Mentoring Junior Faculty in Alcoholic Liver Disease

描述(由申请者提供)：这个高级科学家研究和导师奖的目标是促进在酒精性肝损伤和纤维化领域具有特殊潜力的独立研究人员的初级教员(助理教授)的职业生涯。作为NIH资助的研究人员，PI有25年的经验，并指导了50多名学员，其中许多人现在凭借自己的能力成为学术肝病和肝脏研究领域的领导者。他在了解肝纤维化和癌症发病机制方面的长期成就帮助催生了一门令人兴奋的新学科，继续吸引有才华的初级医学、博士和医学/博士科学家来到他的实验室。他的实验室和他在西奈山医学院肝病科的学生的研究与最近授予NIAAA P20基金的研究相结合，重点是酒精性肝损伤和纤维化。这些年轻的研究人员开展的协同工作通过利用包括斑马鱼、胚胎干细胞、遗传小鼠模型和肝细胞共培养在内的新模型来探索肝脏损伤和炎症的基础。他们的工作将促进我们对氧化应激、转录基因调控、树突状细胞生物学以及病毒感染在酒精性肝损伤和纤维化发病机制中的影响的理解。此外，受训者在PI的总体指导下进行的相互交织的项目将跨越从基础细胞和分子生物学到人体组织分析的全翻译范围，并最终可能转化为酒精引起的慢性肝病患者的新诊断和治疗方法。预计该奖项支持的指导关系将培养出一支训练有素的年轻教员队伍，能够推动酒精研究领域的发展，他们很可能成为该领域的下一代领导者。

DESCRIPTION (provided by applicant): The goal of this Senior Scientist Research and Mentorship Award is to foster the careers of junior faculty (Assistant Professors) who have exceptional potential as independent investigators in the field of alcoholic liver injury and fibrosis. The PI has 25 years experience as an NIH funded investigator and has mentored over 50 trainees, many of whom are now leaders in their own right in the field of academic hepatology and liver research. His longstanding record of accomplishment in understanding the pathogenesis of hepatic fibrosis and cancer has helped spawn an exciting new discipline that continues to attract talented junior MD, PhD, and MD/PhD scientists to his laboratory. Studies in his laboratory and those of his mentees in the Division of Liver Diseases of the Mount Sinai School of Medicine have coalesced with the recent award of a NIAAA P20 grant focused on alcoholic liver injury and fibrosis. The synergistic efforts conducted by these young investigators explore the basis of hepatic injury and inflammation by exploiting novel models that include zebrafish, embryonic stem cells, genetic mouse models, and liver cell co-cultures. Their work will advance our understanding of oxidant stress, transcriptional gene regulation, dendritic cell biology and the impact of viral infection on the pathogenesis of alcoholic liver injury and fibrosis. Moreover, the interwoven projects undertaken by the mentees, under the overarching guidance of the PI, will span the full translational spectrum from fundamental cell and molecular biology to analysis of human tissues, and ultimately could translate into novel diagnostics and therapeutics for patients with chronic liver disease due to alcohol. It is anticipated that the mentoring relationships supported by this award will yield a cadre of highly trained young faculty capable of advancing the field of alcohol research, and who will likely emerge among the next generation of leaders in the field.