Light-activated Electronic p-Chips for Tagging Samples in Biorepositories and Cry

用于标记生物样本库和 Cry 中样本的光激活电子 p 芯片

• 批准号: 8312866
• 负责人: WLODEK MANDECKI
• 金额: $ 30万
• 依托单位: PHARMASEQ, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-20 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8312866
• 关键词: Adhesions; Adhesives; Bar Codes; Biological; Biomedical Research; Cells; Communities; Computer software; Contracts; Crying; Databases; Devices; Electronics; Evaluation; Failure; Feedback; Freezing; Goals; Human Resources; Ice; Institution; Label; Laboratories; Lasers; Light; Link; Liquid substance; Manufacturer Name; Medical Research; Methodology; Methods; Nitrogen; Optics; Performance; Phase; Play; Positioning Attribute; Procedures; Process; Protocols documentation; Reader; Reading; Research Personnel; Role; Sampling; Silicon; Silicon Dioxide; Site; Solutions; Surface; System; Techniques; Technology; Temperature; Testing; Time; Tissues; Tube; Validation; Vial device; Work; Writing; base; biobank; biological research; cold temperature; comparative; cost; cost effective; design; design and construction; digital; extreme temperature; improved; operation; prototype; software development; validation studies

DESCRIPTION (provided by applicant): The purpose of the present project is to implement a new RFID tagging system for rapid identification of vials in biorepositories. It is based on the PharmaSeq laser light- activated microtransponder, which is also known as a p-Chip. Its main advantages are its small size, low cost, inertness (silica-based), and durability under extremes of temperature. P-Chips have been shown to be viable and easy to read under conditions, such as the presence of frost, where traditional bar code labels fail due to problems related to interference or adhesive failure. Determining the serial ID numbers of p-Chips imbedded in the walls of vials is done with a dedicated reader that can be configured in several ways. The software associates a particular vial ID with a database to determine the provenance of the sample. Reading is extremely rapid giving the opportunity to maintain (or be close to) the storage temperature during polling. The main goals of this project are to: (1) design and optimize the process for embedding p-Chips in one or more types of sample vials for use at varying storage temperatures; (2) modify the existing p-Chip/reader system for use with vials, including designing and implementing bench-top readers that can either poll single vials or entire racks of vials; (3) improve key features of the p-Chips themselves for very low temperature conditions; (4) provide software routines that are compatible with existing enterprise systems for biorepositories; and (5) to validate the system with several collaborators. Successful completion of this work will result in a method and standard operating procedures that will improve sample storage techniques and provide more reliable samples to the biomedical research community. PUBLIC HEALTH RELEVANCE: Biorepositories play an important role in basic and applied biological and medical research. A key issue for many researchers is the availability of high quality tissue, cell, and other types of samples whose identify is well characterized, and not compromised. The new electronic identification system has the potential to greatly increase the use of RFID technology in sample storage and to help to maintain sample identity and integrity.

描述（由申请人提供）：本项目的目的是实施一种新的RFID标签系统，用于快速识别生物储存库中的小瓶。它基于PharmaSeq激光激活微应答器，也称为p芯片。它的主要优点是体积小、成本低、惰性（硅基）和在极端温度下的耐用性。P-Chip已经被证明是可行的，并且在诸如霜的存在的条件下易于读取，其中传统的条形码标签由于与干扰或粘合剂失效相关的问题而失效。确定嵌入小瓶壁中的p芯片的序列ID号是使用可以以多种方式配置的专用读取器完成的。该软件将特定的小瓶ID与数据库相关联，以确定样品的来源。阅读非常迅速，从而有机会在轮询期间保持（或接近）存储温度。该项目的主要目标是：（1）设计和优化将p-芯片嵌入一种或多种类型的样品小瓶中的过程，以在不同的储存温度下使用;（2）修改现有的p-芯片/读取器系统，以用于小瓶，包括设计和实现可以轮询单个小瓶或整个小瓶架的台式读取器;（3）改进p芯片本身在极低温度条件下的关键特性;（4）提供与现有生物储存库企业系统兼容的软件例程;以及（5）与几个合作者一起验证系统。这项工作的成功完成将产生一种方法和标准操作程序，将改善样品储存技术，并为生物医学研究界提供更可靠的样品。 公共卫生相关性：生物储存库在基础和应用生物学和医学研究中发挥着重要作用。对于许多研究人员来说，一个关键问题是高质量的组织、细胞和其他类型的样本的可用性，这些样本的识别特征得到了很好的表征，并且没有受到损害。新的电子识别系统有可能大大增加RFID技术在样品储存中的使用，并有助于保持样品的身份和完整性。