Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)

项目概要/摘要 关于药物滥用和艾滋病毒疾病对人类健康的综合影响的跨学科临床研究 中枢神经系统（CNS）对公共卫生具有相当重要的意义。尽管如此，很少有实验室 解决这一关键主题，当前的培训计划是唯一致力于为下一个主题做准备的培训计划 一代研究人员进行这项研究。在我们提议的 NRSA T32 的第二次更新中 培训补助金，“跨学科神经艾滋病成瘾研究培训（TRAIN）”，我们的目标是 加快我们对该领域的贡献。我们将继续招募才华横溢、多元化的职前和职后人员 博士生的学术发展将由一个优秀的多学科团队促进 加州大学圣地亚哥分校的导师和广泛的学术资源。 TRAIN 在以下方面取得了巨大成功 本资助期——2016年以来，8名学员共发表研究论文55篇（其中第一作者22篇）， 88 次会议演讲、6 个书籍章节以及 2 项 NIH 资助的校外赠款（其中 1 项属于 审查，影响分数 = 21，第二个百分位），3 项 NIH 资助的补助金补充，以及 2 项校内试点补助金。 在第二次更新中，我们计划通过增强教师的专业知识、教学法、 以及新方法的培训，以支持我们复杂生物的新补充主题 HIV 和物质使用的中枢神经系统后果的潜在机制。特别关注的因素 包括微生物组和肠脑轴、全身和中枢神经系统炎症、神经免疫学和 生物标志物。这一重点将增强 TRAIN 神经行为功能的连续性主题（例如，额叶 系统行为、决策、记忆）和与健康相关的日常功能（例如，治疗 坚持、职业成果）。鉴于我们之前的成功以及该领域不断增长的需求，我们 建议将我们的稳态受训人员数量增加到四名博士前受训人员和三名博士后受训人员。我们的 学生和研究员将积极参与个性化的职业发展计划，例如应用 研究培训、教学和有针对性的临床经验。 TRAIN 师资力量，均受过严格培训 兴趣和合作研究的悠久历史，由来自多个领域的 25 位主要导师组成 学术水平和学科，在上述科学主题方面拥有丰富的专业知识。 我们还进行了组织改进（例如，增加内部 TRAIN 委员会）以进一步 确保在实现学员目标方面不断取得进展。 TRAIN 由 R. Heaton 领导，Co- 董事 I. Grant 和 D. Moore（新任董事），以及副董事 J. Iudicello 和 E. Morgan；这个 团队将监督该计划的所有培训、科学和行政方面。 TRAIN将被安置 在精神病学系内的 HNRP-CMCR，这是一个资源丰富的研究和培训中心 药物滥用和神经艾滋病毒研究的环境。我们的中心目标保持不变：训练、 导师，并指导下一代研究人员研究艾滋病毒和药物滥用对中枢神经系统的综合影响。

PROJECT SUMMARY/ABSTRACT Interdisciplinary clinical research on the combined effects of substance abuse and HIV disease on the central nervous system (CNS) is of considerable public health importance. Despite this, few laboratories address this critical topic and the current training program is the only one dedicated to preparing the next generation of investigators to conduct this research. In this proposed second renewal of our NRSA T32 training grant, “Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN),” we aim to accelerate our contribution to the field. We will continue to recruit talented and diverse pre- and post- doctoral trainees whose academic development will be furthered by an accomplished multidisciplinary team of mentors and the extensive academic resources at UC San Diego. TRAIN has been highly successful in the current funding period–since 2016, the 8 trainees produced 55 research manuscripts (22 first-authored), 88 conference presentations, and 6 book chapters, as well as 2 extramural NIH-funded grants (1 under review, impact score=21, 2nd percentile), 3 supplements to NIH-funded grants, and 2 intramural pilot grants. In this second renewal, we plan to enhance our training grant by augmenting faculty expertise, didactics, and training in new methodologies to support our new complementary theme of the complex biological mechanisms underlying the CNS consequences of HIV and substance use. Factors of particular focus include the microbiome and gut brain-axis, systemic and CNS inflammation, neuroimmunology, and biomarkers. This focus will augment TRAIN continuity themes of neurobehavioral functioning (e.g., frontal systems behaviors, decision-making, memory) and health-related everyday functioning (e.g., treatment adherence, vocational outcomes). Given our previous success and the growing demands of the field, we propose to increase our steady state number of trainees to four pre- and three post-doctoral trainees. Our students and fellows will be actively engaged in individualized career development plans, such as applied research training, didactics, and targeted clinical experiences. TRAIN faculty, all with strong training interests and robust histories of collaborative research, consists of 25 primary mentors across multiple academic levels and disciplines, with considerable expertise across the aforementioned scientific themes. We also have made organizational enhancements (e.g., addition of internal TRAIN committees) to further ensure continued progress towards the accomplishment of trainee goals. TRAIN is led by R. Heaton, Co- Directors I. Grant and D. Moore (new to this role), and Associate Directors J. Iudicello and E. Morgan; this team will oversee all training, scientific, and administrative aspects of the program. TRAIN will be housed at the HNRP-CMCR within the Department of Psychiatry, which is a resource-rich research and training environment in substance abuse and neuroHIV research. Our central goal remains unchanged: to train, mentor, and guide the next generation of researchers on combined CNS effects of HIV and substance use.