Collaborative Human Tissue Network

协作人体组织网络

• 批准号: 8669404
• 负责人: WILLIAM E. GRIZZLE
• 金额: $ 74.06万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8669404
• 关键词: Accreditation; Address; Advocate; Affect; African American; Alabama; Aliquot; American; Area; Autopsy; Big Data; Body Fluids; Canada; Caring; Certification; Clinical; Clinical Research; Collaborations; Collection; Complex; Computerized Medical Record; Coupled; DNA; Data; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Doctor of Philosophy; Education; Ensure; Environment; Ethics; Exhibits; Family; Freezing; Fresh Tissue; Funding; Future; Goals; Grant; Guidelines; Health; Healthcare; Hospitals; Human; Image; Individual; Informatics; Information Systems; Information Technology; Institution; Internet; Lead; Leadership; Link; Liquid substance; Malignant Neoplasms; Medical; Medicine; Messenger RNA; Metastatic Lesion; Minority; Modeling; Modification; Needle biopsy procedure; Network-based; Outcome; Paraffin; Participant; Pathologist; Patients; Play; Policies; Primary Neoplasm; Privacy; Procedures; Process; Protocols documentation; Provider; Pyroxylin; Quality Control; Recording of previous events; Research; Research Personnel; Research Support; Resolution; Resources; Retrieval; Role; Sampling; Secure; Site; Social Welfare; Source; Specimen; System; Techniques; Testing; Therapeutic Intervention; Tissue Banks; Tissue Microarray; Tissue Sample; Tissues; Training; Translational Research; United States; Universities; Variant; anticancer research; base; biobank; college; data acquisition; follow-up; human tissue; improved; innovation; interoperability; meetings; neoplastic; novel; novel diagnostics; novel strategies; operation; programs; quality assurance; repository; response; screening; social; success; tissue processing; tumor; tumor registry

DESCRIPTION (provided by applicant): The Collaborative Human Tissue Network is a continuation of a successful program to increase the supply and quality of human tissues to support research in cancer. The University of Alabama at Birmingham (UAB), as the Southern Division (SD) of the CHTN, has participated effectively in all CHTN operations at the national level since 1987. The policies and guidelines that have been established have resulted in a dependable source for cancer researchers of a wide range of expertly processed, well-characterized and high quality human tissues with associated histopathologic and demographic data. New challenges to biorepository operations are emerging, however. The current advances in cancer research, including the issues surrounding research into personalized medicine, have resulted in an increase in demand for tissue samples and more complex requests. Concurrently, changes in medical care, such as preoperative therapy, use of high resolution imaging instead of tissue diagnoses, as well as a changing regulatory environment are affecting tissue collections. The leadership team of the SD has taken a proactive stance to meet the future needs of cancer investigators. (1) Enhancement of operations through recruitment of additional participating sites; increased use of archival paraffin blocks for metastatic lesions and untreated primary tumors; use of novel techniques, including nitrocellulose blots, for obtaining aliquots of small tissue specimens; and development of a rapid autopsy program. These are accompanied by increased education of investigators as to use of alternative tissues (e.g., autopsy, paraffin blocks) and to specimen limitations; (2) Enhancement of quality assurance and quality control through participation in external accreditation processes; and (3) Enhancement of the ethical and regulatory stance through expansion of utilization of patient advocates. The informatics system is critical to all biorepository functions and the SD proposes development of an Investigators' IT system that utilizes new-era interoperability and linked big-data systems. It als proposes an increased emphasis on training and proficiency testing in IT systems, coupled with greater utilization of the Web for access to and training in SOPs. The SD reaffirms its commitment to the operations of the CHTN as a whole. In addition to ongoing involvement at the leadership level, it continues significant collaborative efforts with individual divisions, including supplying tissues for microarrays and beta-testing of modifications of the current IT system. Since 2008, the SD has provided 20,287 fresh, frozen and fixed human aliquots to 264 investigators. Notably, within the CHTN network it provides complex specimens including aliquots of tissue processed within 30 minutes of collection; macrodissected paraffin and frozen tissues and mRNA/DNA samples as well as detailed clinical information and follow-up to investigators. It is one of the leading providers of fresh tissue samples and body fluids and the leading provider of samples from African-American patients.

描述（由申请人提供）：人类组织网络的协作是成功计划，以增加人类组织的供应和质量以支持癌症的研究。自1987年以来，伯明翰（UAB）的阿拉巴马大学作为CHTN的南部分区（SD）有效地参与了国家一级的所有CHTN运营。建立的政策和准则为广泛处理，良好型和高质量的人类组织的癌症研究人员提供了可靠的来源。然而，对生物座席操作的新挑战正在出现。癌症研究的目前进展，包括围绕个性化医学研究的问题，导致对组织样本的需求增加和更复杂的要求。同时，医疗保健的变化，例如术前治疗，使用高分辨率成像而不是组织诊断，以及不断变化的调节环境正在影响组织收集。 SD的领导团队采取了积极的立场，以满足癌症调查人员的未来需求。 （1）通过招募其他参与地点来增强操作；增加用于转移性病变和未经治疗的档案石蜡块的使用增加 原发性肿瘤；使用包括硝酸纤维素印迹在内的新技术来获得小组织标本的等分试样；和开发快速尸检计划。这些伴随着研究人员对使用替代组织的使用（例如尸检，石蜡块）和标本限制的教育。 （2）通过参与外部认证过程来增强质量保证和质量控制； （3）通过扩大患者倡导者利用的利用来增强道德和调控立场。信息系统对于所有生物验证功能至关重要，SD提议开发研究人员的IT系统，该系统利用新时代的互操作性和链接的大数据系统。它提议越来越强调IT系统中的培训和熟练度测试，再加上网络访问和培训SOP的访问和培训的更多利用。 SD重申了其对整个CHTN运营的承诺。除了在领导层进行持续参与外，它还继续与各个部门进行重大合作，包括为微阵列提供组织以及当前IT系统修改的β进行测试。自2008年以来，SD已向264名研究人员提供了20,287个新鲜，冷冻和固定的人类等分试样。值得注意的是，在CHTN网络中，它提供了复杂的标本，包括收集后30分钟内处理的组织的等分试样；宏伟地解剖的石蜡和冷冻组织以及mRNA/DNA样品以及详细的临床信息以及对研究者的随访。它是新鲜组织样品和体液的领先提供者之一，也是非裔美国人患者的领先样品提供者。