The role of Aire in immunological tolerance and autoimmunity

Aire 在免疫耐受和自身免疫中的作用

• 批准号: nhmrc : 491004
• 负责人: A/Pr Frank Alderuccio
• 金额: $ 28.95万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-aire-immunological-tolerance-autoimmunity/95649
• 关键词: role; Aire; immunological; tolerance; autoimmunity

The immune system is designed to protect us from foreign pathogens such as bacteria, viruses and parasites. This is achieved through lymphocytes which recognise foreign pathogens. However in 5-6% of the population the immune system attacks the host and induces autoimmunity. We aim to understand the mechanisms which control the production of self-reacting lymphocytes and how we may reduce the incidence of autoimmunity.

免疫系统旨在保护我们免受细菌，病毒和寄生虫等外来病原体的侵害。这是通过识别外来病原体的淋巴细胞实现的。然而，在5-6%的人群中，免疫系统会攻击宿主并诱导自身免疫。我们的目标是了解控制自身反应淋巴细胞产生的机制，以及如何降低自身免疫的发生率。