Light-activated Electronic p-Chips for Tagging Samples in Biorepositories and Cry

描述(由申请人提供)：本项目的目的是实现一种新的RFID标签系统，用于快速识别生物仓库中的瓶子。它基于PharmaSeq激光光控微应答器，也被称为p-Chip。它的主要优点是体积小、成本低、惰性(硅基)和在极端温度下的耐用性。P芯片已经被证明在诸如霜冻的条件下是可行的和易于阅读的，在这种情况下，传统的条形码标签由于与干扰或粘合故障相关的问题而失效。确定嵌入瓶壁中的P芯片的序列号是通过专用读取器来完成的，该读取器可以以多种方式配置。该软件将特定的小瓶ID与数据库相关联，以确定样本的来源。读取速度极快，因此有机会在轮询期间保持(或接近)存储温度。该项目的主要目标是：(1)设计和优化将p芯片嵌入一种或多种类型的样品瓶中的工艺，以便在不同的储存温度下使用；(2)修改现有的p-Chip/读取器系统以用于瓶，包括设计和实施能够轮询单个瓶或整架瓶的台式读取器；(3)改进p-芯片本身的主要功能，以适应极低的温度条件；(4)提供与现有企业生物库系统兼容的软件例程；以及(5)与几个合作者一起验证系统。这项工作的成功完成将产生一种方法和标准操作程序，将改进样品存储技术，并向生物医学研究界提供更可靠的样品。

DESCRIPTION (provided by applicant): The purpose of the present project is to implement a new RFID tagging system for rapid identification of vials in biorepositories. It is based on the PharmaSeq laser light- activated microtransponder, which is also known as a p-Chip. Its main advantages are its small size, low cost, inertness (silica-based), and durability under extremes of temperature. P-Chips have been shown to be viable and easy to read under conditions, such as the presence of frost, where traditional bar code labels fail due to problems related to interference or adhesive failure. Determining the serial ID numbers of p-Chips imbedded in the walls of vials is done with a dedicated reader that can be configured in several ways. The software associates a particular vial ID with a database to determine the provenance of the sample. Reading is extremely rapid giving the opportunity to maintain (or be close to) the storage temperature during polling. The main goals of this project are to: (1) design and optimize the process for embedding p-Chips in one or more types of sample vials for use at varying storage temperatures; (2) modify the existing p-Chip/reader system for use with vials, including designing and implementing bench-top readers that can either poll single vials or entire racks of vials; (3) improve key features of the p-Chips themselves for very low temperature conditions; (4) provide software routines that are compatible with existing enterprise systems for biorepositories; and (5) to validate the system with several collaborators. Successful completion of this work will result in a method and standard operating procedures that will improve sample storage techniques and provide more reliable samples to the biomedical research community.