Animal care: supporting research on autoimmune, inflammatory and muscle diseases

动物护理:支持自身免疫、炎症和肌肉疾病的研究

基本信息

项目摘要

The LACU assists the NIAMS IRP investigators with their research involving animals. NIAMS animals are housed in animal facilities located on the NIH campus, including the NIAMS LACU facility located in Building 10, room 9C127 (the Ambulatory Care Research Facility (ACRF)), as well as in Buildings 6B, 10A, 50 and Building 14. NIAMS animal users work primarily with mice and rats. The NIAMS IRP Animal Program has oversight for 24 Animal Study Proposals (ASPs) using mouse and rat models. The LACU assists researchers with preparing ASPs through a thorough peer-review process and has 3 members (2 voting and 1 alternate) on the NIAMS Animal Care and Use Committee (ACUC). The LACU maintains a close to real time and detailed animal inventory, the foster colony, a large breeding colony, and the sentinel program for the IRP animals. An approximately 1-hour training program, administered by the LACU colony manager, familiarizes all new NIAMS investigators and PIs with NIH and NIAMS-specific guidelines, a general overview of rodent colony management, and rodent biology as it relates to breeding and research guidelines. IRP project areas include arthritis, allergic rhinitis and other receptor-induced cellular responses, recombination/chromatin remodeling using AID transgenic mice, familial Mediterranean fever (FMF), and TNF receptor-associated periodic syndrome. Research involves muscle and related diseases (experimentation with N-RAP protein, glycogen storage disease Type II, SIRT1 gene, myofibril assembly, and myositis) and sub-cellular organelles and cytoskeleton in skeletal muscle, as well as in vitro experiments examining retroviral transduction, bone marrow transplantation, and epidermal differentiation using fetal and adult skin tissues. Many of the institutes studies involve apoptosis and autoimmunity, as well as cartilage studies focused on tissue-engineered cartilage, chondrogenesis, GDF-F, COMP and osteoarthritis. The NIAMS program continues to meet all accreditation requirements set forth by Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC), and is preparing for the next NIH-wide visit in June of 2021.
LACU协助NIAMS IRP研究人员进行涉及动物的研究。NIAMS的动物被安置在NIH校园内的动物设施中,包括位于10号楼9C127室(流动护理研究设施(ACRF))的NIAMS LACU设施,以及6B、10A、50和14号楼。NIAMS的动物使用者主要使用小鼠和大鼠。

项目成果

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Massimo Gadina其他文献

Massimo Gadina的其他文献

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{{ truncateString('Massimo Gadina', 18)}}的其他基金

High Throughput Next Generation Sequencing: supports genomics and epigenomics research in muscle, skin, bone and autoimmune diseases.
高通量下一代测序:支持肌肉、皮肤、骨骼和自身免疫性疾病的基因组学和表观基因组学研究。
  • 批准号:
    10496410
  • 财政年份:
  • 资助金额:
    $ 158.1万
  • 项目类别:
Translational Immunology research: a support for clinical immunological research
转化免疫学研究:临床免疫学研究的支持
  • 批准号:
    8344974
  • 财政年份:
  • 资助金额:
    $ 158.1万
  • 项目类别:
Animal care: supporting research on pathogenesis and treatment of autoimmunity
动物护理:支持自身免疫发病机制和治疗的研究
  • 批准号:
    8345004
  • 财政年份:
  • 资助金额:
    $ 158.1万
  • 项目类别:
Animal care: supporting research on autoimmune, inflammatory and muscle diseases
动物护理:支持自身免疫、炎症和肌肉疾病的研究
  • 批准号:
    8940198
  • 财政年份:
  • 资助金额:
    $ 158.1万
  • 项目类别:
Applying Bioinformatics to Research in Immune, Muscle, and Bone Diseases
将生物信息学应用于免疫、肌肉和骨骼疾病的研究
  • 批准号:
    8940203
  • 财政年份:
  • 资助金额:
    $ 158.1万
  • 项目类别:
Flow cytometry support to research in immune, skin, muscle and bone diseases
流式细胞术支持免疫、皮肤、肌肉和骨骼疾病的研究
  • 批准号:
    9563188
  • 财政年份:
  • 资助金额:
    $ 158.1万
  • 项目类别:
Animal care: supporting research on pathogenesis and treatment of autoimmunity
动物护理:支持自身免疫发病机制和治疗的研究
  • 批准号:
    7970351
  • 财政年份:
  • 资助金额:
    $ 158.1万
  • 项目类别:
Applying Bioinformatics to Research in Immune, Muscle, and Bone Diseases
将生物信息学应用于免疫、肌肉和骨骼疾病的研究
  • 批准号:
    7732838
  • 财政年份:
  • 资助金额:
    $ 158.1万
  • 项目类别:
Animal care: supporting research on pathogenesis and treatment of autoimmunity
动物护理:支持自身免疫发病机制和治疗的研究
  • 批准号:
    8158460
  • 财政年份:
  • 资助金额:
    $ 158.1万
  • 项目类别:
Flow cytometry support to research in immune, skin, muscle and bone diseases
流式细胞术支持免疫、皮肤、肌肉和骨骼疾病的研究
  • 批准号:
    10697886
  • 财政年份:
  • 资助金额:
    $ 158.1万
  • 项目类别:

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