International Symposium on Alcoholic Liver and Pancreatic Disease (ALPD)

描述(由申请人提供)：本R13申请寻求支持将在埃及赫尔加达举行的第四届酒精性肝和胰腺疾病(ALPD)和肝硬变国际研讨会。前三届研讨会非常成功，产生了丰富的新合作，导致了该领域的重大进展，我们完全预计这一计划将产生类似的协同效应。这次会议将由埃及卫生部和开罗大学共同主办。主题包括肝纤维化、肝和胰腺坏死、细胞凋亡和再生的机制、ALPD治疗的新研究、酒精和丙型肝炎病毒导致肝损伤和肝硬化的相互作用。此外，我们还将举办四场由肝脏和胰腺疾病领域的权威人士主讲的专题讲座。目标受众既有成熟的和初级的调查人员，也有来自世界各地，特别是中东和非洲的在ALPD领域工作的研究生和博士后研究员。这次会议的总体目标是：1)促进不同遗传和社会背景的不同人群患有酒精性肝和胰腺疾病的不同国家之间的国际合作；2)共享各国现有的资源，从而增加协同作用和独特的想法；以及3)鼓励年轻的研究人员在国际层面上进行互动。通过吸收来自学科外的演讲者以及使用酒精性肝病新模型的演讲者，我们相信这次会议将为科学增长和合作创造独特的机会，最终推动该领域的发展。主办方将在会议结束后立即编写书面摘要材料，提交给同行评议的期刊，以便尽可能广泛地传播会议内容。 公共卫生相关性：本申请寻求支持组织第四届酒精性肝脏、胰腺疾病和肝硬变国际研讨会，将对酒精对肝脏和胰腺的损害感兴趣的科学家聚集在一起。通过为来自多个学科的专家提供一个论坛，讨论与酗酒有关的问题并分享他们的最新数据，该领域可能会出现新的科学问题和新的方向。最终，这些将导致科学突破，定义这些由酒精引起的严重疾病的新治疗方法。

DESCRIPTION (provided by applicant): This R13 application seeks support for the Fourth International Symposium on Alcoholic Liver and Pancreatic Disease (ALPD) and Cirrhosis that will be held in Hurghada, Egypt. The prior three Symposia were highly successful and generated a wealth of new collaborations that led to major advances in the field, and we fully anticipate that this program will have a similar, synergizing effect. This meeting will be co-hosted by the Egyptian Ministry of Health and Cairo University. Topics will include mechanisms of liver fibrosis, hepatic and pancreatic necrosis, apoptosis and regeneration, novel research on treatment of ALPD, interactions of alcohol and hepatitis C virus resulting in liver damage and cirrhosis. In addition, we will have four special lectures to be delivered by authorities in the field of liver and pancreatic diseases. The target audience is both established and junior investigators, as well as graduate students and post-doctoral fellows who work in the field of ALPD from all over the world, especially the Middle East and Africa. The overall aims of this meeting are to: 1) promote international collaboration between different countries with different populations of diverse genetic and social background who suffer from alcoholic liver and pancreatic diseases; 2) share the resources available in various countries, thus adding synergy and unique ideas together; and 3) encourage young investigators to interact at an international level. By incorporating speakers from outside disciplines, as well as those utilizing novel models of alcoholic liver disease, we are confident that the meeting will create unique opportunities for scientific growth and collaboration, ultimately advancing the field. Written summary materials will be generated by the organizers immediately after the meeting for submission to a peer reviewed journal to disseminate the contents of the meeting as broadly as possible. PUBLIC HEALTH RELEVANCE: This application seeks support for organizing the fourth international Symposium on Alcoholic Liver and Pancreatic Disease and Cirrhosis, to bring together scientists interested in the damaging effects of alcohol on the liver and pancreas. By providing a forum for experts from many disciplines to discuss the problems related to alcohol abuse and share their latest data, new scientific questions and new directions in the field are likely to emerge. Ultimately, these will lead to scientific breakthroughs that will define new treatments for these serious illnesses caused by alcohol.