Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)

跨学科神经艾滋病成瘾研究培训（TRAIN）

• 批准号: 10622552
• 负责人: ROBERT Kernachan HEATON
• 金额: $ 42.72万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10622552
• 关键词: Research; Training; addiction; neuroAIDS

PROJECT SUMMARY/ABSTRACT Interdisciplinary clinical research on the combined effects of substance abuse and HIV disease on the central nervous system (CNS) is of considerable public health importance. Despite this, few laboratories address this critical topic and the current training program is the only one dedicated to preparing the next generation of investigators to conduct this research. In this proposed second renewal of our NRSA T32 training grant, “Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN),” we aim to accelerate our contribution to the field. We will continue to recruit talented and diverse pre- and post- doctoral trainees whose academic development will be furthered by an accomplished multidisciplinary team of mentors and the extensive academic resources at UC San Diego. TRAIN has been highly successful in the current funding period–since 2016, the 8 trainees produced 55 research manuscripts (22 first-authored), 88 conference presentations, and 6 book chapters, as well as 2 extramural NIH-funded grants (1 under review, impact score=21, 2nd percentile), 3 supplements to NIH-funded grants, and 2 intramural pilot grants. In this second renewal, we plan to enhance our training grant by augmenting faculty expertise, didactics, and training in new methodologies to support our new complementary theme of the complex biological mechanisms underlying the CNS consequences of HIV and substance use. Factors of particular focus include the microbiome and gut brain-axis, systemic and CNS inflammation, neuroimmunology, and biomarkers. This focus will augment TRAIN continuity themes of neurobehavioral functioning (e.g., frontal systems behaviors, decision-making, memory) and health-related everyday functioning (e.g., treatment adherence, vocational outcomes). Given our previous success and the growing demands of the field, we propose to increase our steady state number of trainees to four pre- and three post-doctoral trainees. Our students and fellows will be actively engaged in individualized career development plans, such as applied research training, didactics, and targeted clinical experiences. TRAIN faculty, all with strong training interests and robust histories of collaborative research, consists of 25 primary mentors across multiple academic levels and disciplines, with considerable expertise across the aforementioned scientific themes. We also have made organizational enhancements (e.g., addition of internal TRAIN committees) to further ensure continued progress towards the accomplishment of trainee goals. TRAIN is led by R. Heaton, Co- Directors I. Grant and D. Moore (new to this role), and Associate Directors J. Iudicello and E. Morgan; this team will oversee all training, scientific, and administrative aspects of the program. TRAIN will be housed at the HNRP-CMCR within the Department of Psychiatry, which is a resource-rich research and training environment in substance abuse and neuroHIV research. Our central goal remains unchanged: to train, mentor, and guide the next generation of researchers on combined CNS effects of HIV and substance use.

项目总结/摘要 药物滥用和艾滋病对艾滋病毒感染者的综合影响的跨学科临床研究 中枢神经系统（CNS）具有相当大的公共卫生重要性。尽管如此，很少有实验室 解决这一关键问题，目前的培训计划是唯一一个致力于准备下一个 研究人员来进行这项研究。在我们的NRSA T32的第二次更新中， 培训补助金，"跨学科神经艾滋病成瘾研究培训"，我们的目标是 加快我们对该领域的贡献。我们将继续招聘有才华和多样化的前和后， 博士生的学术发展将由一个有成就的多学科团队进一步推动 导师和加州大学圣地亚哥分校广泛的学术资源。火车已经非常成功， 当前资助期--自2016年以来，8名学员共撰写了55篇研究论文（其中22篇为第一作者）， 88次会议演讲，6本书的章节，以及2个校外NIH资助的赠款（1个在 审查，影响评分= 21，第二百分位数），3补充NIH资助的补助金，和2校内试点补助金。 在第二次更新中，我们计划通过增加教师的专业知识，教学法， 和新方法的培训，以支持我们新的互补主题， HIV和药物使用对CNS影响的潜在机制。特别关注的因素 包括微生物组和肠脑轴，全身性和CNS炎症，神经免疫学， 生物标志物。这一重点将增强神经行为功能的TRAIN连续性主题（例如，正面 系统行为、决策、记忆）和健康相关的日常功能（例如，治疗 坚持，职业成果）。鉴于我们之前的成功和该领域不断增长的需求，我们 建议把见习生的稳定人数增至四名博士前见习生及三名博士后见习生。我们 学生和研究员将积极参与个性化的职业发展计划，如应用 研究培训、教学法和有针对性的临床经验。培训教师，都经过严格的培训 兴趣和合作研究的强大历史，由25个主要导师在多个 学术水平和学科，在上述科学主题方面具有相当的专业知识。 我们还进行了组织改进（例如，增加内部培训委员会）， 确保继续朝着学员目标的实现取得进展。列车由R。希顿公司 董事I. Grant和D.摩尔（新上任）和副主任J。摩根;这 该小组将监督该计划的所有培训、科学和行政方面。火车将被安置在 在精神病学系内的HNRP-CMCR，这是一个资源丰富的研究和培训 药物滥用和神经艾滋病研究的环境。我们的中心目标保持不变：培训， 导师，并指导下一代研究人员对艾滋病毒和物质使用的联合中枢神经系统的影响。

项目成果

Evaluation of Field Sobriety Tests for Identifying Drivers Under the Influence of Cannabis: A Randomized Clinical Trial.

• DOI: 10.1001/jamapsychiatry.2023.2345
• 发表时间: 2023-09-01
• 期刊: JAMA PSYCHIATRY
• 影响因子: 25.8
• 作者: Marcotte, Thomas D.;Umlauf, Anya;Grelotti, David J.;Sones, Emily G.;Mastropietro, Kyle F.;Suhandynata, Raymond T.;Huestis, Marilyn A.;Grant, Igor;Fitzgerald, Robert L.
• 通讯作者: Fitzgerald, Robert L.