Tagging of Histopathology Specimens with Light-Activated RFID p-Chips

使用光激活 RFID p 芯片标记组织病理学样本

• 批准号: 8542871
• 负责人: WLODEK MANDECKI
• 金额: $ 59.25万
• 依托单位: PHARMASEQ, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8542871
• 关键词: Adherence; Adhesives; Adoption; Amplifiers; Appearance; Area; Benchmarking; Charge; Chemicals; Clinical Trials; Communication; Computer software; Computers; Contractor; Custom; Databases; Diagnostic; Docking; Electronics; Epoxy Compounds; Evaluation; Feedback; Frequencies; Glass; Goals; Hand; Histopathology; Hospitals; Human Resources; Hybrids; Institution; Label; Laboratories; Lasers; Light; Link; Liquid substance; Maintenance; Manufacturer Name; Mechanics; Medical; Medical Research; Methods; Molds; Noise; Optics; Pathology; Performance; Play; Polypropylenes; Printing; Process; Protocols documentation; Provider; Readability; Reader; Reading; Research; Retrieval; Robot; Robotics; Role; Sampling; Scanning; Side; Signal Transduction; Silicon; Slide; Solutions; Solvents; Source; Specimen; System; Systems Development; Technology; Temperature; Testing; Texas; Tissue Sample; Tissue Stains; Tissues; Update; Validation; Wireless Technology; Work; anticancer research; base; chemical stability; cost; design; drug discovery; improved; instrument; knowledge base; lens; programs; prototype; validation studies

DESCRIPTION (provided by applicant): The purpose of the present project is to develop and validate the use of ultra-small RFID chips to tag and track tissue cassettes and glass slides that are used in histopathology laboratories. The system is based on the PharmaSeq laser light-activated microtransponder, also known as "p-Chip". The chip's major advantages are its small size (500 ¿m x 500 ¿m x 100 ¿m), unitary design, inertness, ease of use and very low cost. The system consists of the p-Chip-tagged glass slides and tissue cassettes, a stationary reader, a portable reader for trays with slides, and associated software that allows integration with common database software. The main goals of the project are to: 1) develop semi-automated methods of attaching p-Chips to slides and cassettes, 2) build advanced prototypes of the ID reader (wand) and improve key features, such as the form factors for reading each type of container, 3) improve the design of the p-Chip to increase the read range and refine methods of their post-fabrication processing, and 4) conduct extensive pilot test studies with outside collaborators to validate the system. The ID readers will have a modified optical system and will feature wireless communication between the reader and a workstation or central computer. The adoption of the system will improve reliability for tagging and tracking tissue samples.

描述（由申请人提供）：本项目的目的是开发和验证超小型RFID芯片的使用，以标记和跟踪组织病理学实验室中使用的组织盒和载玻片。该系统基于PharmaSeq激光激活微应答器，也称为“p-Chip”。该芯片的主要优点是体积小（500 m x 500 m x 100 m），整体设计，惰性，易于使用和成本非常低。该系统由p-Chip标记的载玻片和组织盒、固定式读取器、载玻片托盘的便携式读取器以及允许与通用数据库软件集成的相关软件组成。该项目的主要目标是：1）开发将p-芯片附接到载玻片和盒的半自动化方法，2）构建ID读取器（棒）的先进原型并改进关键特征，诸如用于阅读每种类型的容器的形状因素，3）改进p-芯片的设计以增加读取范围并改进其制造后处理的方法，以及4）与外部合作者进行广泛的试点测试研究，以验证系统。ID阅读器将具有改进的光学系统，并将在阅读器和工作站或中央计算机之间进行无线通信。该系统的采用将提高标记和跟踪组织样本的可靠性。