Elucidating Essential Components of Bone Marrow Metastasis

项目概要/摘要 在许多致命癌症中观察到骨髓转移。肿瘤细胞优先迁移到 骨腔作为骨髓组成的函数。我们开发了一种组织工程 骨髓的类似物，并计划使用这种构建物来鉴定骨髓基质细胞的关键成分。 骨髓转移灶我们的目标是：1）建立一个微流控平台来捕获迁移性肿瘤 体外细胞，2）在芯片上创建肿瘤基质微环境，以及3）体内比较和治疗 BMSC支架对肿瘤生长的影响该项目将为候选人提供必要的培训， 微流体，成像和癌症生物学在K99培训期间，并推动他成为一个成功的 生物材料和肿瘤学领域的独立研究者，作为研究的R 00研究者 大学

Project Summary/Abstract Metastasis to the bone marrow is observed in a number of fatal cancers. Tumor cells preferentially migrate to the bone cavity as a function of composition of the bone marrow. We have developed a tissue engineered analogue of the bone marrow and plan to use this construct to identify the key stromal cellular components of a bone marrow metastatic niche. We propose to: 1) Develop a microfluidic platform to capture migratory tumor cells in vitro, 2) Create tumor-stroma microenvironments on-chip, and 3) In vivo comparison and treatment study of BMSC scaffolds on tumor growth. This project will provide essential training to candidate in microfluidics, imaging, and cancer biology during the K99 training period and propel him to be a successful independent investigator in the field of biomaterials and oncology as an R00 investigator at a research university.