Integrating drug delivery principles into drug design to transform the treatment of immune disease

将药物输送原理融入药物设计以改变免疫疾病的治疗

• 批准号: nhmrc : 1009212
• 负责人: A/Pr Frank Alderuccio
• 金额: $ 36.85万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/integrating-drug-delivery-immune-disease/109384
• 关键词: Integrating; drug; delivery; principles; into

Immune system disorders (e.g. rheumatoid arthritis, transplant rejection, Crohn’s disease, multiple sclerosis) are often treated with immunosuppresant drugs. However, immunosuppressant drugs can cause significant toxicity and can lack efficacy. This proposal will show how the design of drugs used to treat immune disorders can be changed to allow drugs to be delivered specifically to their site of action (immune cells) thereby enhancing activity and reducing toxicity.

免疫系统疾病（例如类风湿性关节炎、移植排斥、克罗恩病、多发性硬化）通常用免疫抑制药物治疗。然而，免疫抑制剂药物可引起显著的毒性并且可缺乏功效。该提案将展示如何改变用于治疗免疫疾病的药物的设计，以允许药物特异性地递送到其作用部位（免疫细胞），从而增强活性并降低毒性。