Animal care: supporting research on pathogenesis and treatment of autoimmunity

动物护理：支持自身免疫发病机制和治疗的研究

• 批准号: 7970351
• 负责人: Massimo Gadina
• 金额: $ 104.79万
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7970351
• 关键词: Accreditation; Adult; Affect; Allergic rhinitis; Animal Care and Use Committees; Animal Diseases; Animal Housing; Animals; Apoptosis; Arthritis; Autoimmunity; Bone Development; Bone Marrow Transplantation; Cartilage; Chondrogenesis; Complex; Cytoskeleton; Degenerative polyarthritis; Disease; Ensure; Exclusion; Familial Mediterranean Fever; Fishes; Genes; Genetic Recombination; Glycogen storage disease type II; Guidelines; Hypersensitivity; In Vitro; Inflammatory; Institutes; International; Laboratory Animals; Modeling; Mus; Muscle; Muscle Development; Myofibrils; Myositis; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Organelles; Oryctolagus cuniculus; Pathogenesis; Pharmaceutical Preparations; Process; Program Reviews; Proteins; Rattus; Regulation; Research; Research Personnel; Research Support; Sentinel; Skeletal Muscle; Skin; Skin Tissue; Syndrome; Tissue Engineering; Transgenic Mice; United States National Institutes of Health; Voice; Voting; Work; animal care; animal facility; chromatin remodeling; expectation; fetal; meetings; member; programs; receptor; repaired; research study; response; retroviral transduction

The LACU assists the NIAMS IRP investigators with their research involving animals. Such animals are housed in shared animal facilities on the NIH campus including the NIAMS LACU directly overseen facility located in Building 10 in 9/C127 in the ACRF Buildings 6B, 10A, 50 and the Building 14 complex. NIAMS animal users work primarily with mice, but may also use rats, rabbits and fish. The NIAMS IRP Animal Program has oversight for 25 Animal Study Proposals (ASPs) using mouse, rat, fish, and rabbit models. The LACU assists researchers prepare ASPs and has 3 voting members and 1 alternate on the NIAMS Animal Care and Use Committee (ACUC). It also maintains the sentinel IRP projects include arthritis, allergic rhinitis and other transmit receptor-induced cellular responses, recombination/chromatin remodeling using AID transgenic mice, familial Mediterranean fever (FMF), Tnf receptor associated periodic syndrome. Research involves muscle and related diseases (experimentation with: N-RAP protein, glycogen storage disease Type II, SIRT1 gene, myofibril assembly, myositis including drug induced, and the voice generating muscle in Midshipman fish) and sub-cellular organelles and cytoskeleton in skeletal muscle as well as in vitro experiments examining retroviral transduction, bone marrow transplantation, and epidermal differentiation using fetal and adult skin tissues. Many of the institutes studies involve apoptosis and autoimmunity, as well as cartilage studies focused on tissue-engineered cartilage, chondrogenesis, GDF-F, COMP and osteoarthritis. The NIAMS IRP LACU facilitated the accreditation of NIH with the Association for the Assessment and Accreditation of Laboratory Animal Care International (AALACi) during the program review and inspection in 2007 and is working to maintain the accreditation after the next inspection.

LACU协助NIAMS IRP研究人员进行涉及动物的研究。这些动物饲养在NIH园区的共享动物设施中，包括位于ACRF 6 B、10A、50号楼9/C127 10号楼和14号楼综合体的NIAMS LACU直接监督设施。NIAMS动物用户主要使用小鼠，但也可能使用大鼠，兔子和鱼。 NIAMS IRP动物项目监督了使用小鼠、大鼠、鱼和兔模型的25项动物研究提案（ASP）。LACU协助研究人员准备ASP，并在NIAMS动物护理和使用委员会（ACUC）中拥有3名投票成员和1名候补成员。 它还保持了哨兵IRP项目包括关节炎，过敏性鼻炎和其他传递受体诱导的细胞反应，重组/染色质重塑使用AID转基因小鼠，家族性地中海热（FMF），TNF受体相关的周期性综合征。研究涉及肌肉和相关疾病（实验：N-RAP蛋白，糖原累积病II型，SIRT 1基因，肌原纤维组装，肌炎，包括药物诱导，和声音产生肌肉在海军军官鱼）和亚细胞器和骨骼肌细胞骨架以及体外实验检查逆转录病毒转导，骨髓移植，表皮分化使用胎儿和成人皮肤组织。该研究所的许多研究涉及细胞凋亡和自身免疫，以及软骨研究，重点是组织工程软骨，软骨形成，GDF-F，COMP和骨关节炎。NIAMS IRP LACU在2007年的项目审查和检查期间促进了NIH与国际实验动物评估和认证协会（AALACi）的认证，并正在努力在下次检查后保持认证。