UAB Statistical Genetics Post-Doctoral Training Program

描述(申请人提供)：分子生物学的持续发展、产生的海量数据和正在研究的表型的复杂性使人们迫切需要复杂的、创造性的、最终经过严格验证的新方法，同时也缺乏训练有素的统计遗传学/基因组学专业的个人。我们有组织但灵活的培训计划，提供2-3年的奖学金，为博士后科学家在统计遗传学/基因组学和心脏、肺和血液(HLB)相关研究方面的职业生涯做准备，并强调培养独立和创造性的研究计划。受训者必须有一个未来的调查职业目标。该计划旨在通过定期参加研究、课程和教学研讨会来发展独立、严格的调查技能。提供统计遗传学/基因组学基础和最先进的遗传/基因组分析计算工具方面的培训。应用经验是通过阿拉巴马大学伯明翰分校(UAB)与HLB相关的调查项目提供的。我们将通过新计划的工作坊提供心血管疾病、肺部疾病和血液相关疾病的HLB培训。UAB在发展统计遗传学部门方面投入了大量资金，因此有一个非常强大的统计遗传学家集中力量，提供了一个独特的培训环境。拟议的方案有几个显著的优势，包括：(1)统计遗传学/基因组和遗传流行病学教员人数众多，在以下主题方面具有专长：(A)研究设计，(B)大型和复杂家系的分析，(C)双胞胎和家庭数据的建模，(D)数学/理论统计，(E)微阵列数据的分析，(F)药物基因组学；(G)外显子组测序分析；(H)表观基因组数据分析；(I)下一代测序数据的分析；和(F)模型生物体的实验杂交分析；(2)与正在产生或拥有可应用统计基因技术的现有数据集的应用HLB研究人员密切合作；(3)在高级培训方面具有相当的热情和经验的教员；(4)我们大学为这项工作提供了大量的精神和物质支持，创造了一个充满活力、积极和充足的研究环境。受训者与统计遗传学的教员一起工作，并由HLB研究的合作教员共同指导。合作教员的多学科性质(内科医生、心理学家、统计学家、生理学家、遗传学家、流行病学家、心脏病专家、肺部疾病专家等)允许多学科体验。教职员工之间紧密的合作关系促进了这一方法的实施。

DESCRIPTION (provided by applicant): Continued advances in molecular biology, the vast data generated, and the complexity of the phenotypes being studied have made acute the need for sophisticated, creative, and ultimately rigorously validated novel methods and the simultaneous shortage of individuals well trained in statistical genetics/genomics. Our structured but flexible training program offers 2-3 year fellowships to prepare post-doctoral scientists for careers in statistical genetics/genomics and heart, lung and blood (HLB) related research and emphasizes growth of an independent and creative research program. Trainees must have a future goal of an investigative career. The program aims to develop independent rigorous investigative skills through regular participation in research, courses, and didactic seminars. Training is provided in foundations of statistical genetics/genomics and state-of-the-art computational tools in genetic/genomic analysis. Applied experience is provided via HLB-related investigative programs at the University of Alabama at Birmingham (UAB). We will provide HLB training through newly planned workshops in cardiovascular diseases, lungs and blood related diseases. UAB has invested heavily in development of a Section on Statistical Genetics and consequently has an unusually strong consolidated concentration of statistical geneticists offering a unique training environment. The proposed program has several notable strengths including: (1) A statistical genetics/genomic and genetic epidemiology faculty that is large in number and has expertise in topics spanning: (a) study design, (b) analysis of large and complex pedigrees, (c) modeling of twin and family data, (d) mathematical/theoretical statistics, (e) analysis of microarray data, (f) pharmacogenomics; (g) analysis of exome sequencing; (h) analysis of epigenomic data; (i) analysis of next generation sequencing data; and (f) analysis of experimental crosses in model organisms; (2) Close collaborative ties with applied HLB investigators who are producing or in possession of existing data sets to which statistical genetic techniques can be applied; (3) A faculty with substantial enthusiasm and experience in training at an advanced level; (4) Substantial support in both spirit and material are being provided for this effort by our University creating a dynamic, positive, and well-provisioned research environment. Trainees work with faculty in Statistical Genetics and are be jointly mentored by collaborating faculty in HLB research. The collaborating faculty's multidisciplinary nature (physicians, psychologists, statisticians, physiologists, geneticists, epidemiologists, cardiologists, pulmonary disease experts, etc.) allows multidisciplinary experience. Strong collaborative ties among the faculty facilitate this approach.