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Animal care: supporting research on autoimmune, inflammatory and muscle diseases

动物护理：支持自身免疫、炎症和肌肉疾病的研究

基本信息

批准号：
8940198
负责人：
Massimo Gadina
金额：
$ 170.81万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8940198
关键词：
Accreditation Adult Affect Allergic rhinitis Ambulatory Care Animal Care and Use Committees Animal Diseases Animal Housing Animals Apoptosis Area Arthritis Autoimmune Process Autoimmunity Bone Development Bone Marrow Transplantation Bone Regeneration Cartilage Chondrogenesis Cytoskeleton Degenerative polyarthritis Disease Ensure Equipment and supply inventories Exclusion Familial Mediterranean Fever Fostering Genes Genetic Recombination Glycogen storage disease type II Guidelines Hypersensitivity In Vitro Inflammatory Institutes International Laboratory Animals Modeling Mus Muscle Muscle Development Myofibrils Myositis National Institute of Arthritis and Musculoskeletal and Skin Diseases Organelles Process Proteins Rattus Regulation Research Research Personnel Research Support Sentinel Site Visit Skeletal Muscle Skin Skin Tissue Syndrome Tissue Engineering Transgenic Mice Tumor Necrosis Factor Receptor United States National Institutes of Health Voting Work animal care animal facility chromatin remodeling expectation fetal meetings member programs receptor research facility research study response retroviral transduction

项目摘要

The LACU assists the NIAMS IRP investigators with their research involving animals. NIAMS animals housed in animal facilities located on the NIH campus, including the NIAMS LACU facility located in Building 10, room 9C127 (the Ambulatory Care Research Facility (ACRF)), as well as in Buildings 6B, 10A, 50 and Building 14. NIAMS animal users work primarily with mice and rats. The NIAMS IRP Animal Program has oversight for 20 Animal Study Proposals (ASPs) using mouse and rat models. The LACU assists researchers with preparing ASPs and has 3 members (1 alternate and 2 voting) on the NIAMS Animal Care and Use Committee (ACUC). The LACU maintains current detailed animal inventory, the foster colony and the sentinel program for the IRP animals. IRP project areas include arthritis, allergic rhinitis and other transmit receptor-induced cellular responses, recombination/chromatin remodeling using AID transgenic mice, familial Mediterranean fever (FMF), and TNF receptor associated periodic syndrome. Research involves muscle and related diseases (experimentation with: N-RAP protein, glycogen storage disease Type II, SIRT1 gene, myofibril assembly, and myositis) and sub-cellular organelles and cytoskeleton in skeletal muscle, as well as in vitro experiments examining retroviral transduction, bone marrow transplantation, and epidermal differentiation using fetal and adult skin tissues. Many of the institutes studies involve apoptosis and autoimmunity, as well as cartilage studies focused on tissue-engineered cartilage, chondrogenesis, GDF-F, COMP and osteoarthritis. The 10/9C127 Animal Facility prepared for and participated in the successful NIH wide 2014 AAALAC site visit.

LACU协助NIAMS IRP研究人员进行涉及动物的研究。NIAMS动物圈养在NIH园区的动物设施中，包括位于10号楼9 C127室的NIAMS LACU设施（门诊护理研究设施（ACRF））以及6 B、10A、50号楼和14号楼。NIAMS动物用户主要使用小鼠和大鼠。 NIAMS IRP动物项目监督了20项使用小鼠和大鼠模型的动物研究提案（ASP）。LACU协助研究人员准备ASP，在NIAMS动物护理和使用委员会（ACUC）有3名成员（1名候补和2名投票）。LACU维护IRP动物的当前详细动物清单、寄养群和哨兵计划。IRP项目领域包括关节炎、过敏性鼻炎和其他传递受体诱导的细胞反应、使用AID转基因小鼠的重组/染色质重塑、家族性地中海热（FMF）和TNF受体相关的周期性综合征。研究涉及肌肉和相关疾病（实验：N-RAP蛋白，糖原累积病II型，SIRT 1基因，肌原纤维组装和肌炎）和亚细胞器和骨骼肌中的细胞骨架，以及体外实验检查逆转录病毒转导，骨髓移植和使用胎儿和成人皮肤组织的表皮分化。该研究所的许多研究涉及细胞凋亡和自身免疫，以及软骨研究，重点是组织工程软骨，软骨形成，GDF-F，COMP和骨关节炎。 10/9 C127动物机构准备并参与了成功的NIH范围内的2014 AAALAC研究中心访问。