Harvard Trauma Inflammation Training Program

描述（由申请人提供）：本申请旨在为创伤，烧伤和围手术期损伤的T32培训计划提供资金，供3名医学博士和3名博士学员在贝斯以色列女执事医疗中心（BIDMC）和哈佛医学院（HMS）的其他附属教学医院的临床导向的医生科学家和基础研究人员的实验室进行创伤研究。哈佛朗伍德医疗区拥有一系列令人印象深刻的临床和研究设施，这将是一个理想的环境， 提出的T32计划，这将是该领域的第一个。该计划将由创伤，休克和炎症研究领域经验丰富的领导者组成的多学科团队指导。该计划的研究重点是创伤引发的炎症过程和器官衰竭的早期事件，目的是开发新的治疗方法，以防止炎症导致器官功能障碍。我们提出了一个培训计划，将教国家的最先进的免疫学，生物化学，分子生物学知识，和先天免疫反应的创伤。一个长期目标是培养创伤研究领域的未来领导者，他们具有在该领域取得切实进展所需的必要的跨学科团队合作技能。我们建议通过配对MD和博士学员来教授这些技能。这些对将在密切的跨学科团队工作。MD学员将帮助他们的博士合作伙伴了解创伤护理的实际临床问题;博士学员将教他们的MD合作伙伴如何用前沿科学方法解决这些问题。双方合作伙伴将学习如何有效地相互沟通，以及如何在互利的跨学科研究团队中解决真实的临床问题。对这种创新培训方法的需求是由以下理由驱动的：尽管几十年来进行了大量的研究，但炎症并发症，免疫功能障碍和器官衰竭仍然是创伤后发病率和死亡率的主要原因。临床创伤护理的显着进展以及我们对驱动创伤后炎症的免疫学，细胞和分子过程的理解的巨大改善并没有转化为临床结果的相应改善。造成这一缺陷的一个核心原因是临床和基础研究人员之间的信息流不足。因此，需要一种新的科学培训模式来培养创伤研究的领导者，他们可以通过发展强大的跨学科团队合作技能来弥合这一差距，帮助他们推进该领域并改善创伤后的临床结果。项目负责人本身已经建立了这种跨学科的伙伴关系，因此将成为榜样。他们聚集了一群令人印象深刻的备受尊敬和积极主动的基础研究人员和临床教师，他们将在实验室指导学员。我们提出了一个计划，将主机3 MD和3博士学员至少2年，每个创伤相关的研究实验室。医学博士预计将完成2-3年的普通外科临床培训，并在重症监护，创伤外科或相关专业从事学术生涯。博士候选人将根据记录的兴趣或创伤或炎症研究，免疫学或相关研究领域的经验进行选择。为了促进跨学科的团队工作技能，学员将组成3个团队，每个团队由一名博士和一名MD学员组成。每个团队合作伙伴将在创伤研究的相关主题范围内开展个人项目。将鼓励他们通过共同出席会议、研讨会和讲座建立密切联系。MD学员将指导他们的博士合作伙伴进行临床查房，以深入了解重症创伤患者护理中的实际临床问题。博士生反过来将提供 他们的MD合作伙伴在实验设计和研究策略以及接触新技术方面提供建议和帮助。该培训计划将帮助学员认识到跨学科团队工作的价值，以及密切合作的临床和基础科学家之间的有力信息流的好处。这种培训方法和哈佛朗伍德地区优秀的研究基础设施将帮助我们实现我们的总体目标，即培养一批新的熟练研究人员，他们可以推进创伤研究领域并改善临床创伤护理。

DESCRIPTION (provided by applicant): This application seeks funding for a T32 Training Program in Trauma, Burn, and Peri-operative Injury for 3 MD and 3 PhD trainees who will conduct trauma research in the laboratories of translationally oriented physician scientists and basic researchers at the Beth Israel Deaconess Medical Center (BIDMC) and other affiliated teaching hospitals of Harvard Medical School (HMS). The Harvard Longwood Medical Area holds an impressive array of clinical and research facilities that will be an ideal setting for the proposed T32 program, which will be the first of its kind in this area. The program will be directed by a multidisciplinary team of experienced leaders in the field of trauma, shock, and inflammation research. The research focus of this proposed program is centered on the early events leading to the inflammatory process and organ failure triggered by trauma with the aim of developing novel treatments to prevent inflammation to organ dysfunction. We propose a training program that will teach state-of-the-art knowledge in immunology, biochemistry, molecular biology, and the innate immune response to trauma. A long-term goal is to develop future leaders in the field of trauma research who have the necessary interdisciplinary teamwork skills that are required for to make tangible progress in the field. We propose to teach these skills by pairing MD and PhD trainees. These pairs will work in close interdisciplinary teams. MD trainees will help their PhD partners understand actual clinical problems in trauma care; PhD trainees will teach their MD partners how to address these problems with leading-edge science approaches. Both partners will lean how to communicate effectively with one another and how to solve real clinical problems in mutually beneficial interdisciplinary research teams. The need for this innovative training approach is driven by the following rationale: ¿ despite intense research efforts over several decades, inflammatory complications, immune dysfunction, and organ failure have remained major causes of post-traumatic morbidity and mortality. ¿ Remarkable progress in clinical trauma care and vast improvements in our understanding of the immunological, cellular, and molecular processes that drive post-traumatic inflammation have not translated into corresponding improvements in clinical outcome. ¿ A core reason for this deficit is inadequate information flow among clinical and basic researchers. Thus, a new paradigm of science training is needed to raise leaders in trauma research who can bridge this gap by developing strong interdisciplinary teamwork skills that help them advance the field and improve clinical outcome after trauma. The program directors themselves have established such interdisciplinary partnerships and will therefore serve as role models. They have gathered an impressive group of highly respected and motivated basic researcher and clinical faculty who will mentor trainees in their laboratories. We propose a program that will host 3 MD and 3 PhD trainees for a minimum of 2 years each in trauma related research laboratories. MDs are expected to have completed 2-3 years of clinical training in general surgery and to pursue an academic career in critical care, trauma surgery, or related specialties. PhD candidates will be selected based on documented interest or experience in trauma or inflammation research, immunology, or in related fields of study. In order to promote interdisciplinary team working skills, trainees will form 3 teams consisting of a PhD and MD trainee each. Each team partner will work on individual projects within related topics in trauma research. They will be encouraged to form close ties through joint attendance of conferences, seminars, and lectures. MD trainees will guide their PhD partner on clinical rounds to provide an in-depth understanding of actual clinical problems in the care for critically ill trauma patients. PhD trainees in turn will provide their MD partners with advice and assistance in the design of experiments and research strategies as well as exposure to new technologies. This training program will help trainees recognize the value of interdisciplinary team work and the benefit of vigorous information flow between closely collaborating clinical and basic scientists. This training approach and the excellent research infrastructure in the Harvard Longwood Area will help us achieve our overall goals, namely to develop a new breed of skilled researcher who can advance the field of trauma research and improve clinical trauma care.