Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)

描述（由申请人提供）：跨学科神经艾滋病成瘾研究培训（TRAIN）药物滥用和艾滋病毒感染对大脑结构和功能的综合影响的跨学科临床研究与公共卫生倡议具有相当大的相关性。然而，目前很少有实验室进行这样的研究，目前也没有专门的培训计划来准备下一代研究人员在成瘾和神经艾滋病交叉的临床研究。因此，我们建议设立一个新的Ruth L. Kirschstein国家研究服务奖机构培训补助金（NRSA T32），题为“跨学科神经艾滋病成瘾研究培训（TRAIN）”。TRAIN的目标是为临床神经心理学的多学科学术生涯准备四名博士生和两名博士后，专注于药物滥用和HIV感染的中枢神经系统（CNS）效应。我们将招收一批高素质、文化多元化的学员，他们有望在学术生涯中取得丰硕成果。TRAIN计划将强调三个主要的、相互关联的中枢神经系统结果的研究培训，之所以选择这些结果，是因为它们作为hiv感染药物滥用者的临床特征的显著性和公共卫生相关性：(1)神经认知障碍（如决策、记忆）；(2)日常功能（如药物依从性、职业结果）；(3)结构和功能神经成像（如弥散张量成像）。学生和研究员将积极参与个性化、灵活的职业发展计划，包括应用研究培训、教学（例如，正式的课堂作业和结构化的研讨会）和有针对性的临床经验。我们将有一个具有强烈培训兴趣和长期合作研究历史的有成就的教师来指导学员。在神经损伤、神经影像学、神经心理学、药物滥用和艾滋病毒感染的日常功能方面，TRAIN的教师由20名来自多个学科的导师组成，他们拥有相当多的专业知识。培训将由Steven Paul Woods博士和联合董事、Dr.。Igor Grant和Robert K. Heaton，他们将监督项目的所有培训、科学和管理方面，包括严格的内部和外部评估过程。TRAIN项目将设在加州大学圣地亚哥分校的精神病学院系内，在那里它将受益于资源丰富的学术环境，包括强大的药物滥用和神经艾滋病研究基础设施，最著名的是nida资助的转化甲基苯丙胺艾滋病研究中心（TMARC）。总而言之，TRAIN将汇集一批聪明而多样化的pre- and - post-doctoral受训者，一个有成就的多学科导师团队，一个有效的管理结构，以及广泛的学术资源，为国家的下一代学者做好准备，他们将推动药物滥用和神经艾滋病的科学和实践。

DESCRIPTION (provided by applicant): Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN) Interdisciplinary clinical research on the combined effects of substance abuse and HIV infection on brain structure and function is of considerable relevance to public health initiatives. However, there are presently very few laboratories conducting such research and no current training programs dedicated to preparing the next generation of investigators in clinical research at the intersection of addictions and neuroAIDS. Accordingly, we propose to establish a new Ruth L. Kirschstein National Research Service Award Institutional Training Grant (NRSA T32) entitled, "Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)." The aim of TRAIN is to prepare a steady state of four pre-doctoral students and two post-doctoral fellows in clinical neuropsychology for multidisciplinary academic careers focused on the central nervous system (CNS) effects of substance abuse and HIV infection. We will recruit a highly qualified and culturally diverse cohort of trainees that demonstrate promise toward achieving productive academic careers. The TRAIN program will emphasize research training in three primary, interrelated CNS outcomes, which were selected because of their salience and public health relevance as clinical features of HIV-infected substance abusers: (1) neurocognitive impairment (e.g., decision-making, memory); (2) everyday functioning (e.g., medication adherence, vocational outcomes); and (3) structural and functional neuroimaging (e.g., diffusion tensor imaging). Students and fellows will be actively engaged in individualized, flexible career development plans that will include applied research training, didactics (e.g., formal class work and structured seminars), and targeted clinical experiences. An accomplished faculty with strong training interests and a long history of collaborative research will be available to mentor the trainees. The TRAIN faculty consists of 20 mentors across multiple academic disciplines that possess considerable expertise in neural injury, neuroimaging, neuropsychology, and everyday functioning in substance abuse and HIV infection. TRAIN will be led by Dr. Steven Paul Woods and Co-Directors, Drs. Igor Grant and Robert K. Heaton, who will oversee all of the training, scientific, and administrative aspects of the program, including a rigorous process of internal and external evaluation. The TRAIN program will be housed within the Department of Psychiatry at the University of California, San Diego, where it will benefit from a resource rich academic environment that includes a strong substance abuse and neuroAIDS research infrastructure, most notably the NIDA-funded Translational Methamphetamine AIDS Research Center (TMARC). In summary, TRAIN will bring together a bright and diverse cohort of pre- and post-doctoral trainees, an accomplished multidisciplinary team of mentors, an effective administrative structure, and broad array of academic resources to prepare the Nation's next generation of academics who will advance the science and practice of substance abuse and neuroAIDS.