Development of breakthrough intra-operative detector and imaging system for parat

开发突破性的术中探测器和成像系统

• 批准号: 8715217
• 负责人: Anita Mahadevan-Jansen
• 金额: $ 59.16万
• 依托单位: ANASYS INSTRUMENTS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8715217
• 关键词: Accidental Injury; Address; Adverse effects; Advocate; Calcium; Data; Detection; Development; Diffuse; Disease; Endocrine; Engineering; Excision; Eye; Fatty acid glycerol esters; Fluorescence; Goals; Goggles; Health; Healthcare Systems; Homeostasis; Hormones; Hypocalcemia result; Hypoparathyroidism; Image; Incidence; Injury; Lasers; Lead; Length of Stay; Lighting; Lymph; Lymph Node Dissections; Lymph Node Involvement; Malignant Lymph Node Neoplasm; Malignant Neoplasms; Malignant neoplasm of thyroid; Morbidity - disease rate; Neck; Neck Dissection; Neoplasm Metastasis; Operative Surgical Procedures; Parathyroid gland; Parathyroidectomy; Patients; Phase; Procedures; Production; Protocols documentation; Relative (related person); Reporting; Research; Safety; Scanning; Small Business Technology Transfer Research; Spectrum Analysis; Surgeon; System; Techniques; Technology; Thyroid Gland; Thyroidectomy; Time; Tissues; Touch sensation; Universities; Vascularization; Work; base; cancer cell; cancer surgery; cost; design; detector; imaging detector; lymph nodes; prevent; prophylactic; prototype

Project Summary / Abstract There are 4 parathyroid glands in the neck and they are responsible for the production of parathyroid hormone which maintains calcium homeostasis throughout the body. They are difficult to identify relative to the other tissues in the neck such as lymph nodes, fat, thyroid etc. This has resulted in the incidence of accidental parathyroid removal ranging from 8% to 19% of patients undergoing total thyroidectomy . Damage to the parathyroid gland(s) can cause hypoparathyroidism and hypocalcemia resulting in serious and deleterious side effects. There are 3 different surgery procedures in the neck region where a key part of surgery protocol is for the surgeon to visually identify the parathyroid clearly to avoid accidental injury and removal. These are Thyroidectomy (involving partial or complete removal of thyroid), Parathyroidectomy (involving removal of one or more parathyroid glands) and modified Neck Dissection (involving removal of lymph nodes in neck into which cancer has spread). In a recent discovery, the PI Prof. Mahadevan-Jansen's group at Vanderbilt University reported for the first time the breakthrough finding that the Parathyroid Gland has a unique autofluorescence signature in the NIR under illumination at 785nm. The Phase 1 research demonstrated a prototype platform based on this technology that could do point detection and imaging. The specific aims of this proposal is to build upon that work and it seeks to a) Develop a product that can function in two modes: ¿ A point detection mode that can be used to confirm if a candidate tissue is parathyroid or not ¿ An imaging mode that can be used to look at a region to guide the surgeon to then using the point detection mode to confirm b) To investigate the use of the auto-fluorescence technology to assess lymph nodes intra-operatively for cancer metastases. c) To detect parathyroid vascularization via diffuse reflectance spectroscopy

项目总结/摘要 颈部有4个甲状旁腺，它们负责产生甲状旁腺激素 它能维持整个身体的钙稳态。他们很难确定相对于其他 颈部的组织，如淋巴结，脂肪，甲状腺等，这导致了意外的发病率 甲状旁腺切除率为8%-19%。损坏 甲状旁腺可引起甲状旁腺功能减退和低钙血症， 副作用. 颈部有3种不同的手术程序，其中手术方案的关键部分是 外科医生应清楚地目视识别甲状旁腺，以避免意外损伤和切除。这些是 甲状腺切除术（包括部分或全部切除甲状腺），甲状旁腺切除术（包括切除一个 或更多的甲状旁腺）和改良的颈部清扫术（包括切除颈部淋巴结， 癌症扩散）。 在最近的一项发现中，范德比尔特大学的PI教授Mahadevan-Jansen的小组首次报告了 时间的突破性发现，甲状旁腺有一个独特的自体荧光签名在近红外 在785 nm下照射。第一阶段的研究展示了基于此的原型平台 可以进行点检测和成像的技术。 本提案的具体目标是在这项工作的基础上再接再厉， a）开发一个可以在两种模式下运行的产品： <$点检测模式，可用于确认候选组织是否为甲状旁腺 ？一种成像模式，可用于查看一个区域，以指导外科医生使用 点检测模式确认 B）研究使用自体荧光技术在术中评估淋巴结， 癌症转移 c）通过漫反射光谱检测甲状旁腺血管化