Light-activated Electronic p-Chips for Tagging Samples in Biorepositories and Cry

描述（由申请人提供）：本项目的目的是实施一种新的RFID标签系统，用于快速识别生物储存库中的小瓶。它是基于PharmaSeq激光激活微应答器，也被称为p-Chip。它的主要优点是体积小、成本低、惰性（硅基）和极端温度下的耐久性。P-Chips已被证明是可行的，并且易于在条件下读取，例如存在霜冻，传统条形码标签由于与干扰或粘合剂失效相关的问题而失效。确定嵌入在小瓶壁上的p芯片的序列号是用专用的读取器完成的，可以通过几种方式配置。该软件将特定的小瓶ID与数据库相关联，以确定样品的来源。读取速度非常快，从而有机会在轮询期间保持（或接近）存储温度。该项目的主要目标是：(1)设计和优化将p-Chips嵌入一种或多种样品瓶中的工艺，以在不同的储存温度下使用；(2)修改现有的p-Chip/读取器系统以用于小瓶，包括设计和实现可以轮询单个小瓶或整个小瓶的台式读取器；(3)在极低温条件下改进p-Chips本身的关键特性；（四）提供与现有生物库企业系统兼容的软件程序；(5)与多个合作者验证系统。这项工作的成功完成将产生一种方法和标准操作程序，这将改进样品储存技术，并为生物医学研究界提供更可靠的样品。

DESCRIPTION (provided by applicant): The purpose of the present project is to implement a new RFID tagging system for rapid identification of vials in biorepositories. It is based on the PharmaSeq laser light- activated microtransponder, which is also known as a p-Chip. Its main advantages are its small size, low cost, inertness (silica-based), and durability under extremes of temperature. P-Chips have been shown to be viable and easy to read under conditions, such as the presence of frost, where traditional bar code labels fail due to problems related to interference or adhesive failure. Determining the serial ID numbers of p-Chips imbedded in the walls of vials is done with a dedicated reader that can be configured in several ways. The software associates a particular vial ID with a database to determine the provenance of the sample. Reading is extremely rapid giving the opportunity to maintain (or be close to) the storage temperature during polling. The main goals of this project are to: (1) design and optimize the process for embedding p-Chips in one or more types of sample vials for use at varying storage temperatures; (2) modify the existing p-Chip/reader system for use with vials, including designing and implementing bench-top readers that can either poll single vials or entire racks of vials; (3) improve key features of the p-Chips themselves for very low temperature conditions; (4) provide software routines that are compatible with existing enterprise systems for biorepositories; and (5) to validate the system with several collaborators. Successful completion of this work will result in a method and standard operating procedures that will improve sample storage techniques and provide more reliable samples to the biomedical research community.