Short Course on Next-Generation Sequencing: Technology and Statistical Methods

描述（由申请人提供）：这是一份为期三年的支持下一代测序技术和统计方法短期课程的申请，该课程于2011年在阿拉巴马大学伯明翰分校（UAB）首次推出。人们正在努力揭示许多复杂的人类疾病和数量性状的特定遗传成分。这些努力包括快速发展的下一代测序技术，这将产生前所未有的数据财富。随着基因组数据集的维度越来越大，生物医学研究人员需要越来越复杂的统计分析，以最大限度地从每项研究中收集信息。同样，研究复杂遗传性状的统计方法也取得了许多进展，新的统计方法也在不断涌现。我们认识到有必要整合临床研究人员和生物统计学家之间的分工，我们的目标是通过为新的研究人员配备必要的工具来进行技术和方法的前沿研究来满足这一需求。为了加快和显著推进对感兴趣的特定基因的搜索，我们提出了一系列关于下一代测序技术和统计基因组学的年度短期课程，这将使更多的研究人员，包括临床研究人员，参与、贡献和领导这类研究。这些短期课程将帮助学生、博士后研究员、初级研究人员和高级研究人员加快基因组的发现。这些课程将由下一代测序和统计遗传学/基因组学方面的顶尖专家教授。每4天的课程将提供对下一代测序、生物信息学和与这些技术相关的统计方法的新技术的大量熟悉，以及“动手”计算机培训，这将有效地增加从事遗传和基因组研究的研究人员的数量和专业知识。这是一门独特的课程，包含了下一代测序技术、生物信息学和统计方法的指导。我们预计大约50名学生参加每门课程，允许参与者和教师之间的密集互动。讲座将辅以广泛的讨论，动手计算，讲义和工作示例的展示。

DESCRIPTION (provided by applicant): This is a request for a three-year continuation of support for short courses on Next Generation Sequencing Technology and Statistical Methods, first launched in 2011 at the University of Alabama at Birmingham (UAB). Major efforts are underway to uncover the specific genetic components of many complex human disorders and quantitative traits. These efforts include rapidly evolving technologies for next-generation sequencing that will generate an unprecedented wealth of data. As genomic datasets take on greater dimensionality, biomedical researchers require increasingly sophisticated statistical analyses that maximize the information gleaned from each study. Likewise, many advances have been made in statistical methods for the study of complex genetic traits, and new statistical methods continue to be promulgated. We recognize a need to integrate the division of labor between clinical researchers and biostatisticians, and we aim to meet this need by equipping new investigators with the tools necessary to conduct research at the cutting edge of technology and methodology. To expedite and significantly advance the search for specific genes of interest, we propose a series of annual short courses on next-generation sequencing technologies and statistical genomics which will enable a far greater number of researchers, including clinical researchers, to participate in, contribute to, and lead such research. These short courses will help equip students, post- doctoral fellows, junior investigators and senior investigators to expedite genomic discovery. The courses will be taught by leading experts in next-generation sequencing and statistical genetics/genomics. Each 4-day courses will provide substantial familiarity with new technologies for next-generation sequencing, bioinformatics, and in statistical methods pertaining to these technologies and "hands-on" computer training that will effectively increase the number and the expertise of investigators who are pursuing genetic and genomic research. This is a unique course containing instructions in technology, bioinformatics, and statistical methods for next-generation sequencing. We expect approximately 50 students to attend each course, allowing for intensive interaction between participants and faculty. Lectures will be supplemented with extensive discussion sessions, hands-on computing, handouts, and presentation of worked examples.