Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)

项目摘要/摘要 药物滥用与HIV疾病联合作用的跨学科临床研究 中枢神经系统(CNS)对公共卫生具有相当重要的意义。尽管如此，很少有实验室 解决这一关键问题，当前的培训计划是唯一专门为下一步做准备的培训计划 一代调查人员进行这项研究。在我们的NRSA T32建议的第二次续订中 培训基金“跨学科神经艾滋病成瘾研究培训(TRAIN)”，我们的目标是 加快我们对这一领域的贡献。我们将继续招聘有才华和多样化的人才 博士生，他们的学术发展将由一个成熟的多学科团队来推动 加州大学圣地亚哥分校的导师和广泛的学术资源。列车在以下方面非常成功 当前资助期--自2016年以来，8名学员撰写了55篇研究手稿(22篇为第一作者)， 88个会议报告和6个书籍章节，以及2个国家卫生研究院资助的外部赠款(1个 审查，影响分数=21，第二个百分位数)，3项国家卫生研究院资助赠款的补充，以及2项校内试点赠款。 在第二次更新中，我们计划通过增加教师的专业知识、教学方法、 和新方法论方面的培训，以支持我们复杂生物学的新补充主题 艾滋病毒和药物使用的中枢神经系统后果的潜在机制。特别关注的因素 包括微生物组和肠道脑轴、全身和中枢神经系统炎症、神经免疫学和 生物标志物。这一重点将增强神经行为功能的训练连续性主题(例如，额叶 系统行为、决策、记忆)和与健康相关的日常功能(例如，治疗 坚持、职业成果)。鉴于我们之前的成功和该领域日益增长的需求，我们 建议将我们的稳定实习生人数增加到四名博士后和三名博士后实习生。我们的 学生和研究员将积极参与个性化的职业发展计划，如应用 研究培训、教学和有针对性的临床经验。培训教师，所有人都接受过强有力的培训 对协作研究的兴趣和丰富的历史，由25名主要导师组成，涵盖多个 学术水平和学科，在上述科学主题方面拥有相当多的专业知识。 我们还加强了组织结构(例如，增加内部培训委员会)，以进一步 确保在实现实习生目标方面继续取得进展。列车由R.Heaton，Co- 董事I.Grant和D.Moore(这是新角色)，副董事J.Iudicello和E.Morgan； 团队将监督该计划的所有培训、科学和管理方面。火车将被安置在 在精神病学系内的HNRP-CMCR，这是一个资源丰富的研究和培训 药物滥用和神经艾滋病毒研究中的环境。我们的中心目标不变：训练， 指导和指导下一代研究人员关于艾滋病毒和药物使用对中枢神经系统的综合影响。

PROJECT SUMMARY/ABSTRACT Interdisciplinary clinical research on the combined effects of substance abuse and HIV disease on the central nervous system (CNS) is of considerable public health importance. Despite this, few laboratories address this critical topic and the current training program is the only one dedicated to preparing the next generation of investigators to conduct this research. In this proposed second renewal of our NRSA T32 training grant, “Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN),” we aim to accelerate our contribution to the field. We will continue to recruit talented and diverse pre- and post- doctoral trainees whose academic development will be furthered by an accomplished multidisciplinary team of mentors and the extensive academic resources at UC San Diego. TRAIN has been highly successful in the current funding period–since 2016, the 8 trainees produced 55 research manuscripts (22 first-authored), 88 conference presentations, and 6 book chapters, as well as 2 extramural NIH-funded grants (1 under review, impact score=21, 2nd percentile), 3 supplements to NIH-funded grants, and 2 intramural pilot grants. In this second renewal, we plan to enhance our training grant by augmenting faculty expertise, didactics, and training in new methodologies to support our new complementary theme of the complex biological mechanisms underlying the CNS consequences of HIV and substance use. Factors of particular focus include the microbiome and gut brain-axis, systemic and CNS inflammation, neuroimmunology, and biomarkers. This focus will augment TRAIN continuity themes of neurobehavioral functioning (e.g., frontal systems behaviors, decision-making, memory) and health-related everyday functioning (e.g., treatment adherence, vocational outcomes). Given our previous success and the growing demands of the field, we propose to increase our steady state number of trainees to four pre- and three post-doctoral trainees. Our students and fellows will be actively engaged in individualized career development plans, such as applied research training, didactics, and targeted clinical experiences. TRAIN faculty, all with strong training interests and robust histories of collaborative research, consists of 25 primary mentors across multiple academic levels and disciplines, with considerable expertise across the aforementioned scientific themes. We also have made organizational enhancements (e.g., addition of internal TRAIN committees) to further ensure continued progress towards the accomplishment of trainee goals. TRAIN is led by R. Heaton, Co- Directors I. Grant and D. Moore (new to this role), and Associate Directors J. Iudicello and E. Morgan; this team will oversee all training, scientific, and administrative aspects of the program. TRAIN will be housed at the HNRP-CMCR within the Department of Psychiatry, which is a resource-rich research and training environment in substance abuse and neuroHIV research. Our central goal remains unchanged: to train, mentor, and guide the next generation of researchers on combined CNS effects of HIV and substance use.