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The Use of Novel Technologies to Investigate Bone Health in Diabetes Mellitus

使用新技术研究糖尿病患者的骨骼健康

基本信息

批准号：
8506974
负责人：
Laura Anne Graeff Armas
金额：
$ 13.06万
依托单位：
CREIGHTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-15 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8506974
关键词：
Affect Age Alkaline Phosphatase American Anabolic Agents Antibodies Biochemical Biometry Biopsy Biopsy Specimen Blood Glucose Bone Density Bone Diseases Bone Mineral Contents Bone Resorption Bone remodeling Calcium Cardiovascular system Case-Control Studies Celiac Disease Clinical Clinical Endocrinology Clinical Research Creatinine Cyclophosphamide Data Diabetes Mellitus Diabetic mouse Dietary Factors Disease Dual-Energy X-Ray Absorptiometry Electrolytes Endocrinology Enrollment Enzymes Epidemiology Estradiol Family Fellowship Female Fluorochrome Fracture Frequencies General Population Glucose Glycosylated Hemoglobin Goals Health Hip region structure Human Instruction Insulin-Dependent Diabetes Mellitus Insulin-Like Growth Factor I Internal Medicine K-Series Research Career Programs Kidney Knowledge Label Laboratories Lead Life Expectancy Liver Master of Public Health Measures Mentors Metabolism Methods Modeling Nervous system structure Osteocalcin Osteogenesis Osteoporosis Outcome Patients Peripheral Phosphorus Physicians Population Prevalence Prevention Procedures Publishing Rattus Recording of previous events Recruitment Activity Research Research Design Research Personnel Research Project Grants Risk Scientist Serum Structure Techniques Testosterone Tetracyclines Thyroid Function Tests Time Training Translational Research Trauma Treatment Factor United States Universities Urea Nitrogen Vertebral column Work X-Ray Computed Tomography bone bone health bone mass bone strength bone turnover career density design diabetes control diabetic diabetic patient experience human study lifestyle factors male new technology programs prospective repaired sex skeletal skills type I diabetic urinary

项目摘要

Dr, Armas has spent considerable time developing her research and professional career by completing a clinical endocrinology fellowship, becoming American Board of Internal Medicine certified in Endocrinology, Diabetes and Metabolism, and completing, presenting and publishing clinical research projects. Her long- term goals are to be an academic physician-scientist conducting clinical translational research in the field of bone disease and to be expert in state-of-the-art methods of bone analysis. This mentored K award includes a Masters of Public Health with a concentration in biostatistics and epidemiology. It is also focused on the technological skills needed in the bone research field, including training in transilial bone biopsy procedure, histomorphometry, micro-computed tomography (micro-CT), and peripheral quantitative computed tomography (pQCT). Creighton University Osteoporosis Research Center is a unique place to study bone with over 45 years of clinical research experience. Dr. Robert R. Recker has been instrumental in furthering research in the bone field. The skills and and knowledge needed to build an academic career in research are being used every day by dozens of people in and affiliated with the research center. This mentored research project is designed to use the technological skills and knowledge of statistical design and research and apply them to the problem of bone disease in patients with diabetes. This is a prospective, case-control study of diabetic subjects using DXA, bone markers, pQCT, histomorphometry, and micro-CT of transilial bone biopsies. This human study is designed to elucidate the effect of Type 1 diabetes on 1) bone remodeling, including histomorphometric and biochemical measures of bone formation and resorption, and 2) on structure, including micro-architectural arrangement of trabeculae and bone mineral density. RELEVANCE (See Instructions): Diabetics have higher rates of fracture than the general population. The mechanism is uncertain. Studies of human bone mass and rat. models of diabetes point to reduced bone turnover that leads to fragility and fractures. This has not been shown in humans. This will be the first study in humans of diabetic bone disease using histomorphometry, micro-CT and pQCT to elucidate the mechanisms of bone fragility. This will lead to further research in prevention and treatment of bone disease in patients with diabetes.

Armas博士花了相当多的时间来发展她的研究和职业生涯，完成了一个