Stem cell engineering to establish tolerance and reverse autoimmunity

干细胞工程建立耐受性并逆转自身免疫

• 批准号: nhmrc : 284260
• 负责人: A/Pr Frank Alderuccio
• 金额: $ 33.16万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stem-cell-engineering-reverse-autoimmunity/76447
• 关键词: Stem; cell; engineering; establish; tolerance

The immune system is designed to protect us from harmful invaders such as bacteria, viruses and parasites. It should not attack our own tissues. However, in certain individuals, the immune system does attack our own tissues leading to life threatening conditions such as diabetes, multiple sclerosis and rheumatoid arthritis. To date, there is no cure for autoimmune diseases. Treatment is designed to treat the destructive effects of the disease. A strategy for achieving a cure is to program the immune system to remove the harmful immune cells. Autoimmune gastritis which leads to pernicious anaemia is an autoimmune disease which affects the acid secreting cells of the stomach. To get a better understanding of autoimmune diseases, animal models are often used. We use a number of mouse models of autoimmune gastritis which closely resembles the human disease and thus makes a very good working model. Using these models we are exploring novel techniques aimed at reversing or curing established disease. This relies on removing the disease causing cells from the body and re-programming the immune system so as not to produce these cells.

免疫系统旨在保护我们免受细菌，病毒和寄生虫等有害入侵者的侵害。它不应该攻击我们自己的组织。然而，在某些个体中，免疫系统确实会攻击我们自己的组织，导致危及生命的疾病，如糖尿病，多发性硬化症和类风湿性关节炎。到目前为止，还没有治愈自身免疫性疾病的方法。治疗旨在治疗疾病的破坏性影响。实现治愈的一个策略是编程免疫系统以去除有害的免疫细胞。导致恶性贫血的自身免疫性胃炎是一种影响胃泌酸细胞的自身免疫性疾病。为了更好地了解自身免疫性疾病，经常使用动物模型。我们使用了许多小鼠自身免疫性胃炎模型，这些模型与人类疾病非常相似，因此是一个非常好的工作模型。利用这些模型，我们正在探索旨在逆转或治愈已建立疾病的新技术。这依赖于从身体中去除致病细胞并重新编程免疫系统，以便不产生这些细胞。