Developmental Programming, Maternal Obesity and Overnutrition

发育规划、母亲肥胖和营养过剩

• 批准号: 8598950
• 负责人: PETER W. NATHANIELSZ
• 金额: $ 54.88万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8598950
• 关键词: Address; Adult; Advertising; Advisory Committees; Age; Animals; Area; Australia; Biomedical Research; Biopsy; Birth; Blood; Body Composition; Canada; Carbohydrates; Chronic; Collaborations; Communities; Congresses; Data; Development; Diabetes Mellitus; Diagnostic; Diet; Dietary Intervention; Disease; Eating; England; Environment; Epidemiology; Experimental Designs; Fatty acid glycerol esters; Female; Fetus; Foundations; Funding; Future; Genes; Goals; Health; Health Sciences; Heart Diseases; Human; Human Resources; Hypertension; India; Individual; Institutes; International; Investigation; Lactation; Left; Letters; Life; Measurement; Mental Depression; Modeling; Monitor; Monoclonal Antibody R24; Mothers; National Center for Research Resources; National Children' s Study; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Environmental Health Sciences; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Organism; Outcome; Overnutrition; Papio; Phenotype; Physical activity; Placenta; Predisposition; Pregnancy; Primates; Principal Investigator; Publishing; Records; Reporting; Research; Research Personnel; Resources; Rodent; Rodent Control; Sheep; System; Texas; Therapeutic; Time; Triglycerides; United States National Institutes of Health; Universities; Weaning; Woman; Work; base; cohort; cross reactivity; experience; innovation; interest; male; maternal nutrient restriction; nonhuman primate; nutrition; offspring; programs; public health relevance; response; sex; social group

DESCRIPTION (provided by applicant): Extensive human epidemiological data show that maternal obesity (MO) during development alters offspring (OFF) body composition, predisposing to chronic adult disease (heart disease, obesity, depression, diabetes). Compelling, controlled rodent studies abound but published nonhuman primate (NHP) data on OFF outcomes of MO are unavailable. Approach: We built a unique system to monitor and control individual baboon food intake while maintaining normal group social and physical activity. From nine months before pregnancy randomly selected females of similar phenotype will be maintained either on control (CTR) ad lib diet or a high fat, high carbohydrate, highly palatable diet (HPD) which we developed to produce obesity in young, nulliparous females. MO Females stay on these diets in pregnancy and lactation. OFF eat CTR diet when weaned. Male and female OFF cohorts are characterized to age 3. The Principal Investigator's have been continuously funded by NIH since 1976 for hypothesis driven studies. Preliminary data presented on non-pregnant animals was obtained with Institutional support approaching $100,000. We present examples of studies that can be addressed by ourselves and other investigators who have provided letters. Innovation: To date only one other group studies MO effects on NHP OFF. Their model differs in many ways including individual food intake records and uniformity of pregnancy studied. Environment: In collaboration with the Southwest National Primate Center we have all expertise necessary to investigate female baboons and OFF before, during and after pregnancy. We have received NHLBI, NICHD, NEI, NINCDS, NIA, NIMH, NIDDK and NSF funding for NHP studies and have extensive collaborations. We have established an experienced External Advisory Committee and include letters from 24 investigators who would like to study these OFF. We will also advertise this resource widely. Significance: The $5 billion National Children's Study will follow OFF of 100,000 women to age 18 yrs. Critical information to evaluate developmental programming is difficult to obtain in human pregnancy. NHP studies permit nutritional interventions, repeated biopsies, blood and body measurements of mothers and OFF. Baboons mature faster than humans and can provide timely data to guide the NCS. Well-characterized CTR and obese primiparous mothers on a HPD will deliver OFF for study from birth to old age. This resource will be shared with other investigators in studies relevant to NHLBI, NIDDK, NICHD, NIAID, NEI, NCI, NIA, NINCDS, NIMH, NIEHS and others. The baboon has unique strengths compared to other NHP - single fetus, placenta resembling the human, gene array platform cross- reactivity, established systems for chronic unanaesthetized studies.

描述（由申请人提供）：广泛的人类流行病学数据表明，发育过程中的孕产妇肥胖（MO）改变了后代（OFF）身体组成，易感慢性成人疾病（心脏病，肥胖，肥胖，抑郁症，糖尿病）。引人注目的，受控的啮齿动物研究比比皆是，但不可用的关于MO结果的非人类灵长类动物（NHP）数据是不可用的。方法：我们建立了一个独特的系统来监视和控制单个狒狒食品摄入量，同时保持正常的团体社交和体育锻炼。从妊娠前的九个月开始，随机选择了类似表型的女性，将在对照（CTR）AD LIB饮食或高脂肪，高碳水化合物，高度可口的饮食（HPD）中维持，我们开发出来在年轻的，无效的女性中产生肥胖症。女性在怀孕和泌乳中保持这些饮食。断奶时吃CTR饮食。男性和女性的同类群体的特征是3岁。自1976年以来，首席研究员一直由NIH用于假设驱动的研究。通过机构支持接近100,000美元，获得了非怀孕动物的初步数据。我们介绍了我们自己和其他提供信件的调查人员可以解决的研究示例。创新：迄今为止，仅另一项小组研究对NHP关闭的影响。他们的模型在许多方面有所不同，包括单个食物摄入记录和所研究的妊娠均匀性。环境：与西南国家灵长类动物中心合作，我们拥有对女性狒狒进行调查以及怀孕之前和之后的关闭所需的所有专业知识。我们已经收到了NHLBI，NICHD，NEI，NINCDS，NIA，NIMH，NIDDK和NSF资助，用于NHP研究，并进行了广泛的合作。我们已经成立了一个经验丰富的外部咨询委员会，并包括24位希望研究这些的调查人员的信件。我们还将广告宣传此资源。意义：50亿美元的全国儿童研究将在100,000名妇女到18岁以后。在人类怀孕中，很难获得评估发展节目的关键信息。 NHP研究允许营养干预措施，重复的活检，母亲的血液和身体测量。狒狒比人类成熟的速度快，可以提供及时的数据来指导NCS。特征良好的CTR和HPD上的肥胖的初次母亲将从出生到老年就可以学习。该资源将与其他研究人员共享与NHLBI，NIDDK，NICHD，NIAID，NEI，NCI，NIA，NIA，NICDS，NINCDS，NIMH，NIEHS等相关的研究。与其他NHP相比，狒狒具有独特的优势 - 类似于人类的胎盘，基因阵列平台交叉反应性，已建立的慢性非纳阿纳治疗研究系统。