DATA MANGEMENT AND STATISTICS CORE

数据库管理和统计核心（DMS）正式确定了自1989年哥伦比亚ADRC成立以来临床核心内一直存在的中央数据管理和生物统计资源和功能。旅游景点管理系统核心是五年前正式建立的，由两个协调良好的部门组成，一个负责生物统计/流行病学，另一个负责数据 管理功能.数据管理组件将继续管理一个大型、高度结构化的关系数据库，该数据库目前包含3，800多名受试者的大型队列的所有临床评价和神经病理学检查数据，包括自当前UDS开始以来收集的所有NACC UDS数据。在拟议的资助期内，数据库管理组件将继续以国家阿尔茨海默氏症管理局要求的格式以电子方式提交初始和后续UDS包。 协调中心（NACC）以最佳方式，并将作为本申请中描述的项目的数据，流行病学和统计资源的中心资源，以及与外部研究者和NACC发起的研究项目的批准合作。 统计和流行病学部分将与每个项目的调查人员密切合作，设计和执行统计分析，并协助编写和审查供出版的手稿。 统计和流行病学部分还将成为NACC合作项目的资源，并将参与设计和分析与外部和内部调查人员合作的特别研究工作。DMS核心的两个组成部分的工作人员将每周参加一次与其他核心和项目负责人的预定会议，以审查和讨论所有数据相关问题，包括：1）招募和随访; 2）临床和 神经病理学核心，以及4）项目和合作者对数据，统计规划和数据分析的需求。

The Database Management and Statistics Core (DMS) formalizes central data management and biostatistical resources and functions that have existed within the Clinical Core since the inception of the Columbia ADRC in 1989. The DMS Core, which was formally established five years ago, is composed of two component and well-coordinated arms, one for biostatistical/epidemiological and the other for data management functions. The Data Management Component will continue to manage a large, highly structured relational database currently containing all clinical evaluation and neuropathological examination data on a large cohort of over 3,800 subjects, including all NACC UDS data collected since the inception of the current UDS . In the proposed funding period the Database Management Component will continue to electronically submit initial and followup UDS packets in the format required by the National Alzheimer's Coordinafing Center (NACC) in a fimely manner, and will serve as a central resource for data, epidemiological and statistical resources to the projects described in this application, as well as to approved collaborations with external investigators and NACC-initiated research projects. The Statistics and Epidemiology Component will work closely with the investigators of each project to design and implement statistical analyses, and to assist in the preparation and review of manuscripts for publication. The Statistics and Epidemiology Component will also confinue to be a resource for collaborative NACC projects and will participate in the design and analysis of collaborative ad hoc research efforts with external and internal investigators. Staff of both components ofthe DMS Core will confinue to participate in weekly, scheduled meetings with leaders of the other cores and projects to review and discuss all data-related issues, including: 1) recruitment and followup ; 2) coordination of data fiow between the clinical and neuropathological cores, and 4) the needs ofthe projects and collaborators for data, stafisfical planning and data analysis.