Drug Dependence Clinical Research Program

药物依赖性临床研究计划

• 批准号: 8492047
• 负责人: NEAL L BENOWITZ
• 金额: $ 58.13万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8492047
• 关键词: Adenosine; Alcohols; Alkaloids; Analytical Chemistry; Biological Assay; Caffeine; Cancer Grant Supplements (P30); Clinic; Clinical Pharmacology; Clinical Psychology; Clinical Research; Cocaine; Consult; Data Analyses; Discipline; Drug Addiction; Drug Kinetics; Drug abuse; Drug usage; Ephedra; Funding; Grant; Health; Human; Individual; Institution; Institutional Review Boards; Internal Medicine; Label; Laboratories; Manuscripts; Measures; Methamphetamine; Neurology; Nicotine; Opiates; Organic Chemistry; Pediatrics; Persons; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacy facility; Phenethylamines; Preparation; Psychiatry; Psychopharmacology; Psychotropic Drugs; Request for Applications; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Services; Source; Synthesis Chemistry; Toxicogenetics; United States National Institutes of Health; addiction; analytical method; cost effective; drug abuse chemotherapy; drug addict; ecstasy; effective therapy; gamma hydroxybutyrate; heart pharmacology; innovation; interest; neurosteroids; programs; statistics; treatment strategy

DESCRIPTION (provided by applicant): This Core Support Center Grant (P30) application requests continued support for an analytic and synthetic chemistry laboratory and administrative shared core infrastructure. The participating, currently funded, constituent projects continue research programs with human laboratory and treatment clinic studies of the clinical pharmacology of abused drugs, pharmacotherapies and other treatment strategies to treat drug abuse and addictions. Drugs of interest to participating projects and assays available include nicotine and its metabolites, cocaine, methamphetamine and other phenethylamines, alcohol, MDMA, ephedra alkaloids, caffeine, gamma hydroxybutyrate (GHB), salvinorin, adenosine, and neurosteroids, and opiates. Analytical methods have been developed and validated in the core analytic laboratory to support studies with these drugs. Other new assays and labeled (deuterated) compounds will be made available to the associated research projects as needed. Disciplines represented by the participating projects and investigators include psychiatry, clinical psychology, neurology, general internal medicine, cardiology and clinical pharmacology, psychopharmacology, toxicology, genetics, pediatrics, pharmacy, organic, medicinal and analytical chemistry, and statistics. Our aims are: (1) to provide a state-of-the-art well equipped and staffed, analytical and synthetic chemistry laboratory resource for the participating projects of drug abuse researchers at UCSF and at other institutions. (2) To provide administrative support for manuscript preparation, IRB and related regulatory documents, grants management, and other research administrative services of value participating projects. (3) To provide statistical consulting services regarding study design and data analysis strategies, particularly optimal pharmacokinetic analysis to participating projects. The overall objective is to provide sophisticated analytic laboratory resources with stability of support together with adequate administrative support responsive to the needs of individual funded constituent scientific projects as those projects change and evolve. This facility is a cost-effective shared laboratory resource that enhances and extends research possibilities of investigators currently funded by NIH or other federal or nonfederal sources to further our understanding of human psychoactive drug use, abuse and addiction, its health consequences and its treatment management.

描述(由申请人提供)：此核心支持中心拨款(P30)申请继续支持分析和合成化学实验室和行政共享的核心基础设施。参与的、目前得到资助的组成项目继续开展人体实验室和治疗诊所研究滥用药物的临床药理学、药物疗法和其他治疗药物滥用和成瘾的治疗策略的研究计划。现有参与项目和化验方法感兴趣的药物包括尼古丁及其代谢物、可卡因、甲基苯丙胺和其他苯乙胺、酒精、MDMA、麻黄生物碱、咖啡因、羟丁酸(GHB)、萨尔维诺林、腺苷、神经类固醇和阿片类药物。核心分析实验室已经开发和验证了分析方法，以支持这些药物的研究。其他新的分析方法和标记的(氚)化合物将根据需要提供给相关的研究项目。参与项目和研究人员代表的学科包括精神病学、临床心理学、神经学、普通内科、心脏病学和临床药理学、精神药理学、毒理学、遗传学、儿科、药剂学、有机、药物和分析化学以及统计学。我们的目标是：(1)为加州大学旧金山分校和其他机构的药物滥用研究人员参与的项目提供最先进的设备和人员配备的分析和合成化学实验室资源。(2)为价值参与项目的稿件准备、IRB及相关规范性文件、拨款管理等研究行政服务提供行政支持。(3)提供有关研究设计和数据分析策略的统计咨询服务，特别是为参与项目提供最佳药代动力学分析。总的目标是提供复杂的分析实验室资源，并提供稳定的支持，同时提供适当的行政支持，以应对个别资助的组成科学项目的需要，因为这些项目正在变化和发展。该设施是一个具有成本效益的共享实验室资源，它增强和扩大了目前由NIH或其他联邦或非联邦来源资助的调查人员的研究可能性，以加深我们对人类精神活性药物的使用、滥用和成瘾、其健康后果及其治疗管理的理解。