A Drosophila Model Investigates the Role of Metals in Initiating Urinary Stones

果蝇模型研究金属在引发尿路结石中的作用

• 批准号: 8737254
• 负责人: Marshall Stoller
• 金额: $ 31.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2015-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8737254
• 关键词: Affect; Aging; American; Atherosclerosis; Benign; Calculi; California; Clinic; Clinical; Discipline; Disease; Drosophila genus; Drosophila melanogaster; Educational workshop; Functional disorder; Genetic; Head; Image; Institution; Kidney Calculi; Leadership; Marshal; Metals; Modeling; Morbidity - disease rate; Osteoporosis; Outpatients; Patients; Pediatric Hospitals; Physiology; Play; Process; Published Comment; Qualifying; Research; Research Institute; Research Project Grants; Role; Running; San Francisco; Series; Universities; Urinary Calculi; Urologic Diseases; Urology; Work; calcification; cost; experience; medical specialties; metal metabolism; mineralization; novel; programs

This proposal seeks to develop a cross-disciplinary research center for the study of urinary stone disease at the University of California, San Francisco. Kidney stones are a benign urologic disease affecting millions of Americans annually. Our research has discovered that non-calcium metals may play a critical role in initiating kidney stone calcification. We have demonstrated that the calcification process underlying stone formation may be shared across a broad range of diseases, including atherosclerosis and osteoporosis. We have therefore established a network of cross-disciplinary collaborators to explore these connections. This include experts in genetics, metal metabolism, advanced imaging, and physiology. Our proposed core research project focuses on advancing our understanding of how metals may play a critical role in calcification and kidney stone formation utilizing a novel Drosophila melanogaster model for urinary stone disease. Work will be performed in conjunction with collaborators at the O'Brien Urology Research Center at the Mayo Clinic, the Buck Institute for Research on Aging, and the Children's Hospital of Oakland Research Center. This core project will bring together different disciplines and different institutions to approach understanding urinary stone disease from a new and broad viewpoint. Dr. Marshall Stoller, the Center Director for this proposal, brings more than 25 years of cross-disciplinary research and clinical experience to the leadership team and as the head of the UCSF urinary stone division, is well qualified to run the center. Our administrative core will support an educational program that will bring together additional diverse perspectives on mineralization for the study of urinary stone disease with a series of workshops that will develop new dialogues and collaborative efforts for research in this field. Establishment of this center will make a significant impact on advancing collaborative research in the field of benign urology and our understanding and treatment of urinary stone disease.

该建议旨在开发一个跨学科研究中心的尿石研究中心 加利福尼亚大学旧金山疾病。肾结石是一种良性泌尿科疾病 每年影响数百万美国人。我们的研究发现，非钙金属可能会发挥 在启动肾结石钙化中的关键作用。我们已经证明了钙化过程 潜在的石材形成可以在各种疾病中共享，包括动脉粥样硬化和 骨质疏松症。因此，我们已经建立了一个跨学科合作者网络来探索这些 连接。这包括遗传学专家，金属代谢，高级成像和生理学。 我们拟议的核心研究项目着重于促进我们对金属的理解 利用一种新型果蝇Melanogaster在钙化和肾结石形成中起关键作用 尿石疾病的模型。工作将与O'Brien的合作者一起进行 梅奥诊所的泌尿外科研究中心，巴克老化研究所和儿童的泌尿外科研究中心 奥克兰研究中心医院。这个核心项目将汇集不同的学科和不同的学科 从新的广泛观点开始了解尿石病的机构。 该提案中心主任马歇尔·斯托勒（Marshall Stoller）博士带来了超过25年的跨学科 领导团队的研究和临床经验，以及UCSF尿石部的负责人， 有资格运行中心。我们的行政核心将支持一项教育计划，该计划将带来 关于矿化的其他不同观点，用于研究尿石病 将在该领域进行研究的新对话和协作努力的研讨会。 该中心的建立将对推进合作研究的重大影响 良性泌尿外科领域以及我们对尿石病的理解和治疗。