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Training in the Neurobiology of Neurodegenerative Disease

神经退行性疾病神经生物学培训

基本信息

批准号：
8705079
负责人：
MICHAEL J ZIGMOND
金额：
$ 5.37万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8705079
关键词：
Neurobiology Neurodegenerative Disorders Training

项目摘要

DESCRIPTION (provided by applicant): We request continuing support for our postdoctoral training program in basic neuroscience as it relates to neurodegenerative disease and stroke. The program is closely integrated with several key research programs related to Parkinson's disease, Alzheimer's disease, ALS, and stroke, and to the Pittsburgh Institute for Neurodegenerative Diseases, now housed in contiguous space within a newly constructed state-of-the-art facility. Additional programs in psychiatric disorders and in neuro-AIDS further enhance the environment. The grant will permit us to maintain the critical mass needed to recruit the best possible postdoctoral trainees, including underrepresented minority trainees, and to offer a training program of the highest quality. Our training program focuses primarily on basic and translational laboratory research that can readily be related to neurodegenerative disease and stroke. The major research advisor and an individualized research advisory committee and the training grant steering committee share the task of guiding and monitoring each trainee. All trainees participate in four activities that supplement their research experience: 1) A seminars on the neurobiology of clinical disorders, 2) a monthly research discussion, 3) a series of professional development workshops, and 4) at least one outreach activity. Issues of responsible conduct are integrated into the entire program. Trainees also participate in courses as needed and have opportunities to teach and to observe clinical practice. The 33 members of the training faculty are members of the university-wide program in neuroscience with a particular interest in neurodegenerative disorders and stroke. Most of the faculty members have extensive experience in training and in research and have significant grant support. In addition, we have included a group of 9 junior faculty who have outstanding promise and will be available to serve as co-mentors in conjunction with a more senior faculty member. At present our training faculty supervise more than 90 postdoctoral trainees (in addition to a large number of pre-doctoral students), of whom about 20 are eligible for NRSA support. We are requesting stipends to support an initial complement of 4 postdoctoral trainees, increasing gradually to 6 over a 5-year period. We believe that our training program provides an opportunity for outstanding postdoctoral trainees to prepare for a career of direct relevance to issues of neurodegenerative disease and stroke.

描述（由申请人提供）：我们要求继续支持我们的博士后培训计划在基础神经科学，因为它涉及到神经退行性疾病和中风。该计划与帕金森病，阿尔茨海默病，ALS和中风相关的几个关键研究计划以及匹兹堡神经退行性疾病研究所紧密结合，该研究所现在位于新建的最先进设施内的连续空间内。精神疾病和神经艾滋病方面的其他方案进一步改善了环境。这笔赠款将使我们能够保持必要的临界质量，以招募最好的博士后学员，包括代表性不足的少数民族学员，并提供最高质量的培训计划。我们的培训计划主要集中在基础和转化实验室研究，可以很容易地与神经退行性疾病和中风。主要研究顾问、个性化研究咨询委员会和培训补助金指导委员会共同承担指导和监督每一位受训者的任务。所有学员参加四项活动，以补充他们的研究经验：1）临床疾病的神经生物学研讨会，2）每月研究讨论，3）一系列专业发展研讨会，以及4）至少一次外展活动。负责任的行为问题被纳入整个方案。受训人员还根据需要参加课程，并有机会讲授和观察临床实践。培训教师的33名成员都是大学神经科学计划的成员，对神经退行性疾病和中风特别感兴趣。大多数教师在培训和研究方面拥有丰富的经验，并获得了大量的资助。此外，我们还包括一个由9名初级教师组成的小组，他们具有出色的承诺，并将与一名更高级的教师一起担任共同导师。目前，我们的培训教师监督90多名博士后学员（除了大量的博士前学生），其中约20人有资格获得NRSA的支持。我们正在申请助学金，以支持最初补充4名博士后学员，并在5年内逐步增加到6名。我们相信，我们的培训计划为优秀的博士后学员提供了一个机会，为与神经退行性疾病和中风问题直接相关的职业生涯做好准备。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast.

DOI：
10.1016/j.ab.2007.07.033
发表时间：
2007-11
期刊：
Analytical biochemistry
影响因子：
2.9
作者：
L. J. Sparvero;Sarah Patz;J. Brodsky;C. Coughlan
通讯作者：
L. J. Sparvero;Sarah Patz;J. Brodsky;C. Coughlan

Attention can either increase or decrease spike count correlations in visual cortex.

DOI：
10.1038/nn.3835
发表时间：
2014-11
期刊：
NATURE NEUROSCIENCE
影响因子：
25
作者：
Ruff, Douglas A.;Cohen, Marlene R.
通讯作者：
Cohen, Marlene R.

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy.

DOI：
10.1016/j.nbd.2014.11.015
发表时间：
2015-02
期刊：
NEUROBIOLOGY OF DISEASE
影响因子：
6.1
作者：
Van Laar, Victor S.;Roy, Nikita;Liu, Annie;Rajprohat, Swati;Arnold, Beth;Dukes, April A.;Holbein, Cory D.;Berman, Sarah B.
通讯作者：
Berman, Sarah B.

Extracellular voltage threshold settings can be tuned for optimal encoding of movement and stimulus parameters.

DOI：
10.1088/1741-2560/13/3/036009
发表时间：
2016-06
期刊：
Journal of neural engineering
影响因子：
4
作者：
Oby ER;Perel S;Sadtler PT;Ruff DA;Mischel JL;Montez DF;Cohen MR;Batista AP;Chase SM
通讯作者：
Chase SM

Balanced GABAergic and glutamatergic synapse development in hippocampal neurons.