Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)

描述（由申请人提供）：跨学科NeuroAIDS（TRAIN）成瘾研究培训关于药物滥用和HIV感染对大脑结构和功能的综合影响的跨学科临床研究与公共卫生倡议具有相当大的相关性。然而，目前很少有实验室进行这样的研究，目前也没有专门的培训计划，以准备下一代的研究人员在成瘾和神经艾滋病的交叉临床研究。因此，我们建议建立一个新的露丝L。Kirschstein国家研究服务奖机构培训补助金（NRSA T32），题为“跨学科神经艾滋病成瘾研究培训”。“训练的目的是为临床神经心理学的四名博士前学生和两名博士后研究员准备一个稳定的状态，从事多学科的学术事业，重点是药物滥用和艾滋病毒感染对中枢神经系统的影响。我们将招募一批高素质和文化多样性的学员，这些学员将有希望实现富有成效的学术生涯。TRAIN计划将强调在三个主要的、相互关联的中枢神经系统结果方面的研究培训，之所以选择这些结果，是因为它们作为艾滋病毒感染的物质滥用者的临床特征具有显著性和公共卫生相关性：（1）神经认知障碍（例如，决策、记忆）;（2）日常功能（例如，药物依从性，职业结果）;和（3）结构和功能神经成像（例如，扩散张量成像）。学生和研究员将积极参与个性化，灵活的职业发展计划，其中包括应用研究培训，教学法（例如，正式的课堂作业和结构化的研讨会），以及有针对性的临床经验。一个有着浓厚的培训兴趣和长期合作研究历史的有成就的教师将指导学员。培训教师由20名导师组成，他们横跨多个学科，在神经损伤，神经影像学，神经心理学以及药物滥用和艾滋病毒感染的日常功能方面拥有相当丰富的专业知识。培训将由史蒂文·保罗·伍兹博士和联合主任伊戈尔·格兰特博士和罗伯特·K·希顿，谁将监督所有的培训，科学和行政方面的计划，包括严格的内部和外部评估过程。培训计划将设在圣地亚哥加州大学精神病学系，在那里它将受益于资源丰富的学术环境，包括强大的药物滥用和神经艾滋病研究基础设施，最值得注意的是NIDA资助的转化甲基苯丙胺艾滋病研究中心（TMARC）。总之，培训将汇集一个光明的和多样化的队列的前和博士后学员，一个有成就的多学科团队的导师，一个有效的行政结构，和广泛的学术资源，以准备国家的下一代学者谁将推进科学和药物滥用和神经艾滋病的实践。

DESCRIPTION (provided by applicant): Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN) Interdisciplinary clinical research on the combined effects of substance abuse and HIV infection on brain structure and function is of considerable relevance to public health initiatives. However, there are presently very few laboratories conducting such research and no current training programs dedicated to preparing the next generation of investigators in clinical research at the intersection of addictions and neuroAIDS. Accordingly, we propose to establish a new Ruth L. Kirschstein National Research Service Award Institutional Training Grant (NRSA T32) entitled, "Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)." The aim of TRAIN is to prepare a steady state of four pre-doctoral students and two post-doctoral fellows in clinical neuropsychology for multidisciplinary academic careers focused on the central nervous system (CNS) effects of substance abuse and HIV infection. We will recruit a highly qualified and culturally diverse cohort of trainees that demonstrate promise toward achieving productive academic careers. The TRAIN program will emphasize research training in three primary, interrelated CNS outcomes, which were selected because of their salience and public health relevance as clinical features of HIV-infected substance abusers: (1) neurocognitive impairment (e.g., decision-making, memory); (2) everyday functioning (e.g., medication adherence, vocational outcomes); and (3) structural and functional neuroimaging (e.g., diffusion tensor imaging). Students and fellows will be actively engaged in individualized, flexible career development plans that will include applied research training, didactics (e.g., formal class work and structured seminars), and targeted clinical experiences. An accomplished faculty with strong training interests and a long history of collaborative research will be available to mentor the trainees. The TRAIN faculty consists of 20 mentors across multiple academic disciplines that possess considerable expertise in neural injury, neuroimaging, neuropsychology, and everyday functioning in substance abuse and HIV infection. TRAIN will be led by Dr. Steven Paul Woods and Co-Directors, Drs. Igor Grant and Robert K. Heaton, who will oversee all of the training, scientific, and administrative aspects of the program, including a rigorous process of internal and external evaluation. The TRAIN program will be housed within the Department of Psychiatry at the University of California, San Diego, where it will benefit from a resource rich academic environment that includes a strong substance abuse and neuroAIDS research infrastructure, most notably the NIDA-funded Translational Methamphetamine AIDS Research Center (TMARC). In summary, TRAIN will bring together a bright and diverse cohort of pre- and post-doctoral trainees, an accomplished multidisciplinary team of mentors, an effective administrative structure, and broad array of academic resources to prepare the Nation's next generation of academics who will advance the science and practice of substance abuse and neuroAIDS.