Elucidating Essential Components of Bone Marrow Metastasis

阐明骨髓转移的重要组成部分

• 批准号: 8925016
• 负责人: Jungwoo Lee
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-10 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8925016
• 关键词: 3-Dimensional; Adipocytes; Adipose tissue; Biocompatible Materials; Blood Circulation; Blood Vessels; Bone Marrow; Bone Marrow Neoplasms; Bone Marrow Stem Cell; Breast; Cancer Biology; Cell Culture Techniques; Cells; Cessation of life; Development; Discontinuous Capillary; Distant; Engineering; Engraftment; Goals; Growth; Growth and Development function; Hematopoietic stem cells; Human; Image; Implant; In Vitro; Location; Lung; Malignant Neoplasms; Mammary Neoplasms; Marrow; Mediating; Mesenchymal Stem Cells; Metastatic Neoplasm to the Bone Marrow; Microfluidics; Modeling; Molecular; Mus; Neoplasm Metastasis; Osteoblasts; Pharmaceutical Preparations; Positioning Attribute; Preparation; Process; Prostate; Public Health; Recruitment Activity; Research; Research Personnel; Site; Skin; Stromal Cells; System; Technology; Therapeutic; Tissue Engineering; Tissue Model; Training; Tumor Biology; Undifferentiated; Universities; abstracting; analog; bone; cancer cell; carcinogenesis; chemokine; improved; in vivo; leukemia; malignant breast neoplasm; microchip; microsystems; migration; neoplastic cell; oncology; osteogenic; prevent; prostate cancer cell; scaffold; therapeutic target; tumor; tumor growth; tumor microenvironment

Project Summary/Abstract Metastasis to the bone marrow is observed in a number of fatal cancers. Tumor cells preferentially migrate to the bone cavity as a function of composition of the bone marrow. We have developed a tissue engineered analogue of the bone marrow and plan to use this construct to identify the key stromal cellular components of a bone marrow metastatic niche. We propose to: 1) Develop a microfluidic platform to capture migratory tumor cells in vitro, 2) Create tumor-stroma microenvironments on-chip, and 3) In vivo comparison and treatment study of BMSC scaffolds on tumor growth. This project will provide essential training to candidate in microfluidics, imaging, and cancer biology during the K99 training period and propel him to be a successful independent investigator in the field of biomaterials and oncology as an R00 investigator at a research university.

项目总结/文摘