The Use of Novel Technologies to Investigate Bone Health in Diabetes Mellitus

使用新技术研究糖尿病患者的骨骼健康

• 批准号: 7912994
• 负责人: Laura Anne Graeff Armas
• 金额: $ 13.03万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7912994
• 关键词: Affect; Age; Alkaline Phosphatase; American; Anabolic Agents; Antibodies; Arts; Biochemical; Biometry; Biopsy; Biopsy Specimen; Blood Glucose; Bone Density; Bone Diseases; Bone Mineral Contents; Bone remodeling; Calcium; Cardiovascular system; Case-Control Studies; Celiac Disease; Clinical; Clinical Endocrinology; Clinical Research; Creatinine; Cyclophosphamide; Data; Diabetes Mellitus; Diabetic mouse; Dietary Factors; Disease; Dual-Energy X-Ray Absorptiometry; Electrolytes; Endocrinology; Enrollment; Enzymes; Epidemiology; Estradiol; Family history of; Fellowship; Female; Fluorochrome; Fracture; Frequencies; Glucose; Glycosylated Hemoglobin; Goals; Health; Hip region structure; Human; Insulin-Dependent Diabetes Mellitus; Insulin-Like Growth Factor I; Internal Medicine; K-Series Research Career Programs; Kidney; Knowledge; Label; Laboratories; Lead; Life Expectancy; Life Style; Liver; Master of Public Health; Measures; Mentors; Metabolism; Methods; Nervous system structure; Osteocalcin; Osteogenesis; Osteoporosis; Outcome; Patients; Peripheral; Phosphorus; Physicians; Population; Prevalence; Prevention; Procedures; Publishing; Recruitment Activity; Research; Research Design; Research Personnel; Research Project Grants; Risk; Scientist; Serum; Structure; Techniques; Testosterone; Tetracyclines; Thyroid Function Tests; Time; Training; Translational Research; Trauma; United States; Universities; Urea Nitrogen; Vertebral column; Work; X-Ray Computed Tomography; bone; bone health; bone mass; bone strength; bone turnover; career; density; design; diabetes control; diabetic; diabetic patient; experience; human study; male; new technology; programs; prospective; repaired; sex; skeletal; skills; treatment duration; type I diabetic; urinary

DESCRIPTION (provided by applicant): Dr. Armas has spent considerable time developing her research and professional career by completing a clinical endocrinology fellowship, becoming American Board of Internal Medicine certified in Endocrinology, Diabetes and Metabolism, and completing, presenting and publishing clinical research projects. Her long-term goals are to be an academic physician-scientist conducting clinical translational research in the field of bone disease and to be expert in state-of-the-art methods of bone analysis. This mentored K award includes a Masters of Public Health with a concentration in biostatistics and epidemiology. It is also focused on the technological skills needed in the bone research field, including training in transilial bone biopsy procedure, histomorphometry, micro-computed tomography (micro-CT), and peripheral quantitative computed tomography (pQCT). Creighton University Osteoporosis Research Center is a unique place to study bone with over 45 years of clinical research experience. Dr. Robert R. Recker has been instrumental in furthering research in the bone field. The skills and knowledge needed to build an academic career in research are being used every day by dozens of people in and affiliated with the research center. This mentored research project is designed to use the technological skills and knowledge of statistical design and research and apply them to the problem of bone disease in patients with diabetes. This is a prospective, case-control study of diabetic subjects using DXA, bone markers, pQCT, histomorphometry, and micro-CT of transilial bone biopsies. This human study is designed to elucidate the effect of Type 1 diabetes on 1) bone remodeling, including histomorphometric and biochemical measures of bone formation and resorption, and 2) on structure, including micro-architectural arrangement of trabeculae and bone mineral density.

描述（由申请人提供）：阿马斯博士花了相当多的时间通过完成临床内分泌学奖学金来发展她的研究和职业生涯，成为美国内科委员会认证的内分泌学，糖尿病和代谢，并完成，提出和出版临床研究项目。她的长期目标是成为一名在骨骼疾病领域进行临床转化研究的学术医生-科学家，并成为最先进的骨骼分析方法的专家。这个指导K奖包括公共卫生硕士学位，专注于生物统计学和流行病学。它还专注于骨研究领域所需的技术技能，包括translial骨活检程序，组织形态学，微型计算机断层扫描（micro-CT）和外周定量计算机断层扫描（pQCT）的培训。Creighton University骨质疏松症研究中心是一个独特的研究骨骼的地方，拥有超过45年的临床研究经验。Robert R.雷克在骨骼领域的进一步研究中发挥了重要作用。建立研究学术生涯所需的技能和知识每天都被研究中心的数十名人员使用。该指导研究项目旨在使用统计设计和研究的技术技能和知识，并将其应用于糖尿病患者的骨骼疾病问题。这是一项糖尿病受试者的前瞻性病例对照研究，使用DXA、骨标记物、pQCT、组织形态计量学和经髂骨活检的micro-CT。这项人体研究旨在阐明1型糖尿病对1）骨重建的影响，包括骨形成和吸收的组织形态学和生物化学指标，以及2）对结构的影响，包括骨小梁的微结构排列和骨矿物质密度。