQCT)的培训。克雷顿大学骨质疏松症研究中心是研究骨骼的独特场所，拥有超过45年的临床研究经验。罗伯特·R·雷克尔博士在推动骨骼领域的研究方面发挥了重要作用。在研究中心和附属于研究中心的数十人每天都在使用在研究领域建立学术生涯所需的技能和知识。这个有指导的研究项目旨在利用统计设计和研究的技术技能和知识，并将其应用于糖尿病患者的骨病问题。这是一项针对糖尿病受试者的前瞻性病例对照研究，采用DXA、骨标记物、pQCT、组织形态计量学和间歇性骨活检的显微CT。这项人类研究旨在阐明1型糖尿病对骨重建的影响，包括骨形成和骨吸收的组织形态计量学和生化指标，以及2)结构的影响，包括骨小梁的微结构安排和骨密度。

DESCRIPTION (provided by applicant): Dr. Armas has spent considerable time developing her research and professional career by completing a clinical endocrinology fellowship, becoming American Board of Internal Medicine certified in Endocrinology, Diabetes and Metabolism, and completing, presenting and publishing clinical research projects. Her long-term goals are to be an academic physician-scientist conducting clinical translational research in the field of bone disease and to be expert in state-of-the-art methods of bone analysis. This mentored K award includes a Masters of Public Health with a concentration in biostatistics and epidemiology. It is also focused on the technological skills needed in the bone research field, including training in transilial bone biopsy procedure, histomorphometry, micro-computed tomography (micro-CT), and peripheral quantitative computed tomography (pQCT). Creighton University Osteoporosis Research Center is a unique place to study bone with over 45 years of clinical research experience. Dr. Robert R. Recker has been instrumental in furthering research in the bone field. The skills and knowledge needed to build an academic career in research are being used every day by dozens of people in and affiliated with the research center. This mentored research project is designed to use the technological skills and knowledge of statistical design and research and apply them to the problem of bone disease in patients with diabetes. This is a prospective, case-control study of diabetic subjects using DXA, bone markers, pQCT, histomorphometry, and micro-CT of transilial bone biopsies. This human study is designed to elucidate the effect of Type 1 diabetes on 1) bone remodeling, including histomorphometric and biochemical measures of bone formation and resorption, and 2) on structure, including micro-architectural arrangement of trabeculae and bone mineral density.