The BMRB as an evolving resource for biomolecular structure-function research
BMRB 作为生物分子结构功能研究的不断发展的资源
基本信息
- 批准号:8615052
- 负责人:
- 金额:$ 16.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-05-15 至 2019-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptedAdvisory CommitteesAlgorithmic SoftwareArchitectureArchivesBackBindingBioinformaticsBiologicalBiological MarkersBiological ProcessBiomedical ResearchBiomolecular Nuclear Magnetic ResonanceCarbohydratesChemicalsCollaborationsCommunicationCommunitiesComputer softwareComputersDataData AnalysesData SetDatabasesDepositionDevelopmentDiseaseEmerging TechnologiesEngineeringEuropeEvolutionFeedsFundingGoalsHeterogeneityHybridsImageryIndiumInternetJapanKnowledgeLinkLiteratureMagnetic ResonanceMagnetic Resonance SpectroscopyMedicalMetadataMethodsMiningMissionMolecular ConformationMolecular StructureNMR SpectroscopyNuclear Magnetic ResonanceNucleic AcidsOntologyPathway interactionsPeer ReviewPharmaceutical PreparationsProcessProtein ChemistryProtein DynamicsProteinsRelaxationResearchResourcesRetrievalRoleScienceScientistSideSiteSoftware ToolsSourceSpecific qualifier valueStructureSystemTechniquesTechnologyTherapeuticTrainingUniversitiesValidationWisconsinbiological systemsbiophysical techniqueschemical propertycollaboratorycomplex biological systemscomputerized data processingdata exchangedata modelingdesignflexibilityimprovedinnovationinnovative technologiesinsightmembernext generationnovelnucleic acid structureprotein structurepublic health relevancesimulationsoftware developmentstructural biologythree dimensional structuretoolweb services
项目摘要
PROJECT SUMMARY/ABSTRACT
The BioMagResBank (BMRB) is the unique worldwide resource that provides free access to the wealth of
information on biomolecules derived from nuclear magnetic resonance (NMR) spectroscopy. These NMR
experimental data underlie the three-dimensional structures of many proteins and nucleic acids and provide
important insights into their dynamics, chemical properties, and molecular interactions. BMRB maintains an
open architecture and a defined and flexible data model that makes it possible to respond rapidly to
changes in standards for data exchange and to the steady advances in NMR technology (greater variety of
archived data and increasingly detailed associated metadata). Data archived at BMRB include primary data
sets and derived results, such as chemical shifts, couplings, and cross relaxations associated with three-
dimensional structures, parameters that specify local dynamics, pKa values assigned to specific sites, H-
exchange rates, and evidence for conformational heterogeneity and molecular interactions. BMRB
integrates these NMR data into a unified, global, macromolecular structure database of general utility to the
broad scientific community. The growing volume and diversity of data available from BMRB are catalyzing
transformative scientific applications, such as the determination of protein structure and dynamics directly
from chemical shifts. BMRB and its collaborators develop improved software tools for integrating the
retrieval, analysis, and display of NMR data in the context of molecular structure and conformation. As a
member of the World Wide Protein Data Bank (wwPDB), BMRB has close ties with the three other wwPDB
partners: the Research Collaboratory for Structural Bioinformatics (RCSB), the Protein Data Bank in Europe
(PDBe), and the Protein Data Bank of Japan (PDBj). The ADIT-NMR deposition system developed by
BMRB in collaboration with the RCSB is responsible for acquiring over 95% of the new content brought into
the archive in the past year. BMRB collaborates with developers of software tools for extracting information
from NMR spectral data and for validating this information. The funds requested will enable BMRB (1) to
verify, reformat, archive, and distribute new data submitted electronically, (2) to maintain a productive
dialogue with users and creators of biomolecular NMR data, (3) to maintain and strengthen BMRB's role in
the wwPDB, (4) to collaborate with databanks specializing in related information so that useful links are
created, and (5) to interact with developers of new software and algorithms that make use of biomolecular
NMR data.
项目总结/摘要
BioMagResBank(BMRB)是唯一的全球资源,提供免费访问的财富,
来自核磁共振(NMR)光谱的生物分子信息。这些NMR
实验数据是许多蛋白质和核酸的三维结构的基础,
对它们的动力学、化学性质和分子相互作用的重要见解。BMRB保持
开放式体系结构和定义灵活的数据模型,使其能够快速响应
数据交换标准的变化以及NMR技术的稳步发展(
存档数据和越来越详细的相关元数据)。在BMRB存档的数据包括主要数据
集和衍生的结果,如化学位移,耦合,和交叉弛豫与三个-
三维结构,指定局部动力学的参数,分配给特定位点的pKa值,H-
交换率,以及构象异质性和分子相互作用的证据。BMRB
将这些NMR数据整合到统一的、全球性的、通用的大分子结构数据库中,
广泛的科学界。BMRB提供的数据量和多样性不断增长,
变革性的科学应用,如直接测定蛋白质结构和动力学
化学位移。BMRB及其合作者开发了改进的软件工具,
在分子结构和构象的背景下检索、分析和显示NMR数据。作为
作为世界蛋白质数据库(wwPDB)的成员,BMRB与其他三个wwPDB有着密切的联系
合作伙伴:结构生物信息学研究合作实验室(RCSB),欧洲蛋白质数据库
(PDBe)和日本蛋白质数据库(PDBj)。ADIT-NMR沉积系统由
BMRB与RCSB合作,负责获取95%以上的新内容。
去年的档案馆。BMRB与软件工具开发人员合作,
从NMR光谱数据和验证该信息。所要求的资金将使BMRB(1)能够
验证、重新格式化、存档和分发以电子方式提交的新数据,(2)保持生产效率
与生物分子NMR数据的用户和创建者对话,(3)保持和加强BMRB在以下方面的作用:
wwPDB,(4)与专门从事相关信息的数据库合作,
创建,和(5)与新的软件和算法,利用生物分子的开发人员互动
NMR数据。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JOHN LUTE MARKLEY其他文献
JOHN LUTE MARKLEY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JOHN LUTE MARKLEY', 18)}}的其他基金
Biogenesis of human mitochondrial iron-sulfur proteins
人类线粒体铁硫蛋白的生物合成
- 批准号:
10001537 - 财政年份:2019
- 资助金额:
$ 16.12万 - 项目类别:
The BMRB as an evolving resource for biomolecular structure-function research
BMRB 作为生物分子结构功能研究的不断发展的资源
- 批准号:
9462715 - 财政年份:2014
- 资助金额:
$ 16.12万 - 项目类别:
The BMRB as an evolving resource for biomolecular structure-function research
BMRB 作为生物分子结构功能研究的不断发展的资源
- 批准号:
9253407 - 财政年份:2014
- 资助金额:
$ 16.12万 - 项目类别:
The BMRB as an evolving resource for biomolecular structure-function research
BMRB 作为生物分子结构功能研究的不断发展的资源
- 批准号:
8852654 - 财政年份:2014
- 资助金额:
$ 16.12万 - 项目类别:
METABOLITE CHANGES IN E COLI STRAINS EVOLVED TO BE RADIATION RESISTANT
大肠杆菌菌株的代谢物变化进化为抗辐射性
- 批准号:
8361207 - 财政年份:2011
- 资助金额:
$ 16.12万 - 项目类别:
METHANOCALDOCOCCUS JANNASCHII COBY (MJ1117)
甲烷热球菌 JANNASCHII COBY (MJ1117)
- 批准号:
8361210 - 财政年份:2011
- 资助金额:
$ 16.12万 - 项目类别:
RELATIONSHIPS BETWEEN REDOX POTENTIAL, HYPERFINE SHIFTS, AND THE PKA(S)
氧化还原电位、超精细位移和 PKA 之间的关系
- 批准号:
8361161 - 财政年份:2011
- 资助金额:
$ 16.12万 - 项目类别:
相似海外基金
How novices write code: discovering best practices and how they can be adopted
新手如何编写代码:发现最佳实践以及如何采用它们
- 批准号:
2315783 - 财政年份:2023
- 资助金额:
$ 16.12万 - 项目类别:
Standard Grant
One or Several Mothers: The Adopted Child as Critical and Clinical Subject
一位或多位母亲:收养的孩子作为关键和临床对象
- 批准号:
2719534 - 财政年份:2022
- 资助金额:
$ 16.12万 - 项目类别:
Studentship
A material investigation of the ceramic shards excavated from the Omuro Ninsei kiln site: Production techniques adopted by Nonomura Ninsei.
对大室仁清窑遗址出土的陶瓷碎片进行材质调查:野野村仁清采用的生产技术。
- 批准号:
20K01113 - 财政年份:2020
- 资助金额:
$ 16.12万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2633211 - 财政年份:2020
- 资助金额:
$ 16.12万 - 项目类别:
Studentship
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2436895 - 财政年份:2020
- 资助金额:
$ 16.12万 - 项目类别:
Studentship
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2633207 - 财政年份:2020
- 资助金额:
$ 16.12万 - 项目类别:
Studentship
A Study on Mutual Funds Adopted for Individual Defined Contribution Pension Plans
个人设定缴存养老金计划采用共同基金的研究
- 批准号:
19K01745 - 财政年份:2019
- 资助金额:
$ 16.12万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The limits of development: State structural policy, comparing systems adopted in two European mountain regions (1945-1989)
发展的限制:国家结构政策,比较欧洲两个山区采用的制度(1945-1989)
- 批准号:
426559561 - 财政年份:2019
- 资助金额:
$ 16.12万 - 项目类别:
Research Grants
Securing a Sense of Safety for Adopted Children in Middle Childhood
确保被收养儿童的中期安全感
- 批准号:
2236701 - 财政年份:2019
- 资助金额:
$ 16.12万 - 项目类别:
Studentship
Structural and functional analyses of a bacterial protein translocation domain that has adopted diverse pathogenic effector functions within host cells
对宿主细胞内采用多种致病效应功能的细菌蛋白易位结构域进行结构和功能分析
- 批准号:
415543446 - 财政年份:2019
- 资助金额:
$ 16.12万 - 项目类别:
Research Fellowships














{{item.name}}会员




