Translational Science BioCore

转化科学BioCore

• 批准号: 8483744
• 负责人: GEORGE WILDING
• 金额: $ 16.5万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-25 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8483744
• 关键词: Basic Science; Biomedical Research; Blood; Cancer Center; Collection; Comprehensive Cancer Center; Confidentiality; Fluorescence; Fostering; Grant; Histology; Human; Immunohistochemistry; Individual; Instruction; Malignant Neoplasms; Molecular; National Cancer Institute; Pathology; Procedures; Process; Research; Research Personnel; Resources; Safety; Services; Tissue Microarray; Tissues; Translational Research; Universities; Wisconsin; biobank; cellular pathology; human tissue; instrument; laser capture microdissection; liquid crystal polymer; molecular pathology

The University of Wisconsin Carbone Cancer Center (UWCCC) Translational Science BioCore (TSB) was established in 2007 to support world class biomedical research at the University of Wisconsin by providing a biorepository with the capability of offering associated histological and molecular services essential for the conduct of translational research. The TSB BioBank provides high-quality human tissues, blood and other biospecimens that are prospectively collected, processed, stored and distributed in accordance with procedures that comply with the confidentiality, safety and all other regulatory standards set by the University of Wisconsin and the National Cancer Institute's Best Practices for Biospecimen Resources. During the current grant period, services have also expanded to provide a wide variety of associated histological cellular and molecular pathology services via the TSB Translational Research Initiatives in Pathology (TRIP) including construction and distribution of tissue microarrays; quantitative morphometric analysis with AQUA, Vectra and Nuance instruments; laser capture microdissection; multispectral fluorescence and bright field immunohistochemistry; and PCR and quantitative RT PCR analyses. The TSB also offers a wide scope of histological and consultative services to support biomedical research. Significant progress has been made toward developing a shared, centralized biorepository with the capability of providing associated histological and molecular analyses and which has already begun to foster translational research at the UWCCC.

威斯康星州大学Carbone癌症中心（UWCCC）转化科学BioCore（TSB）成立于2007年，旨在通过提供具有提供转化研究所必需的相关组织学和分子学服务能力的生物储存库，支持威斯康星州大学的世界级生物医学研究。 TSB生物库提供高质量的人体组织、血液和其他生物标本，这些标本是按照符合威斯康星州大学和国家癌症研究所生物标本资源最佳实践规定的保密、安全和所有其他监管标准的程序进行前瞻性收集、处理、储存和分发的。 在目前的赠款期间，服务也扩大到通过TSB病理学转化研究倡议（TRIP）提供各种相关的组织学细胞和分子病理学服务，包括组织微阵列的构建和分布;使用AQUA，Vectra和Nuance仪器进行定量形态学分析;激光捕获显微切割;多光谱荧光和明场免疫组织化学; PCR和定量RT PCR分析。TSB还提供广泛的组织学和咨询服务，以支持生物医学研究。在开发一个共享的集中式生物储存库方面取得了重大进展，该生物储存库具有提供相关组织学和分子分析的能力，并且已经开始促进UWCCC的转化研究。