Adolescent Social Relationships and Immune, Endocrine, and Metabolic Processes

青少年社会关系与免疫、内分泌和代谢过程

• 批准号: 8643092
• 负责人: Katherine Babcock Ehrlich
• 金额: $ 5.15万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8643092
• 关键词: Accounting; Address; Adolescence; Adolescent; Adult; Aging; Arterial Fatty Streak; Autoimmune Diseases; Behavior; Biological; Cardiovascular Diseases; Cause of Death; Characteristics; Chronic; Chronic Disease; Cognitive; Data; Data Set; Development; Disease; Disease Outcome; Endocrine; Environment; Family; Family Violence; Family member; Feedback; Fostering; Friends; Funding; Future; Glucocorticoid Receptor; Glucocorticoids; Goals; Health; Hydrocortisone; Immune; Immune system; Individual; Inflammation; Inflammatory; Lead; Life; Light; Link; Longitudinal Studies; Malignant Neoplasms; Mediator of activation protein; Mental Depression; Metabolic; Metabolic Control; Metabolism; Mission; Motion; National Institute of Child Health and Human Development; Neurosecretory Systems; Outcome; Output; Parenting behavior; Parents; Pathway interactions; Phenotype; Poverty; Predisposition; Process; Psychosocial Stress; Public Health; Regulation; Research; Research Design; Research Personnel; Resistance; Risk; Risk Factors; Role; Sampling; Shapes; Source; Staging; Testing; Time; United States; Variant; critical period; desensitization; examination questions; experience; heart disease risk; hypothalamic-pituitary-adrenal axis; immune function; insight; mortality; neglect; peer; programs; prospective; psychologic; psychosocial; public health relevance; social; stressor; theories

DESCRIPTION (provided by applicant): Recent research efforts have identified a connection between psychosocial stress, such as poverty, family violence, or neglect, and disease outcomes (e.g., Dube et al., 2009; Repetti, Taylor, & Seeman, 2002). Several studies have found that individuals who were raised in poor, stressful, and unsupportive environments are at increased risk for developing cardiovascular disease, autoimmune disease, and cancer (Danese et al., 2009; Dube et al., 2009; Keinan-Boker, Vin-Raviv, Liphshitz, Linn, & Barchana, 2009). These findings introduce important questions about the mechanisms through which psychosocial stressors influence the development and progression of chronic diseases. One possibility is that these environments foster chronic activation of the hypothalamic-pituitary-adrenal axis, leading to a progressive desensitization of glucocorticoid receptors and decreased ability of cortisol to regulate the immune system (Miller & Chen, 2010; Miller et al., 2009). Although much of the research on this possibility has emphasized the importance of environmental conditions very early in life (that is, within the first few years) as a sensitive peiod for the activation of a pro-inflammatory phenotype, there is reason to believe that adolescence may be another developmental period of increased vulnerability to environmental conditions that influence risk factors for later disease (Fuligni et al., 2009; Miller & Chen, 2010). Given that adolescent relationship experiences are often considered to be the most important features of adolescence (Lerner & Steinberg, 2009), the proposed research aims focus on the role of adolescents' close relationships as psychosocial predictors of immune, neuroendocrine, and metabolic processes. Using a prospective research design, adolescent social relationships will be examined as predictors of systemic inflammation and metabolic risk over a 2.5 year period. Then, basal cortisol levels and glucocorticoid sensitivity will be examined as mediators of links between social relationships and inflammation and metabolic risk. Finally, in a separate sample, links between adolescent social relationships and adult inflammation and metabolic risk will be examined over a 14 year period, thus capturing insight into the long- term influence of relationships on systemic inflammation and metabolic functioning. In line with the mission of the sponsoring agency, the proposed research will shed light on the ways in which adolescents' social relationships shape the developmental trajectory of immune, neuroendocrine, and metabolic processes that may contribute to long-term health and disease outcomes.

描述（由申请人提供）：最近的研究工作已经确定了社会心理压力（如贫困，家庭暴力或忽视）与疾病结果（例如，Dube等人，Repetti，Taylor，& Seeman，2002）.几项研究已经发现，在贫穷、压力大和缺乏支持的环境中长大的个体患心血管疾病、自身免疫性疾病和癌症的风险增加（Danese等人，2009; Dube等人，2009; Keinan-Boker，Vin-Raviv，Liphshitz，Linn，& Barchana，2009）.这些发现引入了关于心理社会压力影响慢性疾病发展和进展的机制的重要问题。一种可能性是这些环境促进下丘脑-垂体-肾上腺轴的慢性激活，导致糖皮质激素受体的进行性脱敏和皮质醇调节免疫系统的能力降低（米勒& Chen，2010;米勒et al.，2009年）。尽管关于这种可能性的许多研究已经强调了生命非常早期（即，在最初几年内）的环境条件作为促炎表型活化的敏感期的重要性，但是有理由相信青春期可能是对影响后期疾病的风险因素的环境条件的脆弱性增加的另一个发育期（Fuligni等人，2009;米勒和陈，2010）。鉴于青少年的关系经验通常被认为是青春期最重要的特征（Lerner & Steinberg，2009），建议的研究目标集中在青少年的亲密关系作为免疫，神经内分泌和代谢过程的社会心理预测因子的作用。使用前瞻性研究设计，青少年的社会关系将在2.5年的时间内作为全身炎症和代谢风险的预测因子进行检查。然后，基础皮质醇水平和糖皮质激素敏感性将作为社会关系与炎症和代谢风险之间联系的介质进行检查。最后，在一个单独的样本中，将在14年的时间内检查青少年社会关系与成人炎症和代谢风险之间的联系，从而深入了解关系对全身炎症和代谢功能的长期影响。根据赞助机构的使命，拟议的研究将阐明青少年的社会关系如何塑造免疫，神经内分泌和代谢过程的发展轨迹，这些过程可能有助于长期的健康和疾病结果。

项目成果

Balancing scientific accuracy and participant burden: testing the impact of sampling intensity on diurnal cortisol indices.

• DOI: 10.1080/10253890.2016.1206884
• 发表时间: 2016-09
• 期刊: STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
• 影响因子: 2.3
• 作者: Hoyt, Lindsay Till;Ehrlich, Katherine B.;Cham, Heining;Adam, Emma K.
• 通讯作者: Adam, Emma K.

Pre-transplant emotional support is associated with longer survival after allogeneic hematopoietic stem cell transplantation.

• DOI: 10.1038/bmt.2016.191
• 发表时间: 2016-12
• 期刊: BONE MARROW TRANSPLANTATION
• 影响因子: 4.8
• 作者: Ehrlich, K. B.;Miller, G. E.;Scheide, T.;Baveja, S.;Weiland, R.;Galvin, J.;Mehta, J.;Penedo, F. J.
• 通讯作者: Penedo, F. J.

Positive upshots of cortisol in everyday life.

在日常生活中皮质醇的积极结果。

• DOI: 10.1037/emo0000174
• 发表时间: 2016-06
• 期刊: Emotion (Washington, D.C.)
• 作者: Hoyt LT;Zeiders KH;Ehrlich KB;Adam EK
• 通讯作者: Adam EK